Anti-Influenza Virus Activity of Water Soluble Extracts of Sanicula  europaeaL. Rhizomes

Kadir TURAN

Makale detayları

Anti-Influenza Virus Activity of Water Soluble Extracts of Sanicula europaeaL. Rhizomes

Yazarlar:

Kadir TURAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 1999 Vol.23 Issue 3, pp.369-376

Belge Tipi:

Makale

Yayın Tarihi:

2/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000814268

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Anahtar kelimeler:

Özet:

 

The effects of the Sanicula europaea L. rhizome extracts on influenza virus replication in  MDCK cells were investigated. Four different fractions (Fr.I R , Fr.II R , Fr. III R , Fr. IV R ) were obtained  from the crude extract of Sanicula europaea L. rhizomes through Sephadex G-100 gel filtration col-umn  chromatography. Fr.I R , Fr.II R , and Fr. III R , were found to be non-toxic to MDCK cells up to a con-centration  of 100 ?g/ml. However, Fr. IV R was found to be slightly toxic at a concentration of 100  ?g/ml. The antriviral activity of non-toxic fractions (Fr.I R , Fr.II R , and Fr. III R ) against influenza virus-es  was tested by plaque inhibition test. The replication of influenza A/PR/8/34 viruses was inhibited by  these fractions. The highest activity against influenza A/PR/8/34 was found in Fr.II R ..Influenza  A/Vic/1/75 produced microscopic plaques in the presence of the extract. However, the same fractions  were not effective against influenza B/Lee/40. These observations show that the Sanicula rhizome  extract contains an anti-influenza A virus substance.

 

The effects of the Sanicula europaea L. rhizome extracts on influenza virus replication in  MDCK cells were investigated. Four different fractions (Fr.I R , Fr.II R , Fr. III R , Fr. IV R ) were obtained  from the crude extract of Sanicula europaea L. rhizomes through Sephadex G-100 gel filtration col-umn  chromatography. Fr.I R , Fr.II R , and Fr. III R , were found to be non-toxic to MDCK cells up to a con-centration  of 100 ?g/ml. However, Fr. IV R was found to be slightly toxic at a concentration of 100  ?g/ml. The antriviral activity of non-toxic fractions (Fr.I R , Fr.II R , and Fr. III R ) against influenza virus-es  was tested by plaque inhibition test. The replication of influenza A/PR/8/34 viruses was inhibited by  these fractions. The highest activity against influenza A/PR/8/34 was found in Fr.II R ..Influenza  A/Vic/1/75 produced microscopic plaques in the presence of the extract. However, the same fractions  were not effective against influenza B/Lee/40. These observations show that the Sanicula rhizome  extract contains an anti-influenza A virus substance.

Makale detayları

Anti-Influenza Virus Activity of Water Soluble Extracts of Sanicula europaeaL. Rhizomes

Yazarlar:

Kadir TURAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 1999 Vol.23 Issue 3, pp.369-376

Belge Tipi:

Makale

Yayın Tarihi:

2/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000814268

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Sanicula europaea L.

Influenza

Antiviral.

Sayı

Makale detayları

Anti-Influenza Virus Activity of Water Soluble Extracts of Sanicula europaeaL. Rhizomes

Yazarlar: Kadir TURAN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Biology 1999 Vol.23 Issue 3, pp.369-376

Belge Tipi: Makale

Yayın Tarihi: 2/1999

Belge Dili: Türkçe

Document ID (Org No.): 2000814268

Sıklık: İki Aylık

eISSN: 1303-6092

pISSN: 1300-0152

Sanicula europaea L.

Influenza

Antiviral.

Sayı

Yazarlar:

Kadir TURAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 1999 Vol.23 Issue 3, pp.369-376

Belge Tipi:

Makale

Yayın Tarihi:

2/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000814268

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152