Effect of Taurine on Experimental Facial Paralysis and Dry Eye in Rats

Hacı Koç; İbrahim Koçak; Mehmet Tokmak; Saim Kale; Ali Gök; Serif Demir

Makale detayları

Effect of Taurine on Experimental Facial Paralysis and Dry Eye in Rats

Yazarlar:

Hacı Koç | İbrahim Koçak | Mehmet Tokmak | Saim Kale | Ali Gök | Serif Demir

Yayıncı:

Duzce University

Ana Başlıklar:

Ophthalmology

Dergi:

Duzce Medical Journal Vol.27 Issue 2, pp.118-122

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347613

pISSN:

1307-671X

Anahtar kelimeler:

Özet:

 Aim: This study aimed to evaluate dry eye development and the efficacy of taurine for dry eye treatment in a rat model with facial paralysis. Material and Methods: Thirty-two rats were divided into four groups with eight rats in each. The rats in groups 2, 3, and 4 underwent facial paralysis surgically, while the rats in group 1 remained as controls. The rats in group 2 did not receive any treatment. Group 3 was treated with 0.2 sodium hyaluronate, and group 4 was treated with 0.2 sodium hyaluronate and 0.5 taurine. The results of the first and last Schirmers tests were compared. Results: When the Schirmers tests were performed in rats with facial paralysis under general anesthesia to detect dry eye, the scores were low, indicating that general anesthesia increased dry eye in all groups. Thus, Schirmers tests were performed without general anesthesia. The final test results were significantly different between groups p0.001. Pairwise comparisons revealed that there was a significant decrease in groups 2 p0.001 and 3 p0.002 compared to the control group. Group 4 was similar to the control group p0.304 and had a significant improvement compared to group 2 p0.037. No statistically significant difference was found between groups 2 and 4 p0.566. Conclusion: Taurine seems to have the potential to be effective in relieving dry eye symptoms. This could be related to the dominantly antioxidant effect of taurine. These results warrant further studies with larger sample size to determine the effectiveness of taurine for dry eye treatment.

 Aim: This study aimed to evaluate dry eye development and the efficacy of taurine for dry eye treatment in a rat model with facial paralysis. Material and Methods: Thirty-two rats were divided into four groups with eight rats in each. The rats in groups 2, 3, and 4 underwent facial paralysis surgically, while the rats in group 1 remained as controls. The rats in group 2 did not receive any treatment. Group 3 was treated with 0.2 sodium hyaluronate, and group 4 was treated with 0.2 sodium hyaluronate and 0.5 taurine. The results of the first and last Schirmers tests were compared. Results: When the Schirmers tests were performed in rats with facial paralysis under general anesthesia to detect dry eye, the scores were low, indicating that general anesthesia increased dry eye in all groups. Thus, Schirmers tests were performed without general anesthesia. The final test results were significantly different between groups p0.001. Pairwise comparisons revealed that there was a significant decrease in groups 2 p0.001 and 3 p0.002 compared to the control group. Group 4 was similar to the control group p0.304 and had a significant improvement compared to group 2 p0.037. No statistically significant difference was found between groups 2 and 4 p0.566. Conclusion: Taurine seems to have the potential to be effective in relieving dry eye symptoms. This could be related to the dominantly antioxidant effect of taurine. These results warrant further studies with larger sample size to determine the effectiveness of taurine for dry eye treatment.

 Aim: This study aimed to evaluate dry eye development and the efficacy of taurine for dry eye treatment in a rat model with facial paralysis. Material and Methods: Thirty-two rats were divided into four groups with eight rats in each. The rats in groups 2, 3, and 4 underwent facial paralysis surgically, while the rats in group 1 remained as controls. The rats in group 2 did not receive any treatment. Group 3 was treated with 0.2 sodium hyaluronate, and group 4 was treated with 0.2 sodium hyaluronate and 0.5 taurine. The results of the first and last Schirmers tests were compared. Results: When the Schirmers tests were performed in rats with facial paralysis under general anesthesia to detect dry eye, the scores were low, indicating that general anesthesia increased dry eye in all groups. Thus, Schirmers tests were performed without general anesthesia. The final test results were significantly different between groups p0.001. Pairwise comparisons revealed that there was a significant decrease in groups 2 p0.001 and 3 p0.002 compared to the control group. Group 4 was similar to the control group p0.304 and had a significant improvement compared to group 2 p0.037. No statistically significant difference was found between groups 2 and 4 p0.566. Conclusion: Taurine seems to have the potential to be effective in relieving dry eye symptoms. This could be related to the dominantly antioxidant effect of taurine. These results warrant further studies with larger sample size to determine the effectiveness of taurine for dry eye treatment.

 Amaç: Bu çalışmanın amacı fasiyal paralizili sıçan modelinde kuru göz gelişimini ve kuru göz tedavisinde taurinin etkinliğini değerlendirmektir. Gereç ve Yöntemler: Otuz iki sıçan her birinde sekiz sıçan olacak şekilde dört gruba ayrıldı. Grup 2, 3 ve 4teki sıçanlara cerrahi olarak fasiyal paralizi uygulanırken, grup 1deki sıçanlar kontrol grubu olarak bırakıldı. Grup 2deki sıçanlara herhangi bir tedavi uygulanmadı. Grup 3 0,2lik sodyum hiyaluronat ile tedavi edildi ve grup 4 ise 0,2lik sodyum hiyaluronat ve 0,5lik taurin ile tedavi edildi. İlk ve son Schirmer testinin sonuçları karşılaştırıldı. Bulgular: Fasiyal paralizi olan sıçanlarda kuru göz hastalığını tespit etmek amacıyla genel anestezi altında Schirmer testleri yapıldığında skorların düşük çıkması, genel anestezinin tüm gruplarda kuru gözü arttırdığını gösterdi. Bu nedenle Schirmer testleri genel anestezi olmadan gerçekleştirildi. Son test sonuçları gruplar arasında önemli ölçüde farklıydı p0.001. İkili karşılaştırmalar grup 2de p0,001 ve 3te p0,002 kontrol grubuna kıyasla anlamlı bir azalma olduğunu gösterdi. Grup 4 ise kontrol grubuna benzerlik göstermekteydi p0,304 ve grup 2 ile karşılaştırıldığında belirgin bir düzelme vardı p0,037. Grup 2 ile 4 arasında ise istatistiksel olarak anlamlı bir fark bulunmadı p0,566. Sonuç: Taurinin kuru göz semptomlarını hafifletmede etkili olma potansiyeli olduğu görünmektedir. Bu, taurinin baskın antioksidan etkisi ile ilişkili olabilir. Bu sonuçlar, taurinin kuru göz tedavisindeki etkinliğini belirlemek için daha büyük bir örneklemde daha fazla çalışmayı gerektirmektedir.

Makale detayları

Effect of Taurine on Experimental Facial Paralysis and Dry Eye in Rats

Yazarlar:

Hacı Koç | İbrahim Koçak | Mehmet Tokmak | Saim Kale | Ali Gök | Serif Demir

Yayıncı:

Duzce University

Ana Başlıklar:

Ophthalmology

Dergi:

Duzce Medical Journal Vol.27 Issue 2, pp.118-122

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347613

pISSN:

1307-671X

Dry eye

facial paralysis

Schirmer’s test

taurineKuru göz

fasyal paralizi

Schirmer testi

taurine

Sayı

Makale detayları

Yazarlar: Hacı Koç | İbrahim Koçak | Mehmet Tokmak | Saim Kale | Ali Gök | Serif Demir

Yayıncı: Duzce University

Ana Başlıklar: Ophthalmology

Dergi: Duzce Medical Journal Vol.27 Issue 2, pp.118-122

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347613

pISSN: 1307-671X

Sayı

Yazarlar:

Hacı Koç | İbrahim Koçak | Mehmet Tokmak | Saim Kale | Ali Gök | Serif Demir

Yayıncı:

Duzce University

Ana Başlıklar:

Ophthalmology

Dergi:

Duzce Medical Journal Vol.27 Issue 2, pp.118-122

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347613

pISSN:

1307-671X