Investigation of the Effect of Liver Supportive Feed Additives on Metabolic Profile Tests and Colostrum Dry Matter of Dairy Cows in Dry Period

Gencay Ekinci; Veli Özbek

Makale detayları

Investigation of the Effect of Liver Supportive Feed Additives on Metabolic Profile Tests and Colostrum Dry Matter of Dairy Cows in Dry Period

Yazarlar:

Gencay Ekinci | Veli Özbek

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Veteriner İç Hastalıkları

Dergi:

Van Veterinary Journal Vol.36 Issue 2, pp.71-79

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001355481

pISSN:

2149-3359

Anahtar kelimeler:

Özet:

 This study aimed to investigate the effects of a liver-supportive feed additive LSFA on metabolic profile parameters and colostrum dry matter DM content in dairy cows during the dry period. A total of 34 clinically healthy cows 18 Holstein and 16 Simmental, aged between 3 and 5 years, were randomly assigned to two groups at the onset of the dry period: the study group SG; n17 and the control group CG; n17. While the CG received only the standard dry period ration, the SG was additionally supplemented with 100 gcowday of LSFA for 15 consecutive days. Blood samples were collected on day 0 and day 35 of the dry period to assess macro-mineral levels and selected metabolic profile parameters. Colostrum samples were obtained within two hours postpartum, and DM content was measured using an optical Brix refractometer. On day 35, the mean blood urea nitrogen BUN level in the SG was significantly lower compared to day 0 p0.007, whereas the mean aspartate aminotransferase AST activity was significantly higher p0.001. Additionally, the average colostrum DM content in the SG Brix26.671.14 was significantly greater than that in the CG Brix25.800.83 p0.029. These results indicate that LSFA supplementation may influence liver-related nitrogen metabolism, as evidenced by decreased BUN levels and increased AST activity-an enzyme commonly associated with hepatic cellular damage. Although these findings suggest a potential impact of LSFA on liver function, definitive conclusions cannot be drawn without more comprehensive evaluations involving an extended biochemical panel. Future studies incorporating liver function enzymes, protein fractions, and antioxidant parameters are warranted to better elucidate the physiological effects of such feed additives.

 This study aimed to investigate the effects of a liver-supportive feed additive LSFA on metabolic profile parameters and colostrum dry matter DM content in dairy cows during the dry period. A total of 34 clinically healthy cows 18 Holstein and 16 Simmental, aged between 3 and 5 years, were randomly assigned to two groups at the onset of the dry period: the study group SG; n17 and the control group CG; n17. While the CG received only the standard dry period ration, the SG was additionally supplemented with 100 gcowday of LSFA for 15 consecutive days. Blood samples were collected on day 0 and day 35 of the dry period to assess macro-mineral levels and selected metabolic profile parameters. Colostrum samples were obtained within two hours postpartum, and DM content was measured using an optical Brix refractometer. On day 35, the mean blood urea nitrogen BUN level in the SG was significantly lower compared to day 0 p0.007, whereas the mean aspartate aminotransferase AST activity was significantly higher p0.001. Additionally, the average colostrum DM content in the SG Brix26.671.14 was significantly greater than that in the CG Brix25.800.83 p0.029. These results indicate that LSFA supplementation may influence liver-related nitrogen metabolism, as evidenced by decreased BUN levels and increased AST activity-an enzyme commonly associated with hepatic cellular damage. Although these findings suggest a potential impact of LSFA on liver function, definitive conclusions cannot be drawn without more comprehensive evaluations involving an extended biochemical panel. Future studies incorporating liver function enzymes, protein fractions, and antioxidant parameters are warranted to better elucidate the physiological effects of such feed additives.

 This study aimed to investigate the effects of a liver-supportive feed additive LSFA on metabolic profile parameters and colostrum dry matter DM content in dairy cows during the dry period. A total of 34 clinically healthy cows 18 Holstein and 16 Simmental, aged between 3 and 5 years, were randomly assigned to two groups at the onset of the dry period: the study group SG; n17 and the control group CG; n17. While the CG received only the standard dry period ration, the SG was additionally supplemented with 100 gcowday of LSFA for 15 consecutive days. Blood samples were collected on day 0 and day 35 of the dry period to assess macro-mineral levels and selected metabolic profile parameters. Colostrum samples were obtained within two hours postpartum, and DM content was measured using an optical Brix refractometer. On day 35, the mean blood urea nitrogen BUN level in the SG was significantly lower compared to day 0 p0.007, whereas the mean aspartate aminotransferase AST activity was significantly higher p0.001. Additionally, the average colostrum DM content in the SG Brix26.671.14 was significantly greater than that in the CG Brix25.800.83 p0.029. These results indicate that LSFA supplementation may influence liver-related nitrogen metabolism, as evidenced by decreased BUN levels and increased AST activity-an enzyme commonly associated with hepatic cellular damage. Although these findings suggest a potential impact of LSFA on liver function, definitive conclusions cannot be drawn without more comprehensive evaluations involving an extended biochemical panel. Future studies incorporating liver function enzymes, protein fractions, and antioxidant parameters are warranted to better elucidate the physiological effects of such feed additives.

 Bu çalışmanın amacı, kuru dönem süt sığırlarında karaciğer destekleyici bir yem katkı maddesinin KDYK metabolik profil parametreleri ve kolostrum kuru madde KM düzeyi üzerine etkilerini araştırmaktır. Çalışmaya 3-5 yaş aralığında, klinik olarak sağlıklı toplam 34 inek 18 Holstein, 16 Simmental dâhil edilmiştir. Kuru dönemin başında rastgele olarak iki gruba ayrılan hayvanlardan 17si çalışma grubunu ÇG, 17si ise kontrol grubunu KG oluşturmuştur. Kontrol grubundaki ineklere yalnızca kuru dönem rasyonu uygulanırken, çalışma grubundaki ineklere bu rasyona ek olarak 15 gün boyunca günlük 100 ginek KDYK verilmiştir. Kuru dönemin 0. ve 35. günlerinde alınan kan örneklerinden makro mineraller ve bazı metabolik profil parametreleri analiz edilmiştir. Kolostrum örnekleri doğumdan sonraki ilk iki saat içinde toplanmış ve kuru madde düzeyi optik Brix refraktometresi ile ölçülmüştür. Çalışma grubundaki ineklerin 35. gün ortalama serum BUN düzeyi, 0. güne göre istatistiksel olarak anlamlı şekilde düşük bulunmuştur p0.007. Buna karşılık, aynı grubun ortalama AST düzeyi 35. günde, 0. güne kıyasla anlamlı şekilde yüksek tespit edilmiştir p0.001. Ayrıca, çalışma grubundaki ineklerden elde edilen kolostrumun ortalama KM oranı Brix26.671.14, kontrol grubuna göre Brix25.800.83 anlamlı düzeyde daha yüksek bulunmuştur p0.029. Elde edilen bulgular, KDYK kullanımının karaciğerde azot metabolizmasını etkileyebileceğini ve karaciğer hücre hasarının biyokimyasal göstergelerinden biri olan AST enzimi aktivitesinde artışa yol açabileceğini göstermektedir. Bununla birlikte, bu etkinin karaciğer fonksiyonları üzerindeki kesin yansımaları, daha kapsamlı ve doğrudan karaciğer değerlendirmeleri yapılmadan net olarak belirlenemez. Bu nedenle, karaciğer fonksiyon enzimleri, protein fraksiyonları ve antioksidan parametreleri gibi daha geniş bir biyokimyasal paneli içeren kontrollü çalışmalara ihtiyaç vardır.

Makale detayları

Investigation of the Effect of Liver Supportive Feed Additives on Metabolic Profile Tests and Colostrum Dry Matter of Dairy Cows in Dry Period

Yazarlar:

Gencay Ekinci | Veli Özbek

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Veteriner İç Hastalıkları

Dergi:

Van Veterinary Journal Vol.36 Issue 2, pp.71-79

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001355481

pISSN:

2149-3359

Cattle

Colostrum

Metabolic profile tests

Minerals

Peripartum periodKolostrum

Metabolik profil testleri

Mineraller

Peripartum dönem

Sığır

Sayı

Makale detayları

Yazarlar: Gencay Ekinci | Veli Özbek

Yayıncı: Van Yuzuncu Yıl University

Ana Başlıklar: Veteriner İç Hastalıkları

Dergi: Van Veterinary Journal Vol.36 Issue 2, pp.71-79

Belge Tipi: Makale

Yayın Tarihi: 7/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001355481

pISSN: 2149-3359

Sayı

Yazarlar:

Gencay Ekinci | Veli Özbek

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Veteriner İç Hastalıkları

Dergi:

Van Veterinary Journal Vol.36 Issue 2, pp.71-79

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001355481

pISSN:

2149-3359