Evaluation of clinical and laboratory features of cases with infant anaphylaxis

Aylin Kont Özhan; Aysu İlhan Yalaki; Veysi Akbey; Nazan Tökmeci; Ali Demirhan; Tuğba Arıkoğlu; Semanur Kuyucu

Makale detayları

Evaluation of clinical and laboratory features of cases with infant anaphylaxis

Yazarlar:

Aylin Kont Özhan | Aysu İlhan Yalaki | Veysi Akbey | Nazan Tökmeci | Ali Demirhan | Tuğba Arıkoğlu | Semanur Kuyucu

Yayıncı:

Mersin University

Ana Başlıklar:

Cerrahi (Diğer)

Dergi:

Mersin Üniversitesi Sağlık Bilimleri Dergisi Vol.16 Issue 3, pp.483-494

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001304721

pISSN:

1308-0830

Anahtar kelimeler:

Özet:

 Aim: The incidence of infant anaphylaxis has been increasing. The diagnosis of anaphylaxis in this age group is very difficult and there is limited data in the literature. In our study, we aimed to determine the etiology, clinical and laboratory features of anaphylaxis cases observed in the infantile age group. Method: The records of 16 children under two years of age who were followed with the diagnosis of infant anaphylaxis in the Pediatric Immunology and Allergy Clinic of Mersin University Faculty of Medicine between January 2020 and January 2023 were evaluated retrospectively. Results: A total of 16 infant anaphylaxis patients; 10 62.5 boys and six 37.5 girls, were included in the study. The mean age at the onset of anaphylaxis was 5.683.75 months. Food was identified as the trigger in 14 patients 87.5 and drugs in two cases 12.5. Milk n8, 50 was the most common causative agent. Five 31.2 of our patients had atopic dermatitis and three 18.7 had episodic wheezing. Skin andor mucous membrane involvement were the most common ivolvement n15, 93.7, followed by respiratory system involvement n12, 75. The most common clinical finding was urticaria with a rate of 68.7, and wheezing 62.5 and dyspnea 62.5 were other common findings. All patients with a history of food anaphylaxis had positive skin prick test andor specific immunglobulin-E with the responsible food. Adrenaline was administered intramuscularly in seven patients 43.7. Seven patients 43.7 were prescribed adrenaline auto-injectors as prophylaxis after anaphylaxis. Conclusion: In our study, it was found that the most common triggering agents were cows milk and egg. The most commonly involved system was the skin, but cardiovascular and neurologic involvement were also possible. Adrenaline administration as the first-line treatment and adrenaline auto-injector prescription rate were low, and the use of auto-injectors by parents was low. There is a need to raise awareness and educate healthcare professionals, parents and caregivers about infant anaphylaxis.

 Aim: The incidence of infant anaphylaxis has been increasing. The diagnosis of anaphylaxis in this age group is very difficult and there is limited data in the literature. In our study, we aimed to determine the etiology, clinical and laboratory features of anaphylaxis cases observed in the infantile age group. Method: The records of 16 children under two years of age who were followed with the diagnosis of infant anaphylaxis in the Pediatric Immunology and Allergy Clinic of Mersin University Faculty of Medicine between January 2020 and January 2023 were evaluated retrospectively. Results: A total of 16 infant anaphylaxis patients; 10 62.5 boys and six 37.5 girls, were included in the study. The mean age at the onset of anaphylaxis was 5.683.75 months. Food was identified as the trigger in 14 patients 87.5 and drugs in two cases 12.5. Milk n8, 50 was the most common causative agent. Five 31.2 of our patients had atopic dermatitis and three 18.7 had episodic wheezing. Skin andor mucous membrane involvement were the most common ivolvement n15, 93.7, followed by respiratory system involvement n12, 75. The most common clinical finding was urticaria with a rate of 68.7, and wheezing 62.5 and dyspnea 62.5 were other common findings. All patients with a history of food anaphylaxis had positive skin prick test andor specific immunglobulin-E with the responsible food. Adrenaline was administered intramuscularly in seven patients 43.7. Seven patients 43.7 were prescribed adrenaline auto-injectors as prophylaxis after anaphylaxis. Conclusion: In our study, it was found that the most common triggering agents were cows milk and egg. The most commonly involved system was the skin, but cardiovascular and neurologic involvement were also possible. Adrenaline administration as the first-line treatment and adrenaline auto-injector prescription rate were low, and the use of auto-injectors by parents was low. There is a need to raise awareness and educate healthcare professionals, parents and caregivers about infant anaphylaxis.

 Aim: The incidence of infant anaphylaxis has been increasing. The diagnosis of anaphylaxis in this age group is very difficult and there is limited data in the literature. In our study, we aimed to determine the etiology, clinical and laboratory features of anaphylaxis cases observed in the infantile age group. Method: The records of 16 children under two years of age who were followed with the diagnosis of infant anaphylaxis in the Pediatric Immunology and Allergy Clinic of Mersin University Faculty of Medicine between January 2020 and January 2023 were evaluated retrospectively. Results: A total of 16 infant anaphylaxis patients; 10 62.5 boys and six 37.5 girls, were included in the study. The mean age at the onset of anaphylaxis was 5.683.75 months. Food was identified as the trigger in 14 patients 87.5 and drugs in two cases 12.5. Milk n8, 50 was the most common causative agent. Five 31.2 of our patients had atopic dermatitis and three 18.7 had episodic wheezing. Skin andor mucous membrane involvement were the most common ivolvement n15, 93.7, followed by respiratory system involvement n12, 75. The most common clinical finding was urticaria with a rate of 68.7, and wheezing 62.5 and dyspnea 62.5 were other common findings. All patients with a history of food anaphylaxis had positive skin prick test andor specific immunglobulin-E with the responsible food. Adrenaline was administered intramuscularly in seven patients 43.7. Seven patients 43.7 were prescribed adrenaline auto-injectors as prophylaxis after anaphylaxis. Conclusion: In our study, it was found that the most common triggering agents were cows milk and egg. The most commonly involved system was the skin, but cardiovascular and neurologic involvement were also possible. Adrenaline administration as the first-line treatment and adrenaline auto-injector prescription rate were low, and the use of auto-injectors by parents was low. There is a need to raise awareness and educate healthcare professionals, parents and caregivers about infant anaphylaxis.

 Amaç: İnfant anafilaksi insidansı giderek artmaktadır. Bu yaş grubunda anafilaksi tanısının konulması oldukça zordur ve literatürde bu konu ile ilgili veriler kısıtlıdır. Çalışmamızda infantil yaş grubunda gözlenen anafilaksi olgularının etiyolojileri, klinik ve laboratuvar özelliklerinin belirlenmesi amaçlanmıştır. Yöntem: Mersin Üniversitesi Tıp Fakültesi Çocuk İmmünoloji ve Alerji Kliniğinde Ocak 2020-Ocak 2023 tarihleri arasında infant anafilaksisi tanısıyla izlenen iki yaş altı 16 çocuğun dosyaları retrospektif olarak değerlendirildi. Bulgular: Çalışmaya 10 62.5 erkek, altı 37.5 kız olmak üzere toplam 16 infant anafilaksi hastası dahil edildi. Anafilaksi geçirme yaşı ortalama 5.683.75 aydı. Hastaların 14ünde 87.5 tetikleyici olarak besin, iki olguda ise ilaç 12.5 olarak belirlendi. Besinlerden ise en sık süt n8, 50 nedensel ajan olarak belirlendi. Hastalarımızın beşinde 31.2 atopik dermatit, üçünde 18.7 epizodik hışıltı eşlik etmekteydi. Hastalarımızda en sık deri veveya mukoza tutulumu görülürken n15, 93.7, bunu solunum sistemi tutulumu takip etti n12, 75. En sık görülen klinik bulgu 68.7 oranında ürtiker olup, hışıltı 62.5 ve solunum sıkıntısı 62.5 diğer sık görülen bulgulardı. Besin anafilaksisi öyküsü olan hastaların tamamında sorumlu besin ile yapılan deri prik testi veveya spesifik immünglobulin E pozitifti. Tedavi olarak yedi hastaya 43.7 adrenalin intramuskuler uygulandı. Profilaksi olarak yedi hastaya 43.7 anafilaksi sonrası adrenalin oto-enjektör reçete edildiği görüldü. Sonuç: Çalışmamızda en yaygın tetikleyici ajanın inek sütü ve yumurta, en sık tutulan sistemin deri olduğu ancak kardiyovasküler ve nörolojik tutulumunda olabileceği, ilk tedavi olarak adrenalin uygulamasının ve adrenalin oto-enjektör reçeteleme oranlarının düşük olduğu, ebeveynlerde oto-enjektör kullanımının az olduğu saptanmıştır. İnfant anafilaksisi konusunda sağlık çalışanlarının, ebeveynlerin ve diğer bakım verenlerin bilinçlendirilmesi ve eğitilmesi gerekmektedir.

Makale detayları

Evaluation of clinical and laboratory features of cases with infant anaphylaxis

Yazarlar:

Aylin Kont Özhan | Aysu İlhan Yalaki | Veysi Akbey | Nazan Tökmeci | Ali Demirhan | Tuğba Arıkoğlu | Semanur Kuyucu

Yayıncı:

Mersin University

Ana Başlıklar:

Cerrahi (Diğer)

Dergi:

Mersin Üniversitesi Sağlık Bilimleri Dergisi Vol.16 Issue 3, pp.483-494

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001304721

pISSN:

1308-0830

Infant

anaphylaxis

adrenalineİnfant

anafilaksi

adrenalin

Sayı

Makale detayları

Evaluation of clinical and laboratory features of cases with infant anaphylaxis

Yazarlar: Aylin Kont Özhan | Aysu İlhan Yalaki | Veysi Akbey | Nazan Tökmeci | Ali Demirhan | Tuğba Arıkoğlu | Semanur Kuyucu

Yayıncı: Mersin University

Ana Başlıklar: Cerrahi (Diğer)

Dergi: Mersin Üniversitesi Sağlık Bilimleri Dergisi Vol.16 Issue 3, pp.483-494

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001304721

pISSN: 1308-0830

Infant

anaphylaxis

adrenalineİnfant

anafilaksi

adrenalin

Sayı

Yazarlar:

Aylin Kont Özhan | Aysu İlhan Yalaki | Veysi Akbey | Nazan Tökmeci | Ali Demirhan | Tuğba Arıkoğlu | Semanur Kuyucu

Yayıncı:

Mersin University

Ana Başlıklar:

Cerrahi (Diğer)

Dergi:

Mersin Üniversitesi Sağlık Bilimleri Dergisi Vol.16 Issue 3, pp.483-494

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001304721

pISSN:

1308-0830