Frequency of asymptomatic hyperuricemia in advanced-stage symptomatic knee osteoarthritis and its relationship with inflammatory parameters

Reyhan Köse Çobanoğlu; Bilal Bedirhan Akbaş; Vahit Yıldız

Makale detayları

Frequency of asymptomatic hyperuricemia in advanced-stage symptomatic knee osteoarthritis and its relationship with inflammatory parameters

Yazarlar:

Reyhan Köse Çobanoğlu | Bilal Bedirhan Akbaş | Vahit Yıldız

Yayıncı:

Pamukkale University

Ana Başlıklar:

Romatoloji ve Artrit

Dergi:

Pamukkale Tıp Dergisi Vol.17 Issue 3, pp.412-418

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314149

pISSN:

1308-0865

Anahtar kelimeler:

Özet:

 Purpose: Hyperuricemia HU is thought to be a risk factor in the development and progression of knee osteoarthritis OA. We sought the frequency of asymptomatic HU in advanced knee OA patients and whether it was related to systemic inflammation. Materials and methods: This is a single-center, retrospective study including patients with symptomatic stage 34 knee OA classified based on Kellgren-Lawrence K-L system. Demographic data and serum uric acid UA, hemogram parameters, erythrocyte sedimentation rate ESR, C-reactive protein CRP, body mass index BMI were recorded. Neutrophillymphocyte ratio NLR, plateletlymphocyte ratio PLR and systemic immune-inflammation index SIIneutrophil count  platelet countlymphocyte count were calculated. Patients withwithout hyperuricemia were defined as Group 1 and Group 2, respectively. Demographic and laboratory data were compared between the groups. Results: Hyperuricemia was present in 51 of 240 patients 21. There was no significant difference between the groups based on age Group1: 70.547.02, Group2: 68.636.29, p0.07 and BMI Group 1: 34 kgm2 27.7-41, Group2: 32 kgm2 25-51.5, p0.107. NLR, PLR, and SII were similar between two groups p0.404, p0.604, p0.537. While there was no difference in ESR values between the two groups p0.051, CRP levels were found to be significantly higher in Group 1 p0.007. A positive correlation was detected between serum UA level and CRP rho0.243, p0.001, SII rho0.173, p0.017, NLR rho0.154, p0.035 and PLR rho0.166, p0.023 in Group 2. No correlation was detected between serum UA level and ESR, CRP, SII, NLR, PLR and BMI in Group 1. Conclusion: Asymptomatic HU was found 1 in 5 of advanced-stage knee OA patients and may contribute to inflammation in knee OA. Serum UA level may need to be reduced to normal level in these patients.

 Purpose: Hyperuricemia HU is thought to be a risk factor in the development and progression of knee osteoarthritis OA. We sought the frequency of asymptomatic HU in advanced knee OA patients and whether it was related to systemic inflammation. Materials and methods: This is a single-center, retrospective study including patients with symptomatic stage 34 knee OA classified based on Kellgren-Lawrence K-L system. Demographic data and serum uric acid UA, hemogram parameters, erythrocyte sedimentation rate ESR, C-reactive protein CRP, body mass index BMI were recorded. Neutrophillymphocyte ratio NLR, plateletlymphocyte ratio PLR and systemic immune-inflammation index SIIneutrophil count  platelet countlymphocyte count were calculated. Patients withwithout hyperuricemia were defined as Group 1 and Group 2, respectively. Demographic and laboratory data were compared between the groups. Results: Hyperuricemia was present in 51 of 240 patients 21. There was no significant difference between the groups based on age Group1: 70.547.02, Group2: 68.636.29, p0.07 and BMI Group 1: 34 kgm2 27.7-41, Group2: 32 kgm2 25-51.5, p0.107. NLR, PLR, and SII were similar between two groups p0.404, p0.604, p0.537. While there was no difference in ESR values between the two groups p0.051, CRP levels were found to be significantly higher in Group 1 p0.007. A positive correlation was detected between serum UA level and CRP rho0.243, p0.001, SII rho0.173, p0.017, NLR rho0.154, p0.035 and PLR rho0.166, p0.023 in Group 2. No correlation was detected between serum UA level and ESR, CRP, SII, NLR, PLR and BMI in Group 1. Conclusion: Asymptomatic HU was found 1 in 5 of advanced-stage knee OA patients and may contribute to inflammation in knee OA. Serum UA level may need to be reduced to normal level in these patients.

 Purpose: Hyperuricemia HU is thought to be a risk factor in the development and progression of knee osteoarthritis OA. We sought the frequency of asymptomatic HU in advanced knee OA patients and whether it was related to systemic inflammation. Materials and methods: This is a single-center, retrospective study including patients with symptomatic stage 34 knee OA classified based on Kellgren-Lawrence K-L system. Demographic data and serum uric acid UA, hemogram parameters, erythrocyte sedimentation rate ESR, C-reactive protein CRP, body mass index BMI were recorded. Neutrophillymphocyte ratio NLR, plateletlymphocyte ratio PLR and systemic immune-inflammation index SIIneutrophil count  platelet countlymphocyte count were calculated. Patients withwithout hyperuricemia were defined as Group 1 and Group 2, respectively. Demographic and laboratory data were compared between the groups. Results: Hyperuricemia was present in 51 of 240 patients 21. There was no significant difference between the groups based on age Group1: 70.547.02, Group2: 68.636.29, p0.07 and BMI Group 1: 34 kgm2 27.7-41, Group2: 32 kgm2 25-51.5, p0.107. NLR, PLR, and SII were similar between two groups p0.404, p0.604, p0.537. While there was no difference in ESR values between the two groups p0.051, CRP levels were found to be significantly higher in Group 1 p0.007. A positive correlation was detected between serum UA level and CRP rho0.243, p0.001, SII rho0.173, p0.017, NLR rho0.154, p0.035 and PLR rho0.166, p0.023 in Group 2. No correlation was detected between serum UA level and ESR, CRP, SII, NLR, PLR and BMI in Group 1. Conclusion: Asymptomatic HU was found 1 in 5 of advanced-stage knee OA patients and may contribute to inflammation in knee OA. Serum UA level may need to be reduced to normal level in these patients.

 Amaç: Hiperüriseminin diz OA gelişmesinde ve ilerlemesinde risk faktörü olduğu düşünülmektedir. Çalışmamızda ileri evre diz OA hastalarında asemptomatik hiperürisemi sıklığı ve sistemik inflamasyonla ilişkili olup olmadığının araştırılması amaçlandı. Gereç ve yöntem: Semptomatik diz OA olan ve radyografik Kellgren-Lawrence K-L sistemine göre derece 3 veya 4 olarak sınıflandırılan hastaları dahil eden tek merkezli, retrospektif bir çalışmadır. Yaş, cinsiyet, komorbiditeler, kullanılan ilaçlar, serum ürik asit ÜA, hemogram parametreleri, eritrosit sedimantasyon hızı ESH, C-reaktif protein CRP ve vücut kitle indeksi VKİ kaydedildi. Nötrofillenfosit oranı NLO, trombositlenfosit oranı TLO ve sistemik immün-inflamasyon indeksi Sİİnötrofil sayısı  trombosit sayısılenfosit sayısı hesaplandı. Hiperürisemisi olan ve olmayan hastalar sırasıyla Grup 1 ve Grup 2 olarak tanımlandı ve gruplar arasında demografik ve laboratuvar veriler karşılaştırıldı. Bulgular: 240 hastanın 51 inde hiperürisemi mevcuttu 21. Grup 1de yaş ortalaması 70.547.02, BKİ 34 kgm2 27.7-41, grup 2 de yaş ortalaması 68.636.29, BKİ 32 kgm2 25- 51.5, gruplar arasında anlamlı fark yoktu. Grup 1 ve Grup 2 arasında NLO, TLO, Sİİ arasında fark yoktu p0.404, p0.604, p0.537. Her iki grup arasında ESH değerlerinde fark yokken p0.051, CRP düzeyleri grup 1de anlamlı yüksek saptandı p0.007. Grup 2 de ÜA düzeyi ile CRP rho0.243, p0.001, Sİİ rho0.173, p0.017, NLO rho0.154, p0.035 ve PLO rho0.166, p0.023 pozitif ilişki tespit edildi. Ancak Grup 1 de ÜA düzeyi ile ESH, CRP, Sİİ, NLO, PLO ve VKİ arasında ilişki yoktu. Sonuç: Çalışmamızda ileri evre diz OA hastalarının yaklaşık 5de 1inin asemptomatik hiperürisemisinin olduğu gözlendi. Asemptomatik HÜ, diz OA da inflamasyona neden olabilir, sonuç olarak bu hastalarda serum ÜA seviyesinin normale çekilmesi gerekebilir.

Makale detayları

Frequency of asymptomatic hyperuricemia in advanced-stage symptomatic knee osteoarthritis and its relationship with inflammatory parameters

Yazarlar:

Reyhan Köse Çobanoğlu | Bilal Bedirhan Akbaş | Vahit Yıldız

Yayıncı:

Pamukkale University

Ana Başlıklar:

Romatoloji ve Artrit

Dergi:

Pamukkale Tıp Dergisi Vol.17 Issue 3, pp.412-418

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314149

pISSN:

1308-0865

Asymptomatic hyperuricemia

hyperuricemia

knee osteoarthritis

systemic inflammationAsemptomatik hiperürisemi

hiperürisemi

diz osteoartriti

sistemik inflamasyon

Sayı

Makale detayları

Yazarlar: Reyhan Köse Çobanoğlu | Bilal Bedirhan Akbaş | Vahit Yıldız

Yayıncı: Pamukkale University

Ana Başlıklar: Romatoloji ve Artrit

Dergi: Pamukkale Tıp Dergisi Vol.17 Issue 3, pp.412-418

Belge Tipi: Makale

Yayın Tarihi: 5/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001314149

pISSN: 1308-0865

Sayı

Yazarlar:

Reyhan Köse Çobanoğlu | Bilal Bedirhan Akbaş | Vahit Yıldız

Yayıncı:

Pamukkale University

Ana Başlıklar:

Romatoloji ve Artrit

Dergi:

Pamukkale Tıp Dergisi Vol.17 Issue 3, pp.412-418

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314149

pISSN:

1308-0865