Proton Transfer Salt and Metal Complexes of 4,4'-Ethylenedipyridine and 2,3-Pyrazinedicarboxylic Acid: Synthesis, Structural Characterization and Biological Activity

Nurgün Büyükkıdan; Seher Kaya; Halil İlkimen; Aysel Gülbandılar

Makale detayları

Proton Transfer Salt and Metal Complexes of 4,4'-Ethylenedipyridine and 2,3-Pyrazinedicarboxylic Acid: Synthesis, Structural Characterization and Biological Activity

Yazarlar:

Nurgün Büyükkıdan | Seher Kaya | Halil İlkimen | Aysel Gülbandılar

Yayıncı:

Bayburt University

Ana Başlıklar:

Kimya Mühendisliği (Diğer)

Dergi:

Bayburt Üniversitesi Fen Bilimleri Dergisi Vol.7 Issue 2, pp.103-113

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001337020

pISSN:

2667-579X

Anahtar kelimeler:

Özet:

 In this study, a new salt H2BPEPDA, 1 synthesized from 4,4-ethylenedipyridine BPE with 2,3 pyrazinedicarboxylic acid H2PDA and its complexes FeIII H2BPEFe2PDAH2O4n, 2 and NiII NiPDABPE2H2O2n.H2O, 3, were synthesized and defined by using 1H and 13C NMR, TG-DTA, IR, UV Vis, elemental analysis, magnetic susceptibility techniques. In addition, antibacterial and antifungal activities of starting materials and synthesized compounds against Candida albicans yeast and Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli and Listeria monocytogenes bacteria were investigated using the microdilution method and compared with existing antibiotics Cefepime, Vancomycin, Levofloxacin and Fluconazole. Compounds 1-3 were observed to have activity against yeast and bacteria. In particular, compound 3 7.80 µgmL against E. faecalis, compounds 3 7.80 µgmL against B. subtilis bacteria, and compound 1 15.60 µgmL against C. albicans yeast. showed better activity than control compounds.

 In this study, a new salt H2BPEPDA, 1 synthesized from 4,4-ethylenedipyridine BPE with 2,3 pyrazinedicarboxylic acid H2PDA and its complexes FeIII H2BPEFe2PDAH2O4n, 2 and NiII NiPDABPE2H2O2n.H2O, 3, were synthesized and defined by using 1H and 13C NMR, TG-DTA, IR, UV Vis, elemental analysis, magnetic susceptibility techniques. In addition, antibacterial and antifungal activities of starting materials and synthesized compounds against Candida albicans yeast and Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli and Listeria monocytogenes bacteria were investigated using the microdilution method and compared with existing antibiotics Cefepime, Vancomycin, Levofloxacin and Fluconazole. Compounds 1-3 were observed to have activity against yeast and bacteria. In particular, compound 3 7.80 µgmL against E. faecalis, compounds 3 7.80 µgmL against B. subtilis bacteria, and compound 1 15.60 µgmL against C. albicans yeast. showed better activity than control compounds.

 In this study, a new salt H2BPEPDA, 1 synthesized from 4,4-ethylenedipyridine BPE with 2,3 pyrazinedicarboxylic acid H2PDA and its complexes FeIII H2BPEFe2PDAH2O4n, 2 and NiII NiPDABPE2H2O2n.H2O, 3, were synthesized and defined by using 1H and 13C NMR, TG-DTA, IR, UV Vis, elemental analysis, magnetic susceptibility techniques. In addition, antibacterial and antifungal activities of starting materials and synthesized compounds against Candida albicans yeast and Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli and Listeria monocytogenes bacteria were investigated using the microdilution method and compared with existing antibiotics Cefepime, Vancomycin, Levofloxacin and Fluconazole. Compounds 1-3 were observed to have activity against yeast and bacteria. In particular, compound 3 7.80 µgmL against E. faecalis, compounds 3 7.80 µgmL against B. subtilis bacteria, and compound 1 15.60 µgmL against C. albicans yeast. showed better activity than control compounds.

 Bu çalışmada, 4,4-etilendipiridin BPE ile 2,3-pirazindikarboksilik asitin H2PDA yeni bir tuz H2BPEPDA, 1 ve tuzun FeIII H2BPEFe2PDAH2O4n, 2 ve NiII NiPDABPE2H2O2n.H2O, 3 kompleksleri sentezlendi ve 1H ve 13C NMR TG-DTA, IR, UV-Vis, element analizi, manyetik duyarlılık teknikleri kullanılarak önerildi. Ayrıca başlangıç materyallerinin ve sentezlenen bileşiklerin Candida albicans mayası ve Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli ve Listeria monocytogenes bakterilerine karşı antibakteriyel ve antifungal aktiviteleri mikrodilüsyon yöntemi kullanılarak araştırılmış ve mevcut antibiyotiklerle Cefepime, Vankomisin, Levofloksasin ve Flukonazol kıyaslanmıştır. 1-3 Bileşiklerin maya ve bakterilere karşı aktiviteye sahip olduğu gözlendi. Özellikle, E. faecalise karşı bileşik 3 7,80 µgmL, B. subtilis bakterisine karşı bileşik 3 7,80 µgmL ve C. albicans mayasına karşı bileşik 1 15,60 µgmL. kontrol bileşiklerinden daha iyi aktivite gösterdi.

Makale detayları

Proton Transfer Salt and Metal Complexes of 4,4'-Ethylenedipyridine and 2,3-Pyrazinedicarboxylic Acid: Synthesis, Structural Characterization and Biological Activity

Yazarlar:

Nurgün Büyükkıdan | Seher Kaya | Halil İlkimen | Aysel Gülbandılar

Yayıncı:

Bayburt University

Ana Başlıklar:

Kimya Mühendisliği (Diğer)

Dergi:

Bayburt Üniversitesi Fen Bilimleri Dergisi Vol.7 Issue 2, pp.103-113

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001337020

pISSN:

2667-579X

4,4’-Ethylene dipyridine

2,3-Pyrazine dicarboxylic acid

Metal complex

Antimicrobial activity4,4'-Etilenedipiridin

2,3-Pirazin dikarboksilik asit

Metal kompleksi

Antimikrobiyal aktivite

Sayı

Makale detayları

Yazarlar: Nurgün Büyükkıdan | Seher Kaya | Halil İlkimen | Aysel Gülbandılar

Yayıncı: Bayburt University

Ana Başlıklar: Kimya Mühendisliği (Diğer)

Dergi: Bayburt Üniversitesi Fen Bilimleri Dergisi Vol.7 Issue 2, pp.103-113

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001337020

pISSN: 2667-579X

Sayı

Yazarlar:

Nurgün Büyükkıdan | Seher Kaya | Halil İlkimen | Aysel Gülbandılar

Yayıncı:

Bayburt University

Ana Başlıklar:

Kimya Mühendisliği (Diğer)

Dergi:

Bayburt Üniversitesi Fen Bilimleri Dergisi Vol.7 Issue 2, pp.103-113

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001337020

pISSN:

2667-579X