Predictive value of NLRC3 levels for pulmonary hypertension in patients with chronic obstructive pulmonary disease

Meltem Yılmaz; Levent Cem Mutlu; Şeref Alpsoy; Aydın Akyüz; Aliye Çelikkol; Özlem Kaymaz

Makale detayları

Predictive value of NLRC3 levels for pulmonary hypertension in patients with chronic obstructive pulmonary disease

Yazarlar:

Meltem Yılmaz | Levent Cem Mutlu | Şeref Alpsoy | Aydın Akyüz | Aliye Çelikkol | Özlem Kaymaz

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Chest Diseases

Dergi:

The European Research Journal Vol.10 Issue 3, pp.262-267

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001315669

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: Chronic obstructive pulmonary disease COPD is a medical condition defined by persistent airflow limitation and respiratory symptoms caused by airway andor alveolar abnormalities. Pulmonary hypertension PH is one of the cardiovascular comorbidities associated with COPD. We investigated the correlation of NLRC3 levels in patients with COPD with prognostic and surrogate parameters of PH on echocardiography and examined whether it could be used to predict PH in this patient population. Methods: A total of 80 patients diagnosed with COPD and 40 healthy volunteers as the control group were included in the study. The COPD group was further divided into two subgroups according to the systolic pulmonary artery pressure sPAP as follows: sPAP35 mmHg and sPAP35 mmHg. The enzyme-linked immunosorbent assay ELISA method was used to determine the levels of NLRC3 in peripheral blood. Results: Patients with sPAP35 mmHg had a lower mean NLRC3 level than those with sPAP35 mmHg P0.006. The NLRC3 levels showed a significant negative correlation with sPAP, tricuspid regurgitation velocity, right atrium, and pulmonary artery diameter. For NLRC3, the cut-off value was found to be 271,486 ngL, with a sensitivity of 74, and specificity of 63 in distinguishing patients with sPAP35 mmHg from all patients with sPAP35 mmHg. Conclusions: Our study results suggest that NLRC3 levels measured from peripheral blood are predictive of PH in patients with COPD. Although the exact function of NLRC3 in the lungs, COPD, and PH have not been completely understood, we believe these findings will serve as a model for future studies.

 Objectives: Chronic obstructive pulmonary disease COPD is a medical condition defined by persistent airflow limitation and respiratory symptoms caused by airway andor alveolar abnormalities. Pulmonary hypertension PH is one of the cardiovascular comorbidities associated with COPD. We investigated the correlation of NLRC3 levels in patients with COPD with prognostic and surrogate parameters of PH on echocardiography and examined whether it could be used to predict PH in this patient population. Methods: A total of 80 patients diagnosed with COPD and 40 healthy volunteers as the control group were included in the study. The COPD group was further divided into two subgroups according to the systolic pulmonary artery pressure sPAP as follows: sPAP35 mmHg and sPAP35 mmHg. The enzyme-linked immunosorbent assay ELISA method was used to determine the levels of NLRC3 in peripheral blood. Results: Patients with sPAP35 mmHg had a lower mean NLRC3 level than those with sPAP35 mmHg P0.006. The NLRC3 levels showed a significant negative correlation with sPAP, tricuspid regurgitation velocity, right atrium, and pulmonary artery diameter. For NLRC3, the cut-off value was found to be 271,486 ngL, with a sensitivity of 74, and specificity of 63 in distinguishing patients with sPAP35 mmHg from all patients with sPAP35 mmHg. Conclusions: Our study results suggest that NLRC3 levels measured from peripheral blood are predictive of PH in patients with COPD. Although the exact function of NLRC3 in the lungs, COPD, and PH have not been completely understood, we believe these findings will serve as a model for future studies.

 Objectives: Chronic obstructive pulmonary disease COPD is a medical condition defined by persistent airflow limitation and respiratory symptoms caused by airway andor alveolar abnormalities. Pulmonary hypertension PH is one of the cardiovascular comorbidities associated with COPD. We investigated the correlation of NLRC3 levels in patients with COPD with prognostic and surrogate parameters of PH on echocardiography and examined whether it could be used to predict PH in this patient population. Methods: A total of 80 patients diagnosed with COPD and 40 healthy volunteers as the control group were included in the study. The COPD group was further divided into two subgroups according to the systolic pulmonary artery pressure sPAP as follows: sPAP35 mmHg and sPAP35 mmHg. The enzyme-linked immunosorbent assay ELISA method was used to determine the levels of NLRC3 in peripheral blood. Results: Patients with sPAP35 mmHg had a lower mean NLRC3 level than those with sPAP35 mmHg P0.006. The NLRC3 levels showed a significant negative correlation with sPAP, tricuspid regurgitation velocity, right atrium, and pulmonary artery diameter. For NLRC3, the cut-off value was found to be 271,486 ngL, with a sensitivity of 74, and specificity of 63 in distinguishing patients with sPAP35 mmHg from all patients with sPAP35 mmHg. Conclusions: Our study results suggest that NLRC3 levels measured from peripheral blood are predictive of PH in patients with COPD. Although the exact function of NLRC3 in the lungs, COPD, and PH have not been completely understood, we believe these findings will serve as a model for future studies.

 Objectives: Chronic obstructive pulmonary disease COPD is a medical condition defined by persistent airflow limitation and respiratory symptoms caused by airway andor alveolar abnormalities. Pulmonary hypertension PH is one of the cardiovascular comorbidities associated with COPD. We investigated the correlation of NLRC3 levels in patients with COPD with prognostic and surrogate parameters of PH on echocardiography and examined whether it could be used to predict PH in this patient population. Methods: A total of 80 patients diagnosed with COPD and 40 healthy volunteers as the control group were included in the study. The COPD group was further divided into two subgroups according to the systolic pulmonary artery pressure sPAP as follows: sPAP35 mmHg and sPAP35 mmHg. The enzyme-linked immunosorbent assay ELISA method was used to determine the levels of NLRC3 in peripheral blood. Results: Patients with sPAP35 mmHg had a lower mean NLRC3 level than those with sPAP35 mmHg P0.006. The NLRC3 levels showed a significant negative correlation with sPAP, tricuspid regurgitation velocity, right atrium, and pulmonary artery diameter. For NLRC3, the cut-off value was found to be 271,486 ngL, with a sensitivity of 74, and specificity of 63 in distinguishing patients with sPAP35 mmHg from all patients with sPAP35 mmHg. Conclusions: Our study results suggest that NLRC3 levels measured from peripheral blood are predictive of PH in patients with COPD. Although the exact function of NLRC3 in the lungs, COPD, and PH have not been completely understood, we believe these findings will serve as a model for future studies.

Makale detayları

Predictive value of NLRC3 levels for pulmonary hypertension in patients with chronic obstructive pulmonary disease

Yazarlar: Meltem Yılmaz | Levent Cem Mutlu | Şeref Alpsoy | Aydın Akyüz | Aliye Çelikkol | Özlem Kaymaz

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Chest Diseases

Dergi: The European Research Journal Vol.10 Issue 3, pp.262-267

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001315669

pISSN: 2149-3189

NLRC3

chronic obstructive pulmonary disease

pulmonary hypertension

echocardiography

Sayı

Yazarlar:

Meltem Yılmaz | Levent Cem Mutlu | Şeref Alpsoy | Aydın Akyüz | Aliye Çelikkol | Özlem Kaymaz

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Chest Diseases

Dergi:

The European Research Journal Vol.10 Issue 3, pp.262-267

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001315669

pISSN:

2149-3189