Cholinergic cognitive enhancer effect of Salvia triloba L. essential oil inhalation in rats

Mehmet Ergen; Timur Hakan Barak

Makale detayları

Cholinergic cognitive enhancer effect of Salvia triloba L. essential oil inhalation in rats

Yazarlar:

Mehmet Ergen | Timur Hakan Barak

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.36 Issue 3, pp.361-370

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298911

pISSN:

1019-1941

Anahtar kelimeler:

Özet:

 Objective: Current treatment of Alzheimers disease is provided by cholinesterase inhibitors. Salvia triloba L. syn. Salvia fruticosa Mill., a species mostly consumed as refreshing herbal tea in traditional medicine, is rich in 1,8-cineole that is known to have cholinesterase inhibiting effects. In this study, we investigated cognitive enhancer effects of S. triloba essential oil inhalation on healthy control rats and rats with scopolamine induced memory impairment. Materials and Methods: S. triloba samples from different geographical locations of Turkey were hydro-distilled and analyzed by Gas Chromatography-Mass Spectrometry GC-MS. The optimum sample with the highest 1,8-cineole and lowest camphor, α-thujone and β-thujone content was selected. In vitro cholinergic and antioxidant potentials of the selected essential oil were calculated. Cognitive enhancer and anti-amnestic effects of the inhaled essential oil on rats were assessed by means of Morris water maze. The bioavailability of 1,8-cineole in blood of rats was measured by GC-MS. Results: The group that inhaled S. triloba significantly outperformed control group, namely faster achieving peak escape latency performance in Morris water maze. However, S. triloba inhalation failed to restore scopolamine induced learning impairment. Conclusion: In this study, we report positive effects of inhaling S. triloba essential oil as a complementary treatment for supporting cognitive functions.

 Objective: Current treatment of Alzheimers disease is provided by cholinesterase inhibitors. Salvia triloba L. syn. Salvia fruticosa Mill., a species mostly consumed as refreshing herbal tea in traditional medicine, is rich in 1,8-cineole that is known to have cholinesterase inhibiting effects. In this study, we investigated cognitive enhancer effects of S. triloba essential oil inhalation on healthy control rats and rats with scopolamine induced memory impairment. Materials and Methods: S. triloba samples from different geographical locations of Turkey were hydro-distilled and analyzed by Gas Chromatography-Mass Spectrometry GC-MS. The optimum sample with the highest 1,8-cineole and lowest camphor, α-thujone and β-thujone content was selected. In vitro cholinergic and antioxidant potentials of the selected essential oil were calculated. Cognitive enhancer and anti-amnestic effects of the inhaled essential oil on rats were assessed by means of Morris water maze. The bioavailability of 1,8-cineole in blood of rats was measured by GC-MS. Results: The group that inhaled S. triloba significantly outperformed control group, namely faster achieving peak escape latency performance in Morris water maze. However, S. triloba inhalation failed to restore scopolamine induced learning impairment. Conclusion: In this study, we report positive effects of inhaling S. triloba essential oil as a complementary treatment for supporting cognitive functions.

 Objective: Current treatment of Alzheimers disease is provided by cholinesterase inhibitors. Salvia triloba L. syn. Salvia fruticosa Mill., a species mostly consumed as refreshing herbal tea in traditional medicine, is rich in 1,8-cineole that is known to have cholinesterase inhibiting effects. In this study, we investigated cognitive enhancer effects of S. triloba essential oil inhalation on healthy control rats and rats with scopolamine induced memory impairment. Materials and Methods: S. triloba samples from different geographical locations of Turkey were hydro-distilled and analyzed by Gas Chromatography-Mass Spectrometry GC-MS. The optimum sample with the highest 1,8-cineole and lowest camphor, α-thujone and β-thujone content was selected. In vitro cholinergic and antioxidant potentials of the selected essential oil were calculated. Cognitive enhancer and anti-amnestic effects of the inhaled essential oil on rats were assessed by means of Morris water maze. The bioavailability of 1,8-cineole in blood of rats was measured by GC-MS. Results: The group that inhaled S. triloba significantly outperformed control group, namely faster achieving peak escape latency performance in Morris water maze. However, S. triloba inhalation failed to restore scopolamine induced learning impairment. Conclusion: In this study, we report positive effects of inhaling S. triloba essential oil as a complementary treatment for supporting cognitive functions.

 Objective: Current treatment of Alzheimers disease is provided by cholinesterase inhibitors. Salvia triloba L. syn. Salvia fruticosa Mill., a species mostly consumed as refreshing herbal tea in traditional medicine, is rich in 1,8-cineole that is known to have cholinesterase inhibiting effects. In this study, we investigated cognitive enhancer effects of S. triloba essential oil inhalation on healthy control rats and rats with scopolamine induced memory impairment. Materials and Methods: S. triloba samples from different geographical locations of Turkey were hydro-distilled and analyzed by Gas Chromatography-Mass Spectrometry GC-MS. The optimum sample with the highest 1,8-cineole and lowest camphor, α-thujone and β-thujone content was selected. In vitro cholinergic and antioxidant potentials of the selected essential oil were calculated. Cognitive enhancer and anti-amnestic effects of the inhaled essential oil on rats were assessed by means of Morris water maze. The bioavailability of 1,8-cineole in blood of rats was measured by GC-MS. Results: The group that inhaled S. triloba significantly outperformed control group, namely faster achieving peak escape latency performance in Morris water maze. However, S. triloba inhalation failed to restore scopolamine induced learning impairment. Conclusion: In this study, we report positive effects of inhaling S. triloba essential oil as a complementary treatment for supporting cognitive functions.

Makale detayları

Cholinergic cognitive enhancer effect of Salvia triloba L. essential oil inhalation in rats

Yazarlar:

Mehmet Ergen | Timur Hakan Barak

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.36 Issue 3, pp.361-370

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298911

pISSN:

1019-1941

Cognitive enhancers

Essential oil

Gas chromatography

1

8-Cineole

Antioxidants

Morris water maze

Sayı

Makale detayları

Yazarlar: Mehmet Ergen | Timur Hakan Barak

Yayıncı: Marmara University

Ana Başlıklar: Surgery (Other)

Dergi: Marmara Medical Journal Vol.36 Issue 3, pp.361-370

Belge Tipi: Makale

Yayın Tarihi: 9/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001298911

pISSN: 1019-1941

Sayı

Yazarlar:

Mehmet Ergen | Timur Hakan Barak

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.36 Issue 3, pp.361-370

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298911

pISSN:

1019-1941