Naproxen Derivative Interaction Properties with ct-DNA

Nuriye Akbay; Zeynep Koksal; Tugba Taskin-Tok; Ayse UZGOREN-BARAN

doi:https://doi.org/10.15671/hjbc.517481

Makale detayları

Naproxen Derivative Interaction Properties with ct-DNA

Yazarlar:

Nuriye Akbay | Zeynep Koksal | Tugba Taskin-Tok | Ayse UZGOREN-BARAN

Yayıncı:

Hacettepe University

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Hacettepe Journal of Biology and Chemistry 2019 Vol.47 Issue 2, pp.177-184

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000448397

Sıklık:

Üç Aylık

eISSN:

2687-475X

pISSN:

2687-475X

DOI:

https://doi.org/10.15671/hjbc.517481

Özet:

 


Interaction mode of a naproxen derivative (NH) with ct-DNA was explored by absorption and fluorescence spectroscopy. The experimental results revealed the static quenching as a result of groove binding between the naproxen derivative and ct-DNA. Computational studies were carried out to deeper understanding of the interactions. Molecular docking calculations shown that the interaction between NH and ct-DNA is resulted by groove binding. In addition to spectral data, docking studies revealed that NH-A_DNA and NH-B_DNA complexes had different interaction and conformational trends to each DNA isomer.


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Makale detayları

Naproxen Derivative Interaction Properties with ct-DNA

Yazarlar: Nuriye Akbay | Zeynep Koksal | Tugba Taskin-Tok | Ayse UZGOREN-BARAN

Yayıncı: Hacettepe University

Ana Başlıklar: Uygulamalı fizik

Dergi: Hacettepe Journal of Biology and Chemistry 2019 Vol.47 Issue 2, pp.177-184

Belge Tipi: Makale

Yayın Tarihi: 9/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000448397

Sıklık: Üç Aylık

eISSN: 2687-475X

pISSN: 2687-475X

DOI: https://doi.org/10.15671/hjbc.517481

Sayı

Yazarlar:

Nuriye Akbay | Zeynep Koksal | Tugba Taskin-Tok | Ayse UZGOREN-BARAN

Yayıncı:

Hacettepe University

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Hacettepe Journal of Biology and Chemistry 2019 Vol.47 Issue 2, pp.177-184

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000448397

Sıklık:

Üç Aylık

eISSN:

2687-475X

pISSN:

2687-475X

DOI:

https://doi.org/10.15671/hjbc.517481