Investigation of Extended Spectrum Beta Lactamase Frequency in Escherichia coli and Klebsiella pneumoniae Strains Isolated From Individuals Affected By a Major Earthquake

Hamdullah Suphi Bayraktar; Funda Çimen Açıkgül

Makale detayları

Investigation of Extended Spectrum Beta Lactamase Frequency in Escherichia coli and Klebsiella pneumoniae Strains Isolated From Individuals Affected By a Major Earthquake

Yazarlar:

Hamdullah Suphi Bayraktar | Funda Çimen Açıkgül

Yayıncı:

Kafkas University

Ana Başlıklar:

Klinik Mikrobiyoloji

Dergi:

Kafkas Tıp Bilimleri Dergisi Vol.15 Issue 2, pp.219-228

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357910

pISSN:

2146-2631

Anahtar kelimeler:

Özet:

 Aim: Extended-Spectrum β-Lactamase ESBL - producing Escherichia coli E.coli and Klebsiella pneumoniae K.pneumoniae are threatening pathogens which are more resistant to antibiotics in healthcare settings all around the world. The spread of these pathogens may be triggered by natural disasters such as earthquake and flood. Material and Method: A total of 3129 subjects were included in this study and evaluated retrospectively between January 2023 and July 2024 just before and after a major earthquake. VITEK 2 compact automatized system was used to identify the strains. Extendedspectrum β-lactamase production was determined by double disc synergy test and combine disc synergy test. VITEK 2 compact automatized system was used to determine the antibiotic resistance of strains. All statistical analyses were performed using IBM Statistical Package for Social Sciences SPSS program. Chi-square test was applied in comparing the variables between the groups. Statistical significance threshold was found to be P value of 0.05. Results: Nine hundred and fifty two E.coli and 355 K.pneumoniae strains were isolated from 3129 clinical samples. The 478 E. coli 50.21 and 102 K.pneumoniae strains 28.73 were found to be ESBL-positive. ESBL-producing E.coli strains were mostly resistant to cefuroxime 97.48, ceftriaxone 84.51 and 97.05 resistance rate was determined in ESBL-positive K.pneumoniae strains against ceftriaxone. Conclusion: Although ESBL positivity was high in E.coli strains and not significantly different when compared with literature, it was found to be relatively moderate in K.pneumoniae strains. It can be said that despite the major earthquake disaster, these findings are promising.

 Aim: Extended-Spectrum β-Lactamase ESBL - producing Escherichia coli E.coli and Klebsiella pneumoniae K.pneumoniae are threatening pathogens which are more resistant to antibiotics in healthcare settings all around the world. The spread of these pathogens may be triggered by natural disasters such as earthquake and flood. Material and Method: A total of 3129 subjects were included in this study and evaluated retrospectively between January 2023 and July 2024 just before and after a major earthquake. VITEK 2 compact automatized system was used to identify the strains. Extendedspectrum β-lactamase production was determined by double disc synergy test and combine disc synergy test. VITEK 2 compact automatized system was used to determine the antibiotic resistance of strains. All statistical analyses were performed using IBM Statistical Package for Social Sciences SPSS program. Chi-square test was applied in comparing the variables between the groups. Statistical significance threshold was found to be P value of 0.05. Results: Nine hundred and fifty two E.coli and 355 K.pneumoniae strains were isolated from 3129 clinical samples. The 478 E. coli 50.21 and 102 K.pneumoniae strains 28.73 were found to be ESBL-positive. ESBL-producing E.coli strains were mostly resistant to cefuroxime 97.48, ceftriaxone 84.51 and 97.05 resistance rate was determined in ESBL-positive K.pneumoniae strains against ceftriaxone. Conclusion: Although ESBL positivity was high in E.coli strains and not significantly different when compared with literature, it was found to be relatively moderate in K.pneumoniae strains. It can be said that despite the major earthquake disaster, these findings are promising.

 Aim: Extended-Spectrum β-Lactamase ESBL - producing Escherichia coli E.coli and Klebsiella pneumoniae K.pneumoniae are threatening pathogens which are more resistant to antibiotics in healthcare settings all around the world. The spread of these pathogens may be triggered by natural disasters such as earthquake and flood. Material and Method: A total of 3129 subjects were included in this study and evaluated retrospectively between January 2023 and July 2024 just before and after a major earthquake. VITEK 2 compact automatized system was used to identify the strains. Extendedspectrum β-lactamase production was determined by double disc synergy test and combine disc synergy test. VITEK 2 compact automatized system was used to determine the antibiotic resistance of strains. All statistical analyses were performed using IBM Statistical Package for Social Sciences SPSS program. Chi-square test was applied in comparing the variables between the groups. Statistical significance threshold was found to be P value of 0.05. Results: Nine hundred and fifty two E.coli and 355 K.pneumoniae strains were isolated from 3129 clinical samples. The 478 E. coli 50.21 and 102 K.pneumoniae strains 28.73 were found to be ESBL-positive. ESBL-producing E.coli strains were mostly resistant to cefuroxime 97.48, ceftriaxone 84.51 and 97.05 resistance rate was determined in ESBL-positive K.pneumoniae strains against ceftriaxone. Conclusion: Although ESBL positivity was high in E.coli strains and not significantly different when compared with literature, it was found to be relatively moderate in K.pneumoniae strains. It can be said that despite the major earthquake disaster, these findings are promising.

 Aim: Extended-Spectrum β-Lactamase ESBL - producing Escherichia coli E.coli and Klebsiella pneumoniae K.pneumoniae are threatening pathogens which are more resistant to antibiotics in healthcare settings all around the world. The spread of these pathogens may be triggered by natural disasters such as earthquake and flood. Material and Method: A total of 3129 subjects were included in this study and evaluated retrospectively between January 2023 and July 2024 just before and after a major earthquake. VITEK 2 compact automatized system was used to identify the strains. Extendedspectrum β-lactamase production was determined by double disc synergy test and combine disc synergy test. VITEK 2 compact automatized system was used to determine the antibiotic resistance of strains. All statistical analyses were performed using IBM Statistical Package for Social Sciences SPSS program. Chi-square test was applied in comparing the variables between the groups. Statistical significance threshold was found to be P value of 0.05. Results: Nine hundred and fifty two E.coli and 355 K.pneumoniae strains were isolated from 3129 clinical samples. The 478 E. coli 50.21 and 102 K.pneumoniae strains 28.73 were found to be ESBL-positive. ESBL-producing E.coli strains were mostly resistant to cefuroxime 97.48, ceftriaxone 84.51 and 97.05 resistance rate was determined in ESBL-positive K.pneumoniae strains against ceftriaxone. Conclusion: Although ESBL positivity was high in E.coli strains and not significantly different when compared with literature, it was found to be relatively moderate in K.pneumoniae strains. It can be said that despite the major earthquake disaster, these findings are promising.

Makale detayları

Investigation of Extended Spectrum Beta Lactamase Frequency in Escherichia coli and Klebsiella pneumoniae Strains Isolated From Individuals Affected By a Major Earthquake

Yazarlar:

Hamdullah Suphi Bayraktar | Funda Çimen Açıkgül

Yayıncı:

Kafkas University

Ana Başlıklar:

Klinik Mikrobiyoloji

Dergi:

Kafkas Tıp Bilimleri Dergisi Vol.15 Issue 2, pp.219-228

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357910

pISSN:

2146-2631

ESBL

E.coli

K.pneumoniae

nosocomials; antibiotic resistance

Sayı

Makale detayları

Investigation of Extended Spectrum Beta Lactamase Frequency in Escherichia coli and Klebsiella pneumoniae Strains Isolated From Individuals Affected By a Major Earthquake

Yazarlar: Hamdullah Suphi Bayraktar | Funda Çimen Açıkgül

Yayıncı: Kafkas University

Ana Başlıklar: Klinik Mikrobiyoloji

Dergi: Kafkas Tıp Bilimleri Dergisi Vol.15 Issue 2, pp.219-228

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357910

pISSN: 2146-2631

ESBL

E.coli

K.pneumoniae

nosocomials; antibiotic resistance

Sayı

Yazarlar:

Hamdullah Suphi Bayraktar | Funda Çimen Açıkgül

Yayıncı:

Kafkas University

Ana Başlıklar:

Klinik Mikrobiyoloji

Dergi:

Kafkas Tıp Bilimleri Dergisi Vol.15 Issue 2, pp.219-228

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357910

pISSN:

2146-2631