Immunomodulatory    Potential    of    a    Marine    Sponge    Spongosorites   halichondrioides (Dendy, 1905)

Maushmi S. KUMAR; Dipa DESAİ; A.k. PAL

Makale detayları

Immunomodulatory Potential of a Marine Sponge Spongosorites halichondrioides (Dendy, 1905)

Yazarlar:

Maushmi S. KUMAR | Dipa DESAİ | A.k. PAL

Yayıncı:

Trabzon Su Ürünleri Merkez Araştırma Enstitüsü

Dergi:

Turkish Journal of Fisheries and Aquatic Sciences 2012 Vol.12 Issue 1, pp.67-71

Belge Tipi:

Makale

Yayın Tarihi:

1/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000838322

Sıklık:

Üç Aylık

pISSN:

1303-2712

Özet:

 

Marine sponges are animals belonging to the Phylum Porifera. They are well known for its medicinal value. However,   to prove its efficiency for the clinical utilization, more experimental data will be beneficial. The present study involved the   investigation  of  immunomodulatory  activities  of  methanolic  extract  of  marine  sponge  Spongosorites  halichondriodes  from   western coast of India. The extract was studied for acute toxicity (OECD-425 guideline), Haemagglutinating antibody (HA)   titre,   delayed-type    hypersensitivity    (DTH)   response    and    cyclophosphamide-induced    myelosuppression    for   their   immunomodulatory potential. The evaluation of immunomodulatory potential by oral administration of methanolic extract of   marine sponge (200 mg/kg) evoked a significant decrease in total WBC count as compared to control, in antibody titre values,   and  also in  delayed  type  hypersensitivity  reaction induced by  sheep red  blood  cells.  Also  it  prevented  myelosuppression in   cyclophosphamide  drug  treated  rats.  The  results  obtained  in  the  present  study  indicated  that  extract  of  marine  sponge   Spongosorites   halichondrioides  possesses  immunosuppressant  activity  and  can  be  studied  further  for  isolation  of  the   compounds which can be used for organ rejection purpose in future. 	 	 		 .

Makale detayları

Immunomodulatory Potential of a Marine Sponge Spongosorites halichondrioides (Dendy, 1905)

Yazarlar: Maushmi S. KUMAR | Dipa DESAİ | A.k. PAL

Yayıncı: Trabzon Su Ürünleri Merkez Araştırma Enstitüsü

Dergi: Turkish Journal of Fisheries and Aquatic Sciences 2012 Vol.12 Issue 1, pp.67-71

Belge Tipi: Makale

Yayın Tarihi: 1/2012

Belge Dili: Türkçe

Document ID (Org No.): 2000838322

Sıklık: Üç Aylık

pISSN: 1303-2712

Sayı

Yazarlar:

Maushmi S. KUMAR | Dipa DESAİ | A.k. PAL

Yayıncı:

Trabzon Su Ürünleri Merkez Araştırma Enstitüsü

Dergi:

Turkish Journal of Fisheries and Aquatic Sciences 2012 Vol.12 Issue 1, pp.67-71

Belge Tipi:

Makale

Yayın Tarihi:

1/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000838322

Sıklık:

Üç Aylık

pISSN:

1303-2712