Potency of tamoxifen against clinical isolates of Candida resistant to itraconazole

N.A.

Makale detayları

Potency of tamoxifen against clinical isolates of Candida resistant to itraconazole

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 6, pp.2530-2534

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346316

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Tamoxifen TAM has been shown to have an antifungal action along with its anticancer activity. Various species of fungi have shown varying susceptibility to TAM. The antifungal activity of TAM was studied against clinical pathogenic species of Candida that are resistant to itraconazole through using disk diffusion and dilution methods. Of 50 isolates of Candida from women with vulvovaginal candidiasis, 15 isolates were resistant to itraconazole. These isolates consisted of four isolates of C. albicans, ten isolates of C. glabrata and one isolate of C. utilis. All isolates were inhibited by a high concentration of TAM 20 mgml. Candida albicans was affected by TAM at10 mgml MIC, 5.5-7 mgml. High susceptibility with a low MIC value of TAM 3 mgml was observed in Candida glabrata isolates. Candida utilis was also found to be the isolate with the highest resistance to TAM MIC, 15 mgml. In conclusion; TAM is an effective agent against drug-resistant species of Candida in high concentrations. It was also demonstrated that resistant isolates of C. glabrata are the most susceptible to TAM. High-dose of TAM is recommended for the treatment of fungal infections caused by drug-resistant species of Candida. Further studies are needed in this concern.

 Tamoxifen TAM has been shown to have an antifungal action along with its anticancer activity. Various species of fungi have shown varying susceptibility to TAM. The antifungal activity of TAM was studied against clinical pathogenic species of Candida that are resistant to itraconazole through using disk diffusion and dilution methods. Of 50 isolates of Candida from women with vulvovaginal candidiasis, 15 isolates were resistant to itraconazole. These isolates consisted of four isolates of C. albicans, ten isolates of C. glabrata and one isolate of C. utilis. All isolates were inhibited by a high concentration of TAM 20 mgml. Candida albicans was affected by TAM at10 mgml MIC, 5.5-7 mgml. High susceptibility with a low MIC value of TAM 3 mgml was observed in Candida glabrata isolates. Candida utilis was also found to be the isolate with the highest resistance to TAM MIC, 15 mgml. In conclusion; TAM is an effective agent against drug-resistant species of Candida in high concentrations. It was also demonstrated that resistant isolates of C. glabrata are the most susceptible to TAM. High-dose of TAM is recommended for the treatment of fungal infections caused by drug-resistant species of Candida. Further studies are needed in this concern.

 Tamoxifen TAM has been shown to have an antifungal action along with its anticancer activity. Various species of fungi have shown varying susceptibility to TAM. The antifungal activity of TAM was studied against clinical pathogenic species of Candida that are resistant to itraconazole through using disk diffusion and dilution methods. Of 50 isolates of Candida from women with vulvovaginal candidiasis, 15 isolates were resistant to itraconazole. These isolates consisted of four isolates of C. albicans, ten isolates of C. glabrata and one isolate of C. utilis. All isolates were inhibited by a high concentration of TAM 20 mgml. Candida albicans was affected by TAM at10 mgml MIC, 5.5-7 mgml. High susceptibility with a low MIC value of TAM 3 mgml was observed in Candida glabrata isolates. Candida utilis was also found to be the isolate with the highest resistance to TAM MIC, 15 mgml. In conclusion; TAM is an effective agent against drug-resistant species of Candida in high concentrations. It was also demonstrated that resistant isolates of C. glabrata are the most susceptible to TAM. High-dose of TAM is recommended for the treatment of fungal infections caused by drug-resistant species of Candida. Further studies are needed in this concern.

 Tamoxifen TAM has been shown to have an antifungal action along with its anticancer activity. Various species of fungi have shown varying susceptibility to TAM. The antifungal activity of TAM was studied against clinical pathogenic species of Candida that are resistant to itraconazole through using disk diffusion and dilution methods. Of 50 isolates of Candida from women with vulvovaginal candidiasis, 15 isolates were resistant to itraconazole. These isolates consisted of four isolates of C. albicans, ten isolates of C. glabrata and one isolate of C. utilis. All isolates were inhibited by a high concentration of TAM 20 mgml. Candida albicans was affected by TAM at10 mgml MIC, 5.5-7 mgml. High susceptibility with a low MIC value of TAM 3 mgml was observed in Candida glabrata isolates. Candida utilis was also found to be the isolate with the highest resistance to TAM MIC, 15 mgml. In conclusion; TAM is an effective agent against drug-resistant species of Candida in high concentrations. It was also demonstrated that resistant isolates of C. glabrata are the most susceptible to TAM. High-dose of TAM is recommended for the treatment of fungal infections caused by drug-resistant species of Candida. Further studies are needed in this concern.

Makale detayları

Potency of tamoxifen against clinical isolates of Candida resistant to itraconazole

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 6, pp.2530-2534

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346316

pISSN:

2630-6344

Candida

Itraconazole

Tamoxifen

Resistant

Sayı

Makale detayları

Potency of tamoxifen against clinical isolates of Candida resistant to itraconazole

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.27 Issue 6, pp.2530-2534

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346316

pISSN: 2630-6344

Candida

Itraconazole

Tamoxifen

Resistant

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 6, pp.2530-2534

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346316

pISSN:

2630-6344