Takayasu arteritis: an update

Gökhan KESER; Kenan AKSU; Rafi Haner DİRESKENELİ

Makale detayları

Takayasu arteritis: an update

Yazarlar:

Gökhan KESER | Kenan AKSU | Rafi Haner DİRESKENELİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 4, pp.681-697

Belge Tipi:

Makale

Yayın Tarihi:

7/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750602

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Takayasu arteritis (TAK) is a challenging chronic, granulomatous, large-vessel systemic vasculitis, mostly due to difficulties in  early diagnosis and assessing actual disease activity. Since there are no specific diagnostic laboratory tests, biomarkers, or autoantibodies,  many patients experience considerable delay in diagnosis. Remembering the possibility of TAK together with the use of acute phase  responses and appropriate imaging studies may be helpful for early diagnosis. Since there may be discrepancies between systemic and  vascular wall inflammation, using only acute phase responses is not reliable in assessing current disease activity. Therefore, physical  examination and new imaging findings should also be used to assess current disease activity. Despite its limitations, the Indian Takayasu  Clinical Activity Score (ITAS2010) may also be helpful for this purpose. The rationale of medical treatment is to suppress both vascular and  systemic inflammation with appropriate systemic immunosuppression, including corticosteroids and conventional immunosuppressive  agents. In cases of refractory disease activity, leflunomide and biologic agents such as TNF inhibitors and tocilizumab may be tried.  In selected cases with persistent lesions that cannot be reversed with medical treatment, endovascular interventions including balloon  angioplasty, stent and stent graft replacement, or surgery may be tried. However, such procedures should be performed after suppression  of inflammation, i.e. during inactive disease. Prognosis of TAK is probably getting better with lower mortality rates reported in recent  years, probably due to the use of more effective medical treatments as well as the use of endovascular interventions when necessary and  available.

Makale detayları

Takayasu arteritis: an update

Yazarlar: Gökhan KESER | Kenan AKSU | Rafi Haner DİRESKENELİ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 4, pp.681-697

Belge Tipi: Makale

Yayın Tarihi: 7/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000750602

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Gökhan KESER | Kenan AKSU | Rafi Haner DİRESKENELİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 4, pp.681-697

Belge Tipi:

Makale

Yayın Tarihi:

7/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750602

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144