Effect of a tropical plant (Hunteria umbellata) in the management of Streptozotocin induced Diabetes Mellitus and other physiological and biochemical functions in Wistar

Fidelis OKOLAFOR; Frederick EKHAISE

doi:https://doi.org/10.38093/cupmap.842583

Makale detayları

Effect of a tropical plant (Hunteria umbellata) in the management of Streptozotocin induced Diabetes Mellitus and other physiological and biochemical functions in Wistar

Yazarlar:

Fidelis OKOLAFOR | Frederick EKHAISE

Yayıncı:

Nazım ŞEKEROĞLU

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

Current Perspectives on Medicinal and Aromatic Plants 2021 Vol.4 Issue 1, pp.1-12

Belge Tipi:

Makale

Yayın Tarihi:

5/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000925536

Sıklık:

İki Yıllık

eISSN:

2667-5722

pISSN:

2619-9645

DOI:

https://doi.org/10.38093/cupmap.842583

Özet:

 

The antidiabetic effect of Hunteria umbellata extracts (aqueous and methanol) on hematological, lipid profile and biochemical parameters in streptozotocin-induced diabetes in female wistar rats was studied. The phytochemical screening of the seed extracts was determined using standard chemical methods. Twenty five (25) wistar rats weighing between 117g and 170g were shared into five (5) groups of five animals per group for the physiological studies. All treatment groups were administered 500 mg/kg per body weight of H. umbellata extracts. Group 1: normal control, group 2: negative or diabetic control, group 3: metformin + streptozotocin (STZ), group 4: aqueous extract of H. umbellata + STZ and group 5: methanol extract of H. umbellata + STZ. Diabetes was induced with 55mg/kg body weight streptozotocin (STZ). Quantitative phytochemical screening of aqueous and methanol seed extracts of H. umbellata reviewed the presence of secondary metabolites such as, saponins, phytate, oxalate, anthraquinones, Cyanogenic glycoside; where phenols and alkaloids recorded highest concentrations in both extracts. The hypoglycaemic studies of methanol extract revealed significant (p0.05) for all treatment groups. Group 5 recorded significance (p<0.05) amount of high density lipoproteins (HDL), total cholesterol (CHOL), triglyceride (TRIG) and low density lipoproteins (LDL) while CHOL was significant (p<0.05) for group 3. The biochemical parameters were within safe limit. The methanol extract of H. umbellata possesses the potentials for the managements of blood glucose levels compared to conventional drug (metformin).

Makale detayları

Effect of a tropical plant (Hunteria umbellata) in the management of Streptozotocin induced Diabetes Mellitus and other physiological and biochemical functions in Wistar

Yazarlar: Fidelis OKOLAFOR | Frederick EKHAISE

Yayıncı: Nazım ŞEKEROĞLU

Ana Başlıklar: Farmakoloji ve terapötik

Dergi: Current Perspectives on Medicinal and Aromatic Plants 2021 Vol.4 Issue 1, pp.1-12

Belge Tipi: Makale

Yayın Tarihi: 5/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000925536

Sıklık: İki Yıllık

eISSN: 2667-5722

pISSN: 2619-9645

DOI: https://doi.org/10.38093/cupmap.842583

Sayı

Yazarlar:

Fidelis OKOLAFOR | Frederick EKHAISE

Yayıncı:

Nazım ŞEKEROĞLU

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

Current Perspectives on Medicinal and Aromatic Plants 2021 Vol.4 Issue 1, pp.1-12

Belge Tipi:

Makale

Yayın Tarihi:

5/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000925536

Sıklık:

İki Yıllık

eISSN:

2667-5722

pISSN:

2619-9645

DOI:

https://doi.org/10.38093/cupmap.842583