Reduction of salivary tumor necrosis factor alpha levels in  response to magic mouthwash with Curcuma xanthorriza  in cancer patients undergoing chemotherapy

Irna Sufiawati

Makale detayları

Reduction of salivary tumor necrosis factor alpha levels in response to magic mouthwash with Curcuma xanthorriza in cancer patients undergoing chemotherapy

Yazarlar:

Irna Sufiawati

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 1, pp.55-61

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346126

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Tumor necrosis factor-alpha TNF-α is pro-inflammatory cytokine that play a key role in initiating and accelerating the development of oral mucositis in cancer patients undergoing chemotherapy. Mixed medication mouthwash called magic mouthwash has been widely used to prevent and treat oral mucositis. Curcuma xanthorriza is a traditional herbal medicine, which has shown anti-inflammatory, antibacterial, and antifungal effects. The aim of this study was to evaluate the effect of magic mouthwash with Curcuma xanthorriza on salivary TNF-α levels in cancer patients undergoing chemotherapy. The magic mouthwash formulation used in this study contains diphenhydramine, hydrocortisone, nystatin and dry curcuma extract. This study involved 60 cancer patients undergoing 5-Fluorouracil 5 FU-based chemotherapy who were assigned into two groups, each group consisted of 30 patients. Group 1 instructed for rinsing with magic mouthwash with Curcuma xanthorriza and group 2 rinsed with NaCl 0.9 as control group. Unstimulated whole saliva was collected before and after oral rinsing with mouthwashes. Salivary TNF-α levels were measured with enzyme linked immunosorbent assay ELISA. Data were analyzed statistically with Wilcoxon and Chi square test. The result of this study showed a significant decrease in salivary TNF-α levels on both groups p0.05. In the study group, more patients were found with salivary TNF-α levels decreased 74.2 compared to control group 53.5 and showed significant difference statistically p0.05. The study concludes that magic mouthwash with Curcuma xanthorriza can reduce Salivary TNF-α levels and can be used as an alternative therapy for oral mucositis induced chemotherapy.

 Tumor necrosis factor-alpha TNF-α is pro-inflammatory cytokine that play a key role in initiating and accelerating the development of oral mucositis in cancer patients undergoing chemotherapy. Mixed medication mouthwash called magic mouthwash has been widely used to prevent and treat oral mucositis. Curcuma xanthorriza is a traditional herbal medicine, which has shown anti-inflammatory, antibacterial, and antifungal effects. The aim of this study was to evaluate the effect of magic mouthwash with Curcuma xanthorriza on salivary TNF-α levels in cancer patients undergoing chemotherapy. The magic mouthwash formulation used in this study contains diphenhydramine, hydrocortisone, nystatin and dry curcuma extract. This study involved 60 cancer patients undergoing 5-Fluorouracil 5 FU-based chemotherapy who were assigned into two groups, each group consisted of 30 patients. Group 1 instructed for rinsing with magic mouthwash with Curcuma xanthorriza and group 2 rinsed with NaCl 0.9 as control group. Unstimulated whole saliva was collected before and after oral rinsing with mouthwashes. Salivary TNF-α levels were measured with enzyme linked immunosorbent assay ELISA. Data were analyzed statistically with Wilcoxon and Chi square test. The result of this study showed a significant decrease in salivary TNF-α levels on both groups p0.05. In the study group, more patients were found with salivary TNF-α levels decreased 74.2 compared to control group 53.5 and showed significant difference statistically p0.05. The study concludes that magic mouthwash with Curcuma xanthorriza can reduce Salivary TNF-α levels and can be used as an alternative therapy for oral mucositis induced chemotherapy.

 Tumor necrosis factor-alpha TNF-α is pro-inflammatory cytokine that play a key role in initiating and accelerating the development of oral mucositis in cancer patients undergoing chemotherapy. Mixed medication mouthwash called magic mouthwash has been widely used to prevent and treat oral mucositis. Curcuma xanthorriza is a traditional herbal medicine, which has shown anti-inflammatory, antibacterial, and antifungal effects. The aim of this study was to evaluate the effect of magic mouthwash with Curcuma xanthorriza on salivary TNF-α levels in cancer patients undergoing chemotherapy. The magic mouthwash formulation used in this study contains diphenhydramine, hydrocortisone, nystatin and dry curcuma extract. This study involved 60 cancer patients undergoing 5-Fluorouracil 5 FU-based chemotherapy who were assigned into two groups, each group consisted of 30 patients. Group 1 instructed for rinsing with magic mouthwash with Curcuma xanthorriza and group 2 rinsed with NaCl 0.9 as control group. Unstimulated whole saliva was collected before and after oral rinsing with mouthwashes. Salivary TNF-α levels were measured with enzyme linked immunosorbent assay ELISA. Data were analyzed statistically with Wilcoxon and Chi square test. The result of this study showed a significant decrease in salivary TNF-α levels on both groups p0.05. In the study group, more patients were found with salivary TNF-α levels decreased 74.2 compared to control group 53.5 and showed significant difference statistically p0.05. The study concludes that magic mouthwash with Curcuma xanthorriza can reduce Salivary TNF-α levels and can be used as an alternative therapy for oral mucositis induced chemotherapy.

 Tumor necrosis factor-alpha TNF-α is pro-inflammatory cytokine that play a key role in initiating and accelerating the development of oral mucositis in cancer patients undergoing chemotherapy. Mixed medication mouthwash called magic mouthwash has been widely used to prevent and treat oral mucositis. Curcuma xanthorriza is a traditional herbal medicine, which has shown anti-inflammatory, antibacterial, and antifungal effects. The aim of this study was to evaluate the effect of magic mouthwash with Curcuma xanthorriza on salivary TNF-α levels in cancer patients undergoing chemotherapy. The magic mouthwash formulation used in this study contains diphenhydramine, hydrocortisone, nystatin and dry curcuma extract. This study involved 60 cancer patients undergoing 5-Fluorouracil 5 FU-based chemotherapy who were assigned into two groups, each group consisted of 30 patients. Group 1 instructed for rinsing with magic mouthwash with Curcuma xanthorriza and group 2 rinsed with NaCl 0.9 as control group. Unstimulated whole saliva was collected before and after oral rinsing with mouthwashes. Salivary TNF-α levels were measured with enzyme linked immunosorbent assay ELISA. Data were analyzed statistically with Wilcoxon and Chi square test. The result of this study showed a significant decrease in salivary TNF-α levels on both groups p0.05. In the study group, more patients were found with salivary TNF-α levels decreased 74.2 compared to control group 53.5 and showed significant difference statistically p0.05. The study concludes that magic mouthwash with Curcuma xanthorriza can reduce Salivary TNF-α levels and can be used as an alternative therapy for oral mucositis induced chemotherapy.

Makale detayları

Reduction of salivary tumor necrosis factor alpha levels in response to magic mouthwash with Curcuma xanthorriza in cancer patients undergoing chemotherapy

Yazarlar:

Irna Sufiawati

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 1, pp.55-61

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346126

pISSN:

2630-6344

Chemotherapy

Curcuma xanthorriza

magic mouthwash

salivary TNF-α

Sayı

Makale detayları

Reduction of salivary tumor necrosis factor alpha levels in response to magic mouthwash with Curcuma xanthorriza in cancer patients undergoing chemotherapy

Yazarlar: Irna Sufiawati

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Sciences

Dergi: Journal of Research in Pharmacy Vol.23 Issue 1, pp.55-61

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346126

pISSN: 2630-6344

Chemotherapy

Curcuma xanthorriza

magic mouthwash

salivary TNF-α

Sayı

Yazarlar:

Irna Sufiawati

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 1, pp.55-61

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346126

pISSN:

2630-6344