Differential diagnosis of papillary thyroid carcinoma: Immunocytochemical study of 112 cases

Mustafa KÖSEM; Sabriye POLAT; Mustafa ÖZTÜRK; Çetin KOTAN; Hanefi ÖZBEK; Ekrem ALGÜN

Makale detayları

Differential diagnosis of papillary thyroid carcinoma: Immunocytochemical study of 112 cases

Yazarlar:

Mustafa KÖSEM | Sabriye POLAT | Mustafa ÖZTÜRK | Çetin KOTAN | Hanefi ÖZBEK | Ekrem ALGÜN

Yayıncı:

Van Yuzuncu Yıl University

Dergi:

EASTERN JOURNAL OF MEDICINE 2005 Vol.10 Issue 1-2, pp.1-19

Belge Tipi:

Makale

Yayın Tarihi:

3/2013

Belge Dili:

İngilizce

Document ID (Org No.):

2000773355

Sıklık:

Aylık

eISSN:

1301-0883

pISSN:

1301-0883

Özet:

 


Abstract. Papillary carcinoma is diagnosed mainly by its classical papillary structures and nuclear changes. However similar structural and cytological features may also be seen in other lesions of thyroid. Immunohistochemical staining methods help in these circumstances that cytological features do not suffice for differential diagnosis. In this study we stained 112 parafin-embedded blocks with thyroidal lesions (60 papillary carcinoma and 52 other benign or malignant thyroidal lesions) with HBME-1, CK-19, S-100 and EMA. Papillary carcinomas were stained 8.3% weakly, 90% moderately  and strongly with HBME-1; 11.7% weakly, 88.3% moderately and strongly with CK-19; 50% weakly, 50% moderately and strongly with EMA; 26.6% weakly, 48.4% moderately and strongly with S-100. Other thyroid lesions were stained 36.5% weakly, 5.8% moderately with CK-19; 26.6% weakly, 15.4% moderately with EMA; 7.7% weakly, 1.9% moderately with S-100. None of the thyroid lesions, but papillary carcinoma, were stained with HBME-1. Papillary carcinoma cases had significantly higher staining with all four markers. However, HBME-1 and CK-19 were considered more valuable in differential diagnosis for papillary carcinomas, since they showed moderate and strong staining. Also high sensitivity and specificity of HBME-1 makes it a good marker for the diagnosis of papillary thyroid cancer.

Keywords: Papillary thyroid carcinoma, HBME-1, CK-19, S-100, EMA

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Makale detayları

Differential diagnosis of papillary thyroid carcinoma: Immunocytochemical study of 112 cases

Yazarlar: Mustafa KÖSEM | Sabriye POLAT | Mustafa ÖZTÜRK | Çetin KOTAN | Hanefi ÖZBEK | Ekrem ALGÜN

Yayıncı: Van Yuzuncu Yıl University

Dergi: EASTERN JOURNAL OF MEDICINE 2005 Vol.10 Issue 1-2, pp.1-19

Belge Tipi: Makale

Yayın Tarihi: 3/2013

Belge Dili: İngilizce

Document ID (Org No.): 2000773355

Sıklık: Aylık

eISSN: 1301-0883

pISSN: 1301-0883

Sayı

Yazarlar:

Mustafa KÖSEM | Sabriye POLAT | Mustafa ÖZTÜRK | Çetin KOTAN | Hanefi ÖZBEK | Ekrem ALGÜN

Yayıncı:

Van Yuzuncu Yıl University

Dergi:

EASTERN JOURNAL OF MEDICINE 2005 Vol.10 Issue 1-2, pp.1-19

Belge Tipi:

Makale

Yayın Tarihi:

3/2013

Belge Dili:

İngilizce

Document ID (Org No.):

2000773355

Sıklık:

Aylık

eISSN:

1301-0883

pISSN:

1301-0883