The Effects of Indomethacin, Furosemide and Prostaglandin F2 alpha on Thyroid Hormone Levels in Rams

İzzet KARAHAN; İbrahim PİRİNÇCİ; Ahmet ATEŞŞAHİN

Makale detayları

The Effects of Indomethacin, Furosemide and Prostaglandin F2 alpha on Thyroid Hormone Levels in Rams

Yazarlar:

İzzet KARAHAN | İbrahim PİRİNÇCİ | Ahmet ATEŞŞAHİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2002 Vol.26 Issue 6, pp.1375-1380

Belge Tipi:

Makale

Yayın Tarihi:

5/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000770437

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Anahtar kelimeler:

Özet:

 

This study was carried out to investigate the changes occurring in the levels of serum thyroid hormone in rams given indomethacin, furosemide and PGF2a. In the study, 20 Akkaraman rams, approximately 2 years old were used. Indomethacin (3.0 mg/kg), furosemide (2.0 mg/kg) and PGF2a (0.1 mg/kg) were intramuscularly given to the animals in one dose and repeated for four consecutive days. Blood samples were collected after drug administrations. Free-total thyriiodothyrionine and thyroxine (T3 and T4) levels were determined using a hormone autoanalyser.  Serum free T3 and T4 levels in rams given PGF2a were found to have fallen compared to the control group and found to have increased in rams given indomethacin . On the other hand, it was established that serum total T3 and T4 levels increased in the rams given furosemide or PGF2a, but  total T3 and T4 levels did not change in the animals given indomethacin. In conclusion, indomethacin, furosemide and PGF2a were found to have an effect on the levels of serum thyroid hormones in the rams.

 

This study was carried out to investigate the changes occurring in the levels of serum thyroid hormone in rams given indomethacin, furosemide and PGF2a. In the study, 20 Akkaraman rams, approximately 2 years old were used. Indomethacin (3.0 mg/kg), furosemide (2.0 mg/kg) and PGF2a (0.1 mg/kg) were intramuscularly given to the animals in one dose and repeated for four consecutive days. Blood samples were collected after drug administrations. Free-total thyriiodothyrionine and thyroxine (T3 and T4) levels were determined using a hormone autoanalyser.  Serum free T3 and T4 levels in rams given PGF2a were found to have fallen compared to the control group and found to have increased in rams given indomethacin . On the other hand, it was established that serum total T3 and T4 levels increased in the rams given furosemide or PGF2a, but  total T3 and T4 levels did not change in the animals given indomethacin. In conclusion, indomethacin, furosemide and PGF2a were found to have an effect on the levels of serum thyroid hormones in the rams.

Makale detayları

The Effects of Indomethacin, Furosemide and Prostaglandin F2 alpha on Thyroid Hormone Levels in Rams

Yazarlar:

İzzet KARAHAN | İbrahim PİRİNÇCİ | Ahmet ATEŞŞAHİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2002 Vol.26 Issue 6, pp.1375-1380

Belge Tipi:

Makale

Yayın Tarihi:

5/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000770437

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Prostaglandin F2 alpha

Furosemide

Indomethacin

Thyroid Hormones

Sayı

Makale detayları

The Effects of Indomethacin, Furosemide and Prostaglandin F2 alpha on Thyroid Hormone Levels in Rams

Yazarlar: İzzet KARAHAN | İbrahim PİRİNÇCİ | Ahmet ATEŞŞAHİN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Veterinary and Animal Sciences 2002 Vol.26 Issue 6, pp.1375-1380

Belge Tipi: Makale

Yayın Tarihi: 5/2002

Belge Dili: Türkçe

Document ID (Org No.): 2000770437

Sıklık: İki Aylık

eISSN: 1303-6181

pISSN: 1300-0128

Prostaglandin F2 alpha

Furosemide

Indomethacin

Thyroid Hormones

Sayı

Yazarlar:

İzzet KARAHAN | İbrahim PİRİNÇCİ | Ahmet ATEŞŞAHİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2002 Vol.26 Issue 6, pp.1375-1380

Belge Tipi:

Makale

Yayın Tarihi:

5/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000770437

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128