The Role of Inflammatory Indices in Predicting Pancreatic Fistula  After Distal Pancreatectomy

Gökay Çetinkaya; Ahmet Cihangir Emral; Mustafa Kerem

Makale detayları

The Role of Inflammatory Indices in Predicting Pancreatic Fistula After Distal Pancreatectomy

Yazarlar:

Gökay Çetinkaya | Ahmet Cihangir Emral | Mustafa Kerem

Yayıncı:

Harran University

Ana Başlıklar:

Genel Cerrahi

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 2, pp.255-259

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343950

pISSN:

1304-9623

Anahtar kelimeler:

Özet:

 Background: The significance of inflammatory markers in forecasting pancreatic fistula development has not been thoroughly investigated in patients who have undergone distal pancreatectomy. This study seeks to assess the predictive value of postoperative inflammatory indices, particularly SII systemic immune inflammation index, NLR neutrophil-to-lymphocyte ratio and PLR platelet-to-lymphocyte ratio, concerning the onset of pancreatic fistula in these patients. Materials and Methods: This retrospective study analyzed patients who underwent distal pancreatec-tomy for pancreatic cancer between January 2020 and December 2023. Statistical analyses were performed by retrospectively examining the data obtained from the prospectively filled clinical notes of patients who developed pancreatic fistula Grade B and C using the SII, NLR and PLR calculated based on the laboratory results obtained on the third postoperative day. Results: The study included 72 patients who fulfilled the established criteria. Pancreatic fistulas were observed in 25 34.7 of the patients. In this study, BMI and soft pancreatic tissue were statistically significant risk factors for pancreatic fistula development p0.02 for both. SII and NLR from the third postoperative day were statistically significant predictors of pancreatic fistula development, while postoperative PLR did not provide statistically significant results. SII was a more significant predictor of pancreatic fistula than NLR. Conclusions: This study conveys that monitoring the increase in SII and NLR, which are inflammation-related indices, is an effective method for predicting the development of pancreatic fistula after distal pancreatectomy, whereas PLR is not effective in predicting the development of pancreatic fistula.

 Background: The significance of inflammatory markers in forecasting pancreatic fistula development has not been thoroughly investigated in patients who have undergone distal pancreatectomy. This study seeks to assess the predictive value of postoperative inflammatory indices, particularly SII systemic immune inflammation index, NLR neutrophil-to-lymphocyte ratio and PLR platelet-to-lymphocyte ratio, concerning the onset of pancreatic fistula in these patients. Materials and Methods: This retrospective study analyzed patients who underwent distal pancreatec-tomy for pancreatic cancer between January 2020 and December 2023. Statistical analyses were performed by retrospectively examining the data obtained from the prospectively filled clinical notes of patients who developed pancreatic fistula Grade B and C using the SII, NLR and PLR calculated based on the laboratory results obtained on the third postoperative day. Results: The study included 72 patients who fulfilled the established criteria. Pancreatic fistulas were observed in 25 34.7 of the patients. In this study, BMI and soft pancreatic tissue were statistically significant risk factors for pancreatic fistula development p0.02 for both. SII and NLR from the third postoperative day were statistically significant predictors of pancreatic fistula development, while postoperative PLR did not provide statistically significant results. SII was a more significant predictor of pancreatic fistula than NLR. Conclusions: This study conveys that monitoring the increase in SII and NLR, which are inflammation-related indices, is an effective method for predicting the development of pancreatic fistula after distal pancreatectomy, whereas PLR is not effective in predicting the development of pancreatic fistula.

 Background: The significance of inflammatory markers in forecasting pancreatic fistula development has not been thoroughly investigated in patients who have undergone distal pancreatectomy. This study seeks to assess the predictive value of postoperative inflammatory indices, particularly SII systemic immune inflammation index, NLR neutrophil-to-lymphocyte ratio and PLR platelet-to-lymphocyte ratio, concerning the onset of pancreatic fistula in these patients. Materials and Methods: This retrospective study analyzed patients who underwent distal pancreatec-tomy for pancreatic cancer between January 2020 and December 2023. Statistical analyses were performed by retrospectively examining the data obtained from the prospectively filled clinical notes of patients who developed pancreatic fistula Grade B and C using the SII, NLR and PLR calculated based on the laboratory results obtained on the third postoperative day. Results: The study included 72 patients who fulfilled the established criteria. Pancreatic fistulas were observed in 25 34.7 of the patients. In this study, BMI and soft pancreatic tissue were statistically significant risk factors for pancreatic fistula development p0.02 for both. SII and NLR from the third postoperative day were statistically significant predictors of pancreatic fistula development, while postoperative PLR did not provide statistically significant results. SII was a more significant predictor of pancreatic fistula than NLR. Conclusions: This study conveys that monitoring the increase in SII and NLR, which are inflammation-related indices, is an effective method for predicting the development of pancreatic fistula after distal pancreatectomy, whereas PLR is not effective in predicting the development of pancreatic fistula.

 Amaç: İnflamatuar belirteçlerin, distal pankreatektomi sonrası pankreatik fistül gelişimini tahmin etmedeki önemi, bu konuda yapılan çalışmalarla yeterince derinlemesine incelenmemiştir. Bu çalış-ma, distal pankreatektomi yapılan hastalarda postoperatif inflamatuar indekslerin, özellikle SII siste-mik immün inflamasyon indeksi, NLR nötrofil-lenfosit oranı ve PLR trombosit-lenfosit oranı, pank-reatik fistül gelişimi ile ilişkisini değerlendirmeyi amaçlamaktadır. Materyal ve Metod: Bu retrospektif çalışmada, Ocak 2020 ile Aralık 2023 arasında pankreatik kanser nedeniyle distal pankreatektomi uygulanan hastalar analiz edilmiştir. İstatistiksel analizler, pankreatik fistül B ve C dereceleri gelişen hastaların, üçüncü postoperatif günde elde edilen laboratuvar sonuç-larına dayalı olarak hesaplanan SII, NLR ve PLR verileri retrospektif olarak incelenerek yapılmıştır. Bulgular: Çalışmaya, belirlenen kriterlere uyan 72 hasta dahil edildi. Bu hastaların 25inde  34.7 pankreatik fistül gözlemlendi. Bu çalışmada, BMI ve yumuşak pankreatik doku pankreatik fistül gelişimi için istatistiksel olarak anlamlı risk faktörleri olarak bulundu her ikisi için p0.02. Postoperatif üçün-cü günde ölçülen SII ve NLR, pankreatik fistül gelişiminin istatistiksel olarak anlamlı prediktörleri olurken, postoperatif PLRnin pankreatik fistül gelişimini tahmin etmede istatiksel anlamlı sonuç vermediği görüldü. SIInin pankreatik fistül gelişiminin tahmin edilmesinde NLRden daha güçlü bir prediktör olduğu görüldü. Sonuç: Bu çalışma, inflamasyonla ilişkili indeksler olan SII ve NLRdeki artışın, distal pankreatektomi sonrası pankreatik fistül gelişiminin tahmin edilmesinde etkili bir yöntem olduğunu göstermektedir. Buna karşılık, PLRnin pankreatik fistül gelişimini tahmin etmede etkili olmadığı görüldü.

Makale detayları

The Role of Inflammatory Indices in Predicting Pancreatic Fistula After Distal Pancreatectomy

Yazarlar:

Gökay Çetinkaya | Ahmet Cihangir Emral | Mustafa Kerem

Yayıncı:

Harran University

Ana Başlıklar:

Genel Cerrahi

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 2, pp.255-259

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343950

pISSN:

1304-9623

distal pancreatectomy

pancreatic fistula

SII

NLR

PLRdistal pankreatektomi

pankreatik fistül

SII

NLR

PLR

Sayı

Makale detayları

Yazarlar: Gökay Çetinkaya | Ahmet Cihangir Emral | Mustafa Kerem

Yayıncı: Harran University

Ana Başlıklar: Genel Cerrahi

Dergi: Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 2, pp.255-259

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001343950

pISSN: 1304-9623

Sayı

Yazarlar:

Gökay Çetinkaya | Ahmet Cihangir Emral | Mustafa Kerem

Yayıncı:

Harran University

Ana Başlıklar:

Genel Cerrahi

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 2, pp.255-259

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343950

pISSN:

1304-9623