The Effects of Potassium Bromate and Resveratrol on Fatty Acid Levels in Heart, Muscle and Brain of Wistar Rats

Serhat KESER; Okkes YILMAZ; Mehmet TUZCU

Makale detayları

The Effects of Potassium Bromate and Resveratrol on Fatty Acid Levels in Heart, Muscle and Brain of Wistar Rats

Yazarlar:

Serhat KESER | Okkes YILMAZ | Mehmet TUZCU

Yayıncı:

Gazi University

Dergi:

Gazi University Journal of Science 2011 Vol.24 Issue 2, pp.181-186

Belge Tipi:

Makale

Yayın Tarihi:

4/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000429614

eISSN:

2147-1762

Özet:

 


The aim of this study was to examine the effects of antioxidant resveratrol and carcinogen KBrO3 on the level of fatty acids in heart, muscle and brain of old female Wistar rats. In this study Wistar rats were randomly divided into three groups: 1. Control (C), 2. KBrO3 (P) (80 mg/kg, i.p. single dose) 3. Resveratrol+KBrO3 (Res) (80 mg/kg KBrO3 i.p. single dose, 33 mg/kg resveratrol, every other day, for 35 days). In heart, muscle and brain, fatty acid levels were measured by gas chromatography.

 

In the present study, palmitoleic acid (16:1) and oleic acid (18:1) levels were significantly increased in the P and Res groups (p<0.05, p<0.001, respectively). Stearic acid (18:0) and docosahexaenoic acid (22:6) levels were significantly decreased in the P and Res groups (p<0.01, p<0.05, respectively) in the heart. Palmitoleic acid (16:1), oleic acid (18:1) and linolenic acid (18:3) levels were significantly increased in the P and Res groups (p<0.01, p<0.001, p<0.05, respectively). Docosahexaenoic acid (22:6) level was decreased in the P and Res groups (p<0.05) in the muscle. Palmitoleic acid (16:1) and stearic acid (18:0) levels were decreased in the Res group (p<0.05) in the brain. Our results confirm that resveratrol and KBrO3 treatment were affected the amount of important fatty acids which substrates in fatty acids metabolism of heart, muscle and brain of Wistar rats.

 

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Makale detayları

The Effects of Potassium Bromate and Resveratrol on Fatty Acid Levels in Heart, Muscle and Brain of Wistar Rats

Yazarlar: Serhat KESER | Okkes YILMAZ | Mehmet TUZCU

Yayıncı: Gazi University

Dergi: Gazi University Journal of Science 2011 Vol.24 Issue 2, pp.181-186

Belge Tipi: Makale

Yayın Tarihi: 4/2011

Belge Dili: İngilizce

Document ID (Org No.): 2000429614

eISSN: 2147-1762

Sayı

Yazarlar:

Serhat KESER | Okkes YILMAZ | Mehmet TUZCU

Yayıncı:

Gazi University

Dergi:

Gazi University Journal of Science 2011 Vol.24 Issue 2, pp.181-186

Belge Tipi:

Makale

Yayın Tarihi:

4/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000429614

eISSN:

2147-1762