Risk factors for community-onset urinary tract infections caused by extended-spectrum ß-lactamase-producing Escherichia coli

Türkan TÜZÜN; Selda Sayin KUTLU; Murat KUTLU; İlknur KALELİ

Makale detayları

Risk factors for community-onset urinary tract infections caused by extended-spectrum ß-lactamase-producing Escherichia coli

Yazarlar:

Türkan TÜZÜN | Selda Sayin KUTLU | Murat KUTLU | İlknur KALELİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1206-1211

Belge Tipi:

Makale

Yayın Tarihi:

7/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000750038

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Community-onset  urinary  tract  infections(UTIs)  caused  by  extended-spectrum  ß-lactamase  (ESBL)-producing  Escherichia coli have increased in many parts of the world. This study aimed to determine the prevalence and risk factors for community-onset UTI caused by ESBL-producing E. coli.Materials and methods: This prospective cohort study was conducted between January 2012 and March 2014 in cases of community-onset UTI caused by E. coli. Patients with UTI due to ESBL-producing E. coli and patients with UTI due to non-ESBL-producing E. coliwere compared to identify risk factors for ESBL-producing E. coli in the community.Results: A total of 305 patients (116 males [46.4%]; mean age: 57.76 ± 18.06 years) were included in the study. Among these patients, 154 (50.5%) were infected with ESBL-producing E. coli. In multivariate analysis, the healthcare-associated UTI (odds ratio [OR]: 1.80; 95% confidence interval [CI]: 1.02?3.18; P = 0.041), upper urinary tract infection (OR: 3.05; 95% CI: 1.76?5.29; P < 0.0001), use of antibiotics in the preceding 6 months (OR: 2.28; 95% CI: 1.21?4.30; P = 0.011), and having two or more risk factors (OR: 4.03; 95% CI: 1.73?9.35; P = 0.001) were the significant factors associated with increased risk of community-onset UTIs due to ESBL-producing E. coli. Conclusion: The increasing prevalence ofESBL-producing E. coli makes it difficult to decide the empirical therapy in UTIs, especially in patients with two or more of the risk factors. A better understanding of the epidemiology and risk factors associated with community-onset UTIs due to ESBL-producing E. coli may have significant implications in decision-making for empirical antimicrobial treatment.

Makale detayları

Risk factors for community-onset urinary tract infections caused by extended-spectrum ß-lactamase-producing Escherichia coli

Yazarlar: Türkan TÜZÜN | Selda Sayin KUTLU | Murat KUTLU | İlknur KALELİ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1206-1211

Belge Tipi: Makale

Yayın Tarihi: 7/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000750038

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Türkan TÜZÜN | Selda Sayin KUTLU | Murat KUTLU | İlknur KALELİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1206-1211

Belge Tipi:

Makale

Yayın Tarihi:

7/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000750038

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144