The effect of levosimendan on Tp-e interval, Tp-e/QT ratio, Tp-e/QTc ratio and QRS interval in heart failure patients

Ibrahim Aktas; Alper Karakus; Sencer Camci; Hasan Ari; Selma Ari; Ahmet Tutuncu; Mehmet MELEK; Tahsin BOZAT

doi:https://doi.org/10.18621/eurj.278899

Makale detayları

The effect of levosimendan on Tp-e interval, Tp-e/QT ratio, Tp-e/QTc ratio and QRS interval in heart failure patients

Yazarlar:

Ibrahim Aktas | Alper Karakus | Sencer Camci | Hasan Ari | Selma Ari | Ahmet Tutuncu | Mehmet MELEK | Tahsin BOZAT

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2017 Vol.3 Issue 3, pp.220-226

Belge Tipi:

Makale

Yayın Tarihi:

11/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000663326

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.278899

Özet:

 


Increased Tp-e interval (from the peak-to-the-end of the
electrocardiographic T wave) and Tp-e/QT ratio are associated with malignant
ventricular arrhythmias. We aimed to evaluate the acute effects of levosimendan
on Tp-e interval, Tp-e/QT ratio, Tp-e/QTc ratio and QRS interval in patients
with severe heart failure. Methods. The study included 85
patients with decompansed heart failure, who were treated with levosimendan in
our cardiology department. We evaluated the patients retrospectively. QT and
Tp-e interval were assessed in the precordial leads. QRS duration was
determined in the single lead which had the longest QRS. Electrocardiographic
measurements was performed the basal (just before the levosimendan) and 24th
hour after the levosimendan infusion (just after the levosimendan infusion). Results.
No significant differences were found between before and after treatment of
levosimendan with respect to Tp-e and QTc interval, QRS duration, Tp-e/QT and
Tp-e/QTc ratio (pretreatment versus 24th hour values; p>0.05). Subgroup analysis was performed
in the patients with inotropic therapy including dopamine and/or dobutamin (34
patients) and without inotropic therapy (49 patients) during the levosimendan
infusion. The analysis showed that pretreatment and 24th hour values
of Tp-e interval and Tp-e/QT ratio were significantly higher in the inotropic
therapy group; (Pretreatment; Tp-e: 100.12±22.96 milliseconds [ms] versus
89.59±17.67 ms; p=0.03, Tp-e/QT: 0.26±0.05
versus 0.23±0.04; p=0.007, 24th
hour: Tp-e: 101.41±27.09 ms versus 88.77±15.89 ms; p=0.009, Tp-e/QT: 0.26±0.07 versus 0.23±0.05; p=0.03). However intra-group changes of these parameters, before
and after levosimendan treatment, were not significant (p>0.05). Conclusion. Our results suggested
that, therapeutic doses of levosimendan infusion don’t have a significant
effect on Tp-e and Tp-e/QT parameters. However inotropic therapy significantly
increases these parameters. 




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Makale detayları

The effect of levosimendan on Tp-e interval, Tp-e/QT ratio, Tp-e/QTc ratio and QRS interval in heart failure patients

Yazarlar: Ibrahim Aktas | Alper Karakus | Sencer Camci | Hasan Ari | Selma Ari | Ahmet Tutuncu | Mehmet MELEK | Tahsin BOZAT

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Sağlık teşvikleri

Dergi: The European Research Journal 2017 Vol.3 Issue 3, pp.220-226

Belge Tipi: Makale

Yayın Tarihi: 11/2017

Belge Dili: İngilizce

Document ID (Org No.): 2000663326

Sıklık: İki Aylık

eISSN: 2149-3189

DOI: https://doi.org/10.18621/eurj.278899

Sayı

Yazarlar:

Ibrahim Aktas | Alper Karakus | Sencer Camci | Hasan Ari | Selma Ari | Ahmet Tutuncu | Mehmet MELEK | Tahsin BOZAT

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2017 Vol.3 Issue 3, pp.220-226

Belge Tipi:

Makale

Yayın Tarihi:

11/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000663326

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.278899