Analysis of the Association of Allergic Disease in Pediatric Patients with Hereditary Angioedema

Ayşe Aydoğdu

Makale detayları

Analysis of the Association of Allergic Disease in Pediatric Patients with Hereditary Angioedema

Yazarlar:

Ayşe Aydoğdu

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Osmangazi Tıp Dergisi Vol.45 Issue 3, pp.321-325

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289308

pISSN:

1305-4953

Anahtar kelimeler:

Özet:

 Hereditary angioedema HAE is a rare autosomal dominant disease that is derived from the deficiency or dysfunction of C1 esterase inhibitor C1-INH. In studies about the diseases that can accompany hereditary angioedema, allergic diseases occur more frequently compared to the healthy population but no studies on this issue have been carried out. This study was conducted in order to determine the frequency of the comorbidity of atopic sensitivity and allergic diseases in patients with hereditary angioedema. 32 patients who were diagnosed with hereditary angioedema in the Paediatric Allergy Polyclinic of Mersin City Hospital between 2019 and 2021 were included in the study. In these patients, the information about the existence of atopic diseases was obtained from their files and recorded. While asthma was observed in 6 18.8, allergic rhinitis in 18 46.9, and urticaria in 2 6.2 patients, dermatitis was not observed in any of the patients. While Fx5 test was positive in 5 15.6 patients, inhalant allergen mix sps IgE was positive in 7 25.9 patients. The IgE value was above 100 in 12 52.2 patients, and the eosinophil level was above 4 in 16 50 patients. In conclusion, we speculate in this study that the association of atopic disease and atopic sensitivity is observed more frequently in patients with angioedema than in the healthy population. However, a study with a larger sample is necessary to confirm this finding.

 Hereditary angioedema HAE is a rare autosomal dominant disease that is derived from the deficiency or dysfunction of C1 esterase inhibitor C1-INH. In studies about the diseases that can accompany hereditary angioedema, allergic diseases occur more frequently compared to the healthy population but no studies on this issue have been carried out. This study was conducted in order to determine the frequency of the comorbidity of atopic sensitivity and allergic diseases in patients with hereditary angioedema. 32 patients who were diagnosed with hereditary angioedema in the Paediatric Allergy Polyclinic of Mersin City Hospital between 2019 and 2021 were included in the study. In these patients, the information about the existence of atopic diseases was obtained from their files and recorded. While asthma was observed in 6 18.8, allergic rhinitis in 18 46.9, and urticaria in 2 6.2 patients, dermatitis was not observed in any of the patients. While Fx5 test was positive in 5 15.6 patients, inhalant allergen mix sps IgE was positive in 7 25.9 patients. The IgE value was above 100 in 12 52.2 patients, and the eosinophil level was above 4 in 16 50 patients. In conclusion, we speculate in this study that the association of atopic disease and atopic sensitivity is observed more frequently in patients with angioedema than in the healthy population. However, a study with a larger sample is necessary to confirm this finding.

 Hereditary angioedema HAE is a rare autosomal dominant disease that is derived from the deficiency or dysfunction of C1 esterase inhibitor C1-INH. In studies about the diseases that can accompany hereditary angioedema, allergic diseases occur more frequently compared to the healthy population but no studies on this issue have been carried out. This study was conducted in order to determine the frequency of the comorbidity of atopic sensitivity and allergic diseases in patients with hereditary angioedema. 32 patients who were diagnosed with hereditary angioedema in the Paediatric Allergy Polyclinic of Mersin City Hospital between 2019 and 2021 were included in the study. In these patients, the information about the existence of atopic diseases was obtained from their files and recorded. While asthma was observed in 6 18.8, allergic rhinitis in 18 46.9, and urticaria in 2 6.2 patients, dermatitis was not observed in any of the patients. While Fx5 test was positive in 5 15.6 patients, inhalant allergen mix sps IgE was positive in 7 25.9 patients. The IgE value was above 100 in 12 52.2 patients, and the eosinophil level was above 4 in 16 50 patients. In conclusion, we speculate in this study that the association of atopic disease and atopic sensitivity is observed more frequently in patients with angioedema than in the healthy population. However, a study with a larger sample is necessary to confirm this finding.

 Hereditary angioedema HAE is a rare autosomal dominant disease that is derived from the deficiency or dysfunction of C1 esterase inhibitor C1-INH. In studies about the diseases that can accompany hereditary angioedema, allergic diseases occur more frequently compared to the healthy population but no studies on this issue have been carried out. This study was conducted in order to determine the frequency of the comorbidity of atopic sensitivity and allergic diseases in patients with hereditary angioedema. 32 patients who were diagnosed with hereditary angioedema in the Paediatric Allergy Polyclinic of Mersin City Hospital between 2019 and 2021 were included in the study. In these patients, the information about the existence of atopic diseases was obtained from their files and recorded. While asthma was observed in 6 18.8, allergic rhinitis in 18 46.9, and urticaria in 2 6.2 patients, dermatitis was not observed in any of the patients. While Fx5 test was positive in 5 15.6 patients, inhalant allergen mix sps IgE was positive in 7 25.9 patients. The IgE value was above 100 in 12 52.2 patients, and the eosinophil level was above 4 in 16 50 patients. In conclusion, we speculate in this study that the association of atopic disease and atopic sensitivity is observed more frequently in patients with angioedema than in the healthy population. However, a study with a larger sample is necessary to confirm this finding.

Makale detayları

Analysis of the Association of Allergic Disease in Pediatric Patients with Hereditary Angioedema

Yazarlar:

Ayşe Aydoğdu

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Osmangazi Tıp Dergisi Vol.45 Issue 3, pp.321-325

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289308

pISSN:

1305-4953

Allergy

Bradykinin

Hereditary angioedema,Hereditary angioedema

allergic inflammation

bradykinin

Allergy

Bradykinin

Sayı

Makale detayları

Yazarlar: Ayşe Aydoğdu

Yayıncı: Eskişehir Osmangazi University

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Osmangazi Tıp Dergisi Vol.45 Issue 3, pp.321-325

Belge Tipi: Makale

Yayın Tarihi: 5/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001289308

pISSN: 1305-4953

Sayı

Yazarlar:

Ayşe Aydoğdu

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Osmangazi Tıp Dergisi Vol.45 Issue 3, pp.321-325

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289308

pISSN:

1305-4953