The performance of various serum parameters in blood during the first trimester in the early detection of pre-eclampsia

Büşra Demir Çendek; Tuğba Ağbal; Arife Akay; Müjde Can İbanoğlu; Yaprak Engin Üstün

Makale detayları

The performance of various serum parameters in blood during the first trimester in the early detection of pre-eclampsia

Yazarlar:

Büşra Demir Çendek | Tuğba Ağbal | Arife Akay | Müjde Can İbanoğlu | Yaprak Engin Üstün

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kadın Hastalıkları ve Doğum

Dergi:

Journal of Health Sciences and Medicine Vol.7 Issue 4, pp.451-458

Belge Tipi:

Makale

Yayın Tarihi:

7/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001324273

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aims: The aim of this study is to examine the alterations in various serum parameters within the circulatory system throughout the first trimester and assess their efficacy in identifying pre-eclampsia at an early stage. Methods: This retrospective analysis undertook an examination of the medical records pertaining to 225 pregnancies that met the eligibility criteria at a tertiary referral center, spanning the years 2018 to 2021. Furthermore, an examination of laboratory parameters during the first trimester was performed, which included neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio PLR, monocyte-to-lymphocyte ratio MLR, systemic immune inflammation index, systemic inflammation response index, pan-immune inflammation value, AST-to-platelet ratio index, delta neutrophil index, and prognostic nutritional index PNI. A receiver operating characteristic curve analysis was performed to determine the optimal cut-off values for inflammatory and nutritional biomarkers to predict early- onset pre-eclampsia. Results: The group of individuals with early-onset pre-eclampsia displayed notably elevated levels of neutrophil, lymphocyte, PCT, MPV, ALT, and creatinine, while displaying significantly reduced levels of albumin, bilirubin, PLR, MLR, and PNI p0.05, for all. The statistical significance of the area under the curve for PNI, albumin, PLR, MLR, and bilirubin values was observed to be greater than 0.5 p0.05, for all. Conclusion: This article is the first to examine the efficacy of the first trimester PNI value in early detection of pre-eclampsia patients. According to this study, PNI, albumin, PLR, MLR, and bilirubin show potential as useful indicators for predicting the likelihood of developing pre-eclampsia at an early stage in the first trimester.

 Aims: The aim of this study is to examine the alterations in various serum parameters within the circulatory system throughout the first trimester and assess their efficacy in identifying pre-eclampsia at an early stage. Methods: This retrospective analysis undertook an examination of the medical records pertaining to 225 pregnancies that met the eligibility criteria at a tertiary referral center, spanning the years 2018 to 2021. Furthermore, an examination of laboratory parameters during the first trimester was performed, which included neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio PLR, monocyte-to-lymphocyte ratio MLR, systemic immune inflammation index, systemic inflammation response index, pan-immune inflammation value, AST-to-platelet ratio index, delta neutrophil index, and prognostic nutritional index PNI. A receiver operating characteristic curve analysis was performed to determine the optimal cut-off values for inflammatory and nutritional biomarkers to predict early- onset pre-eclampsia. Results: The group of individuals with early-onset pre-eclampsia displayed notably elevated levels of neutrophil, lymphocyte, PCT, MPV, ALT, and creatinine, while displaying significantly reduced levels of albumin, bilirubin, PLR, MLR, and PNI p0.05, for all. The statistical significance of the area under the curve for PNI, albumin, PLR, MLR, and bilirubin values was observed to be greater than 0.5 p0.05, for all. Conclusion: This article is the first to examine the efficacy of the first trimester PNI value in early detection of pre-eclampsia patients. According to this study, PNI, albumin, PLR, MLR, and bilirubin show potential as useful indicators for predicting the likelihood of developing pre-eclampsia at an early stage in the first trimester.

 Aims: The aim of this study is to examine the alterations in various serum parameters within the circulatory system throughout the first trimester and assess their efficacy in identifying pre-eclampsia at an early stage. Methods: This retrospective analysis undertook an examination of the medical records pertaining to 225 pregnancies that met the eligibility criteria at a tertiary referral center, spanning the years 2018 to 2021. Furthermore, an examination of laboratory parameters during the first trimester was performed, which included neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio PLR, monocyte-to-lymphocyte ratio MLR, systemic immune inflammation index, systemic inflammation response index, pan-immune inflammation value, AST-to-platelet ratio index, delta neutrophil index, and prognostic nutritional index PNI. A receiver operating characteristic curve analysis was performed to determine the optimal cut-off values for inflammatory and nutritional biomarkers to predict early- onset pre-eclampsia. Results: The group of individuals with early-onset pre-eclampsia displayed notably elevated levels of neutrophil, lymphocyte, PCT, MPV, ALT, and creatinine, while displaying significantly reduced levels of albumin, bilirubin, PLR, MLR, and PNI p0.05, for all. The statistical significance of the area under the curve for PNI, albumin, PLR, MLR, and bilirubin values was observed to be greater than 0.5 p0.05, for all. Conclusion: This article is the first to examine the efficacy of the first trimester PNI value in early detection of pre-eclampsia patients. According to this study, PNI, albumin, PLR, MLR, and bilirubin show potential as useful indicators for predicting the likelihood of developing pre-eclampsia at an early stage in the first trimester.

 Aims: The aim of this study is to examine the alterations in various serum parameters within the circulatory system throughout the first trimester and assess their efficacy in identifying pre-eclampsia at an early stage. Methods: This retrospective analysis undertook an examination of the medical records pertaining to 225 pregnancies that met the eligibility criteria at a tertiary referral center, spanning the years 2018 to 2021. Furthermore, an examination of laboratory parameters during the first trimester was performed, which included neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio PLR, monocyte-to-lymphocyte ratio MLR, systemic immune inflammation index, systemic inflammation response index, pan-immune inflammation value, AST-to-platelet ratio index, delta neutrophil index, and prognostic nutritional index PNI. A receiver operating characteristic curve analysis was performed to determine the optimal cut-off values for inflammatory and nutritional biomarkers to predict early- onset pre-eclampsia. Results: The group of individuals with early-onset pre-eclampsia displayed notably elevated levels of neutrophil, lymphocyte, PCT, MPV, ALT, and creatinine, while displaying significantly reduced levels of albumin, bilirubin, PLR, MLR, and PNI p0.05, for all. The statistical significance of the area under the curve for PNI, albumin, PLR, MLR, and bilirubin values was observed to be greater than 0.5 p0.05, for all. Conclusion: This article is the first to examine the efficacy of the first trimester PNI value in early detection of pre-eclampsia patients. According to this study, PNI, albumin, PLR, MLR, and bilirubin show potential as useful indicators for predicting the likelihood of developing pre-eclampsia at an early stage in the first trimester.

Makale detayları

The performance of various serum parameters in blood during the first trimester in the early detection of pre-eclampsia

Yazarlar:

Büşra Demir Çendek | Tuğba Ağbal | Arife Akay | Müjde Can İbanoğlu | Yaprak Engin Üstün

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kadın Hastalıkları ve Doğum

Dergi:

Journal of Health Sciences and Medicine Vol.7 Issue 4, pp.451-458

Belge Tipi:

Makale

Yayın Tarihi:

7/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001324273

pISSN:

2636-8579

Serum markers

pregnancy

first trimester

high-risk

pre-eclampsia

Sayı

Makale detayları

The performance of various serum parameters in blood during the first trimester in the early detection of pre-eclampsia

Yazarlar: Büşra Demir Çendek | Tuğba Ağbal | Arife Akay | Müjde Can İbanoğlu | Yaprak Engin Üstün

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Kadın Hastalıkları ve Doğum

Dergi: Journal of Health Sciences and Medicine Vol.7 Issue 4, pp.451-458

Belge Tipi: Makale

Yayın Tarihi: 7/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001324273

pISSN: 2636-8579

Serum markers

pregnancy

first trimester

high-risk

pre-eclampsia

Sayı

Yazarlar:

Büşra Demir Çendek | Tuğba Ağbal | Arife Akay | Müjde Can İbanoğlu | Yaprak Engin Üstün

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kadın Hastalıkları ve Doğum

Dergi:

Journal of Health Sciences and Medicine Vol.7 Issue 4, pp.451-458

Belge Tipi:

Makale

Yayın Tarihi:

7/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001324273

pISSN:

2636-8579