The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women

Özlem ŞENGÜL; Dilek UYGUR; Mustafa GÜLEÇ; Berna DİLBAZ; Esma Meltem ŞİMŞEK; Ümit GÖKTOLGA

Makale detayları

The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women

Yazarlar:

Özlem ŞENGÜL | Dilek UYGUR | Mustafa GÜLEÇ | Berna DİLBAZ | Esma Meltem ŞİMŞEK | Ümit GÖKTOLGA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 4, pp.611-615

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000753162

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

To investigate if there is any association between the serum folate and vitamin B12 status and the depressive symptoms in postmenopausal women.   Materials and methods: The study included 95 postmenopausal women. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess their depressive symptoms. The investigated women were classified into 2 groups based on the existence of depressive symptoms. These 2 groups were compared in terms of folic acid and vitamin B12 levels.    Results: Among 95 cases, 27 postmenopausal women scored 16 or more on the CES-D scale and were classified as the depressive group (Group 1), and 68 postmenopausal women scored 15 or less and were classified as the nondepressive group (Group 2). The serum levels of folate were 11.5 ± 5.4 ng/mL in group 1 and 12.3 ± 5.3 ng/mL in group 2. The concentrations of vitamin B12 were 456.2 ± 343.4 pg/mL in group 1 and 446.5 ± 165.1 pg/mL in group 2. The folate and vitamin B12 levels did not significantly correlate to the frequency of depressive symptoms (P = 0.52 and P = 0.24, respectively).   Conclusion: In this study, no correlation was detected between serum folate and vitamin B12 levels and depressive symptoms in postmenopausal women. Supplementation of folic acid and vitamin B12 for postmenopausal women does not seem to be an effective intervention to reduce depressive symptoms.

 

To investigate if there is any association between the serum folate and vitamin B12 status and the depressive symptoms in postmenopausal women.   Materials and methods: The study included 95 postmenopausal women. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess their depressive symptoms. The investigated women were classified into 2 groups based on the existence of depressive symptoms. These 2 groups were compared in terms of folic acid and vitamin B12 levels.    Results: Among 95 cases, 27 postmenopausal women scored 16 or more on the CES-D scale and were classified as the depressive group (Group 1), and 68 postmenopausal women scored 15 or less and were classified as the nondepressive group (Group 2). The serum levels of folate were 11.5 ± 5.4 ng/mL in group 1 and 12.3 ± 5.3 ng/mL in group 2. The concentrations of vitamin B12 were 456.2 ± 343.4 pg/mL in group 1 and 446.5 ± 165.1 pg/mL in group 2. The folate and vitamin B12 levels did not significantly correlate to the frequency of depressive symptoms (P = 0.52 and P = 0.24, respectively).   Conclusion: In this study, no correlation was detected between serum folate and vitamin B12 levels and depressive symptoms in postmenopausal women. Supplementation of folic acid and vitamin B12 for postmenopausal women does not seem to be an effective intervention to reduce depressive symptoms.

Makale detayları

The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women

Yazarlar:

Özlem ŞENGÜL | Dilek UYGUR | Mustafa GÜLEÇ | Berna DİLBAZ | Esma Meltem ŞİMŞEK | Ümit GÖKTOLGA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 4, pp.611-615

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000753162

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Depressive symptoms

folate

menopause

vitamin B12

Sayı

Makale detayları

The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women

Yazarlar: Özlem ŞENGÜL | Dilek UYGUR | Mustafa GÜLEÇ | Berna DİLBAZ | Esma Meltem ŞİMŞEK | Ümit GÖKTOLGA

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2014 Vol.44 Issue 4, pp.611-615

Belge Tipi: Makale

Yayın Tarihi: 5/2014

Belge Dili: Türkçe

Document ID (Org No.): 2000753162

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Depressive symptoms

folate

menopause

vitamin B12

Sayı

Yazarlar:

Özlem ŞENGÜL | Dilek UYGUR | Mustafa GÜLEÇ | Berna DİLBAZ | Esma Meltem ŞİMŞEK | Ümit GÖKTOLGA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 4, pp.611-615

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000753162

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144