Development of Nephelometric Α1-At Method and its Performance Characteristics

M. ÇALAPOĞLU; O. DEĞER; A. ALVER; N. Ş. ÇALAPOĞLU; E. KALAY; C. K. BURUK

Makale detayları

Development of Nephelometric Α1-At Method and its Performance Characteristics

Yazarlar:

M. ÇALAPOĞLU | O. DEĞER | A. ALVER | N. Ş. ÇALAPOĞLU | E. KALAY | C. K. BURUK

Yayıncı:

Kyrgyz-Turkish Manas University

Dergi:

Manas Journal of Natural Sciences 2005 Vol.1 Issue 6, pp.29-39

Belge Tipi:

Makale

Yayın Tarihi:

12/2004

Belge Dili:

İngilizce

Document ID (Org No.):

2000528515

Sıklık:

İki Yıllık

eISSN:

1694-7398

pISSN:

1694-7398

Özet:

 

α1-AT, a glycoprotein of molecular mass of 52 kDa, is a major plasma serine  protease inhibitor  serpin . α1-AT plays a central role as a protease inhibitor in controlling  tissue degradation. As a major protease inhibitor in human plasma, α1-AT can complex  with a broad spectrum of proteases including elastase, trypsin, chymotrypsin, thrombin,  and bacterial leukocyte elastase. α1-AT is an acute phase reactant whose plasma  concentration can rise by 3 to 4-fold above normal during inflammation, infection and  malignant disease. α1-AT deficiency, one of the most common hereditary disorders,  mainly affects the liver and lung [1,2]. The concentrations of α1-AT in plasma can be  measured either by functional assays or by immunochemical methods. Functional assays  evaluate inhibition of trypsin or elastase. Immunologic methods include radial  immunodiffusion, electroimmunoassay and automated nephelometric methods.

Makale detayları

Development of Nephelometric Α1-At Method and its Performance Characteristics

Yazarlar: M. ÇALAPOĞLU | O. DEĞER | A. ALVER | N. Ş. ÇALAPOĞLU | E. KALAY | C. K. BURUK

Yayıncı: Kyrgyz-Turkish Manas University

Dergi: Manas Journal of Natural Sciences 2005 Vol.1 Issue 6, pp.29-39

Belge Tipi: Makale

Yayın Tarihi: 12/2004

Belge Dili: İngilizce

Document ID (Org No.): 2000528515

Sıklık: İki Yıllık

eISSN: 1694-7398

pISSN: 1694-7398

Sayı

Yazarlar:

M. ÇALAPOĞLU | O. DEĞER | A. ALVER | N. Ş. ÇALAPOĞLU | E. KALAY | C. K. BURUK

Yayıncı:

Kyrgyz-Turkish Manas University

Dergi:

Manas Journal of Natural Sciences 2005 Vol.1 Issue 6, pp.29-39

Belge Tipi:

Makale

Yayın Tarihi:

12/2004

Belge Dili:

İngilizce

Document ID (Org No.):

2000528515

Sıklık:

İki Yıllık

eISSN:

1694-7398

pISSN:

1694-7398