Potential drug-drug interactions among prescriptions  for elderly patients in primary health care

Zafer GÖREN; Mahluga J. DEMIRKAPU; Gökçe Akpinar ACET; SANDA ÇALI; Medine Gülçebi İdriz OĞLU

Makale detayları

Potential drug-drug interactions among prescriptions for elderly patients in primary health care

Yazarlar:

Zafer GÖREN | Mahluga J. DEMIRKAPU | Gökçe Akpinar ACET | SANDA ÇALI | Medine Gülçebi İdriz OĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.47-54

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751525

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Elderly patients are at high risk from drug-drug interactions (DDIs). This study evaluates the potential DDIs in Turkish elderly patients at a primary health care outpatient clinic.  Materials and methods: Online database systems were used to examine DDIs on the prescriptions of patients (n = 1206). The clinical severity of DDIs was classified by the Lexi-Interact Online database.   Results: Of the 5059 prescriptions, 33% were found to have DDIs. We detected 29 (0.9%) A, 380 (11.8%) B, 2494 (77.7%) C, 289 (9%) D, and 18 (0.6%) X risk rating category DDIs among the prescriptions. Prescriptions of female patients and patients aged between 65 and 72 years showed significantly higher number of DDIs. The frequency of DDIs increased both with the number of drugs and combined preparations per prescription. Acetylsalicylic acid and salbutamol were the most frequently prescribed drugs contributing to clinically important DDIs. Additionally, acetylsalicylic acid and escitalopram, which interact with each other, were found on the list of Beers criteria. The most predicted clinical outcomes of DDIs were increase in therapeutic efficacy and adverse/toxic reactions.   Conclusions: Prediction of DDIs in elderly patients will provide better prescribing and drug safety. Use of nonsteroidal anti-inflammatory agents, selective serotonin reuptake inhibitors, and beta-2 adrenergic receptor agonists should be closely monitored.

Makale detayları

Potential drug-drug interactions among prescriptions for elderly patients in primary health care

Yazarlar: Zafer GÖREN | Mahluga J. DEMIRKAPU | Gökçe Akpinar ACET | SANDA ÇALI | Medine Gülçebi İdriz OĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.47-54

Belge Tipi: Makale

Yayın Tarihi: 1/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000751525

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Zafer GÖREN | Mahluga J. DEMIRKAPU | Gökçe Akpinar ACET | SANDA ÇALI | Medine Gülçebi İdriz OĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.47-54

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751525

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144