THE INVESTIGATION OF THE INTERACTION OF SEVERAL  ANTIPSYCHOTIC DRUGS WITH HUMAN CHOLINESTERASE ENZYMES

Sonia SANAJOU; Shalaleh NOURHASHEMİ; Amirhossein FALLAH; Tugba ERCETİN; Mustafa Fethi SAHİN; Hayrettin Ozan GULCAN

Makale detayları

THE INVESTIGATION OF THE INTERACTION OF SEVERAL ANTIPSYCHOTIC DRUGS WITH HUMAN CHOLINESTERASE ENZYMES

Yazarlar:

Sonia SANAJOU | Shalaleh NOURHASHEMİ | Amirhossein FALLAH | Tugba ERCETİN | Mustafa Fethi SAHİN | Hayrettin Ozan GULCAN

Yayıncı:

Dogu Akdeniz University

Dergi:

EMU Journal of Pharmaceutical Sciences 2018 Vol.1 Issue 1, pp.1-5

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000697751

Sıklık:

Üç Yıllık

pISSN:

2651-3587

Özet:

 

Phenothiazines and butyrophenones are one of the important antipsychotic group of drugs. They have    been utilized for many years for treatment of schizophrenia and other psychotic disorders. They are the    main constituents of the first generation, also referred as typical, antipsychotic drugs. They are known    for their potential to antagonize dopamine D2 receptors. With respect to their structures, they are able    to cross the blood brain barrier and interact with various types of receptors. In order to investigate their    potential to interact with cholinesterase enzymes, within this research, we have designed a series of    experiments. Although, earlier studies have shown that some of those compounds have the potential to    inhibit cholinesterase enzyme, for the first time, we have evaluated their potential to inhibit human    isoforms of acetylcholinesterase and butyrylcholinesterase. The results strongly pointed out that    phenothiazines are selective and potent inhibitors of the human butyrylcholinesterase enzyme.

Makale detayları

THE INVESTIGATION OF THE INTERACTION OF SEVERAL ANTIPSYCHOTIC DRUGS WITH HUMAN CHOLINESTERASE ENZYMES

Yazarlar: Sonia SANAJOU | Shalaleh NOURHASHEMİ | Amirhossein FALLAH | Tugba ERCETİN | Mustafa Fethi SAHİN | Hayrettin Ozan GULCAN

Yayıncı: Dogu Akdeniz University

Dergi: EMU Journal of Pharmaceutical Sciences 2018 Vol.1 Issue 1, pp.1-5

Belge Tipi: Makale

Yayın Tarihi: 5/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000697751

Sıklık: Üç Yıllık

pISSN: 2651-3587

Sayı

Yazarlar:

Sonia SANAJOU | Shalaleh NOURHASHEMİ | Amirhossein FALLAH | Tugba ERCETİN | Mustafa Fethi SAHİN | Hayrettin Ozan GULCAN

Yayıncı:

Dogu Akdeniz University

Dergi:

EMU Journal of Pharmaceutical Sciences 2018 Vol.1 Issue 1, pp.1-5

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000697751

Sıklık:

Üç Yıllık

pISSN:

2651-3587