Seroprevalence of Toxoplasma, Rubella, and Cytomegalovirus Infections in Women of Childbearing Age Admitted to Kafkas University Health Research and Application Hospital: A Three-Year Evaluation

Didem Özgür

Makale detayları

Seroprevalence of Toxoplasma, Rubella, and Cytomegalovirus Infections in Women of Childbearing Age Admitted to Kafkas University Health Research and Application Hospital: A Three-Year Evaluation

Yazarlar:

Didem Özgür

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Epidemiyoloji (Diğer)

Dergi:

Black Sea Journal of Health Science Vol.6 Issue 4, pp.719-725

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001290986

pISSN:

2619-9041

Anahtar kelimeler:

Özet:

 TORCH infections refer to a group of infections caused by pathogens such as Toxoplasma gondii, Rubella, Cytomegalovirus CMV, Herpes simplex virus, and others, which can cross the maternal-fetal barrier and potentially adversely affect fetal development. This study aims to determine the seroprevalence of antibodies against Toxoplasma, Rubella, and CMV in women of childbearing age who have the potential to cause congenital infections. The results of a total of 2155 women aged 15-49 years, who were sent to our laboratory for the investigation of anti-Toxoplasma IgM and IgG, anti-Rubella IgM and IgG, and anti-CMV IgM and IgG serology between January 1, 2020, and December 1, 2022, were retrospectively analyzed. IgM and IgG antibodies in patient sera were detected using the Enzyme Linked Fluorescent Assay ELFA-VIDAS, bioMérieux, France method. Our study results shows that the positivity rates of anti-Toxoplasma IgM and IgG were 0.5 and 19.4, respectively; anti-Rubella IgM and IgG were 0.5 and 92.3, respectively; and anti-CMV IgM and IgG were 0.5 and 99.9, respectively. A statistically significant difference was observed between age groups and Toxoplasma IgG seropositivity, with a statistically significant increase as age decreased P0.001. The high prevalence of CMV and Rubella IgG seropositivity in women of childbearing age in our region suggests that there may not be a need for screening in pregnant women for these factors. Additionally, considering the widespread practice of agriculture and livestock farming in our region, dietary habits involving a meat-based diet or undercooked meat consumption, and the relatively low rates of Toxoplasma seropositivity, we believe it would be appropriate for Toxoplasma to be included in the screening program.

 TORCH infections refer to a group of infections caused by pathogens such as Toxoplasma gondii, Rubella, Cytomegalovirus CMV, Herpes simplex virus, and others, which can cross the maternal-fetal barrier and potentially adversely affect fetal development. This study aims to determine the seroprevalence of antibodies against Toxoplasma, Rubella, and CMV in women of childbearing age who have the potential to cause congenital infections. The results of a total of 2155 women aged 15-49 years, who were sent to our laboratory for the investigation of anti-Toxoplasma IgM and IgG, anti-Rubella IgM and IgG, and anti-CMV IgM and IgG serology between January 1, 2020, and December 1, 2022, were retrospectively analyzed. IgM and IgG antibodies in patient sera were detected using the Enzyme Linked Fluorescent Assay ELFA-VIDAS, bioMérieux, France method. Our study results shows that the positivity rates of anti-Toxoplasma IgM and IgG were 0.5 and 19.4, respectively; anti-Rubella IgM and IgG were 0.5 and 92.3, respectively; and anti-CMV IgM and IgG were 0.5 and 99.9, respectively. A statistically significant difference was observed between age groups and Toxoplasma IgG seropositivity, with a statistically significant increase as age decreased P0.001. The high prevalence of CMV and Rubella IgG seropositivity in women of childbearing age in our region suggests that there may not be a need for screening in pregnant women for these factors. Additionally, considering the widespread practice of agriculture and livestock farming in our region, dietary habits involving a meat-based diet or undercooked meat consumption, and the relatively low rates of Toxoplasma seropositivity, we believe it would be appropriate for Toxoplasma to be included in the screening program.

 TORCH infections refer to a group of infections caused by pathogens such as Toxoplasma gondii, Rubella, Cytomegalovirus CMV, Herpes simplex virus, and others, which can cross the maternal-fetal barrier and potentially adversely affect fetal development. This study aims to determine the seroprevalence of antibodies against Toxoplasma, Rubella, and CMV in women of childbearing age who have the potential to cause congenital infections. The results of a total of 2155 women aged 15-49 years, who were sent to our laboratory for the investigation of anti-Toxoplasma IgM and IgG, anti-Rubella IgM and IgG, and anti-CMV IgM and IgG serology between January 1, 2020, and December 1, 2022, were retrospectively analyzed. IgM and IgG antibodies in patient sera were detected using the Enzyme Linked Fluorescent Assay ELFA-VIDAS, bioMérieux, France method. Our study results shows that the positivity rates of anti-Toxoplasma IgM and IgG were 0.5 and 19.4, respectively; anti-Rubella IgM and IgG were 0.5 and 92.3, respectively; and anti-CMV IgM and IgG were 0.5 and 99.9, respectively. A statistically significant difference was observed between age groups and Toxoplasma IgG seropositivity, with a statistically significant increase as age decreased P0.001. The high prevalence of CMV and Rubella IgG seropositivity in women of childbearing age in our region suggests that there may not be a need for screening in pregnant women for these factors. Additionally, considering the widespread practice of agriculture and livestock farming in our region, dietary habits involving a meat-based diet or undercooked meat consumption, and the relatively low rates of Toxoplasma seropositivity, we believe it would be appropriate for Toxoplasma to be included in the screening program.

 TORCH enfeksiyonları, Toxoplasma gondii, Rubella, Sitomegalovirus CMV, Herpes simpleks virüs ve diğer bazı patojenlerin neden olduğu, anne-fetal bariyeri geçebilen ve potansiyel olarak fetüsün gelişimini olumsuz etkileyebilen bir grup enfeksiyonu ifade etmektedir. Bu çalışmada, doğurganlık çağındaki kadınlarda konjenital enfeksiyonlara neden olma potansiyeline sahip Toksoplazma, Rubella ve CMVye karşı oluşan antikorların seroprevalansının belirlenmesi amaçlanmıştır. 1 Ocak 2020 ve 1 Aralık 2022 tarihleri arasında laboratuvarımıza anti-Toksoplazma IgM ve IgG, anti-Rubella IgM ve IgG, anti-CMV IgM ve IgG serolojisinin araştırılması amacı ile gönderilen doğurganlık çağındaki 1549 yaş arası toplam 2155 kadına ait test sonuçları retrospektif olarak incelenmiştir. Hasta serumlarında, IgM ve IgG antikorları Enzyme Linked Fluorescent Assay ELFA-VIDAS, bioMérieux, Fransa yöntemi ile tespit edilmiştir. Çalışmamızda anti-Toksoplazma IgM pozitifliği 0,5, anti-Toksoplazma IgG pozitifliği 19,4; anti-Rubella IgM pozitifliği 0,5, anti-Rubella IgG pozitifliği 92,3; anti-CMV IgM pozitifliği 0,5, anti-CMV IgG pozitifliği ise 99,9 olarak tespit edilmiştir. Toksoplazma IgG seropozitifliği ile yaş grubu arasında istatistiksel olarak anlamlı bir farklılık olduğu ve yaşın azalması ile istatistiksel olarak arttığı tespit edilmiştir p0,001. Bölgemizde doğurganlık çağındaki kadınlarda yüksek oranda CMV IgG ve rubella IgG seropozitifliği saptanması, bu etkene karşı gebelerde taramaya gerek olmadığını göstermektedir. Ayrıca, bölgemizde tarım ve hayvancılığın yaygın olması, et ağırlıklı veya az pişmiş etle beslenme alışkanlığı ve Toksoplazma seropozitiflik oranlarının düşük düzeyde olması nedeniyle, tarama programında yer almasının uygun olacağını düşünmekteyiz.

Makale detayları

Seroprevalence of Toxoplasma, Rubella, and Cytomegalovirus Infections in Women of Childbearing Age Admitted to Kafkas University Health Research and Application Hospital: A Three-Year Evaluation

Yazarlar:

Didem Özgür

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Epidemiyoloji (Diğer)

Dergi:

Black Sea Journal of Health Science Vol.6 Issue 4, pp.719-725

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001290986

pISSN:

2619-9041

TORCH

Toxoplasma gondii

Rubella

Cytomegalovirus

SeropositivityTORCH

Toxoplasma gondii

Rubella

Sitomegalovirus

Seropozitiflik

Sayı

Makale detayları

Yazarlar: Didem Özgür

Yayıncı: Karyay Karadeniz Yayımcılık

Ana Başlıklar: Epidemiyoloji (Diğer)

Dergi: Black Sea Journal of Health Science Vol.6 Issue 4, pp.719-725

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001290986

pISSN: 2619-9041

Sayı

Yazarlar:

Didem Özgür

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Epidemiyoloji (Diğer)

Dergi:

Black Sea Journal of Health Science Vol.6 Issue 4, pp.719-725

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001290986

pISSN:

2619-9041