Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives

Oya ÜNSAL TAN; Keriman ÖZADALI; Özgür YEŞİLYURT

Makale detayları

Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives

Yazarlar:

Oya ÜNSAL TAN | Keriman ÖZADALI | Özgür YEŞİLYURT

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2011 Vol.35 Issue 1, pp.121-130

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000727921

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Some isoxazolo[4,5-d]pyridazin4(5H)-one derivatives were  synthesized and tested for their analgesic activity.  The analgesic  activities of the compounds were determined by hot-plate and acetic  acid writhing tests using morphine and diclofenac as references.  Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles  similar to that of morphine (5 mg/kg).

 

Some isoxazolo[4,5-d]pyridazin4(5H)-one derivatives were  synthesized and tested for their analgesic activity.  The analgesic  activities of the compounds were determined by hot-plate and acetic  acid writhing tests using morphine and diclofenac as references.  Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles  similar to that of morphine (5 mg/kg).

Makale detayları

Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives

Yazarlar: Oya ÜNSAL TAN | Keriman ÖZADALI | Özgür YEŞİLYURT

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2011 Vol.35 Issue 1, pp.121-130

Belge Tipi: Makale

Yayın Tarihi: 12/2010

Belge Dili: Türkçe

Document ID (Org No.): 2000727921

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Oya ÜNSAL TAN | Keriman ÖZADALI | Özgür YEŞİLYURT

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2011 Vol.35 Issue 1, pp.121-130

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000727921

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527