Synthesis and antitubercular activities of acetamide-substituted benzazole derivatives

Şule Gürsoy; Elif Şevval Öztürk; Bayan Zoatier; Mahmut Ülger; Öztekin Algül

Makale detayları

Synthesis and antitubercular activities of acetamide-substituted benzazole derivatives

Yazarlar:

Şule Gürsoy | Elif Şevval Öztürk | Bayan Zoatier | Mahmut Ülger | Öztekin Algül

Yayıncı:

Erzincan Binali Yildirim University

Ana Başlıklar:

Farmasotik Kimya

Dergi:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.17 Issue 2, pp.474-487

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325579

pISSN:

2149-4584

Anahtar kelimeler:

Özet:

 Multidrug-resistant Mycobacterium tuberculosis strains increasing emergence and rapid spread necessitate the urgent development of innovative antimycobacterial agents. In pursuit of novel agents, a series of N-benzazole-2-ylmethyl-2-substituted phenylacetamide or N-benzazole-2-ylmethyl-2-thiophen-2-ylacetamide compounds 6-11 were synthesized. Their efficacy against multidrug-resistant Mycobacterium tuberculosis was assessed. Compounds exhibited potent antimycobacterial activity with minimum inhibitory concentrations MIC ranging from 1.05 to 4.10 µM and demonstrated low cytotoxicity towards fibroblast cell line L929. ADMET predictions suggested that these synthesized compounds possess drug-like properties. Our findings offer a promising starting point for designing more selective and potent antimycobacterial agents.

 Multidrug-resistant Mycobacterium tuberculosis strains increasing emergence and rapid spread necessitate the urgent development of innovative antimycobacterial agents. In pursuit of novel agents, a series of N-benzazole-2-ylmethyl-2-substituted phenylacetamide or N-benzazole-2-ylmethyl-2-thiophen-2-ylacetamide compounds 6-11 were synthesized. Their efficacy against multidrug-resistant Mycobacterium tuberculosis was assessed. Compounds exhibited potent antimycobacterial activity with minimum inhibitory concentrations MIC ranging from 1.05 to 4.10 µM and demonstrated low cytotoxicity towards fibroblast cell line L929. ADMET predictions suggested that these synthesized compounds possess drug-like properties. Our findings offer a promising starting point for designing more selective and potent antimycobacterial agents.

 Multidrug-resistant Mycobacterium tuberculosis strains increasing emergence and rapid spread necessitate the urgent development of innovative antimycobacterial agents. In pursuit of novel agents, a series of N-benzazole-2-ylmethyl-2-substituted phenylacetamide or N-benzazole-2-ylmethyl-2-thiophen-2-ylacetamide compounds 6-11 were synthesized. Their efficacy against multidrug-resistant Mycobacterium tuberculosis was assessed. Compounds exhibited potent antimycobacterial activity with minimum inhibitory concentrations MIC ranging from 1.05 to 4.10 µM and demonstrated low cytotoxicity towards fibroblast cell line L929. ADMET predictions suggested that these synthesized compounds possess drug-like properties. Our findings offer a promising starting point for designing more selective and potent antimycobacterial agents.

 Multidrug-resistant Mycobacterium tuberculosis strains increasing emergence and rapid spread necessitate the urgent development of innovative antimycobacterial agents. In pursuit of novel agents, a series of N-benzazole-2-ylmethyl-2-substituted phenylacetamide or N-benzazole-2-ylmethyl-2-thiophen-2-ylacetamide compounds 6-11 were synthesized. Their efficacy against multidrug-resistant Mycobacterium tuberculosis was assessed. Compounds exhibited potent antimycobacterial activity with minimum inhibitory concentrations MIC ranging from 1.05 to 4.10 µM and demonstrated low cytotoxicity towards fibroblast cell line L929. ADMET predictions suggested that these synthesized compounds possess drug-like properties. Our findings offer a promising starting point for designing more selective and potent antimycobacterial agents.

Makale detayları

Synthesis and antitubercular activities of acetamide-substituted benzazole derivatives

Yazarlar:

Şule Gürsoy | Elif Şevval Öztürk | Bayan Zoatier | Mahmut Ülger | Öztekin Algül

Yayıncı:

Erzincan Binali Yildirim University

Ana Başlıklar:

Farmasotik Kimya

Dergi:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.17 Issue 2, pp.474-487

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325579

pISSN:

2149-4584

Benzazole

synthesis

Mycobacterium tuberculosis

MIC

antitubercular activity

Sayı

Makale detayları

Synthesis and antitubercular activities of acetamide-substituted benzazole derivatives

Yazarlar: Şule Gürsoy | Elif Şevval Öztürk | Bayan Zoatier | Mahmut Ülger | Öztekin Algül

Yayıncı: Erzincan Binali Yildirim University

Ana Başlıklar: Farmasotik Kimya

Dergi: Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.17 Issue 2, pp.474-487

Belge Tipi: Makale

Yayın Tarihi: 8/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001325579

pISSN: 2149-4584

Benzazole

synthesis

Mycobacterium tuberculosis

MIC

antitubercular activity

Sayı

Yazarlar:

Şule Gürsoy | Elif Şevval Öztürk | Bayan Zoatier | Mahmut Ülger | Öztekin Algül

Yayıncı:

Erzincan Binali Yildirim University

Ana Başlıklar:

Farmasotik Kimya

Dergi:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.17 Issue 2, pp.474-487

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325579

pISSN:

2149-4584