Antibacterial and antioxidant activities of novel 2-ethoxy- 4-[(4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azomethine]- phenyl 3-methoxybenzoate derivatives

Özlem Gürsoy Kol; Sevda Manap; Murat Beytur; Fevzi Aytemiz; Muzaffer Alkan; Haydar Yüksek

Makale detayları

Antibacterial and antioxidant activities of novel 2-ethoxy- 4-[(4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azomethine]- phenyl 3-methoxybenzoate derivatives

Yazarlar:

Özlem Gürsoy Kol | Sevda Manap | Murat Beytur | Fevzi Aytemiz | Muzaffer Alkan | Haydar Yüksek

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 2, pp.692-704

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341715

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 In the present study, 3-alkylaryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 1 reacted with 3-ethoxy-4- 3-methoxybenzoxy-benzaldehyde 2 to obtain the corresponding nine new 2-ethoxy-4-3-alkylaryl-4,5-dihydro-1H- 1,2,4-triazol-5-one-4-ylazomethine-phenyl 3-methoxybenzoates 3. The compounds 3 were also treated with 4- piperidinecarboxamide in the presence of formaldehyde according to the Mannich reaction to synthesize 2-ethoxy-4-3- alkylaryl-1-4-piperidinecarboxamide-1-yl-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl-azomethine-phenyl 3- methoxy-benzoates 4. The structures of Schiff base and Mannich base derivatives were identified with spectral methods. Antimicrobial and antioxidant screening were carried out and discussed. Mannich base derivatives were found to be more active than Schiff bases in the biological screening. The effect values of Mannich Base derivatives dominate Neomycin and Streptomycin antibiotics.

 In the present study, 3-alkylaryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 1 reacted with 3-ethoxy-4- 3-methoxybenzoxy-benzaldehyde 2 to obtain the corresponding nine new 2-ethoxy-4-3-alkylaryl-4,5-dihydro-1H- 1,2,4-triazol-5-one-4-ylazomethine-phenyl 3-methoxybenzoates 3. The compounds 3 were also treated with 4- piperidinecarboxamide in the presence of formaldehyde according to the Mannich reaction to synthesize 2-ethoxy-4-3- alkylaryl-1-4-piperidinecarboxamide-1-yl-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl-azomethine-phenyl 3- methoxy-benzoates 4. The structures of Schiff base and Mannich base derivatives were identified with spectral methods. Antimicrobial and antioxidant screening were carried out and discussed. Mannich base derivatives were found to be more active than Schiff bases in the biological screening. The effect values of Mannich Base derivatives dominate Neomycin and Streptomycin antibiotics.

 In the present study, 3-alkylaryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 1 reacted with 3-ethoxy-4- 3-methoxybenzoxy-benzaldehyde 2 to obtain the corresponding nine new 2-ethoxy-4-3-alkylaryl-4,5-dihydro-1H- 1,2,4-triazol-5-one-4-ylazomethine-phenyl 3-methoxybenzoates 3. The compounds 3 were also treated with 4- piperidinecarboxamide in the presence of formaldehyde according to the Mannich reaction to synthesize 2-ethoxy-4-3- alkylaryl-1-4-piperidinecarboxamide-1-yl-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl-azomethine-phenyl 3- methoxy-benzoates 4. The structures of Schiff base and Mannich base derivatives were identified with spectral methods. Antimicrobial and antioxidant screening were carried out and discussed. Mannich base derivatives were found to be more active than Schiff bases in the biological screening. The effect values of Mannich Base derivatives dominate Neomycin and Streptomycin antibiotics.

 In the present study, 3-alkylaryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 1 reacted with 3-ethoxy-4- 3-methoxybenzoxy-benzaldehyde 2 to obtain the corresponding nine new 2-ethoxy-4-3-alkylaryl-4,5-dihydro-1H- 1,2,4-triazol-5-one-4-ylazomethine-phenyl 3-methoxybenzoates 3. The compounds 3 were also treated with 4- piperidinecarboxamide in the presence of formaldehyde according to the Mannich reaction to synthesize 2-ethoxy-4-3- alkylaryl-1-4-piperidinecarboxamide-1-yl-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl-azomethine-phenyl 3- methoxy-benzoates 4. The structures of Schiff base and Mannich base derivatives were identified with spectral methods. Antimicrobial and antioxidant screening were carried out and discussed. Mannich base derivatives were found to be more active than Schiff bases in the biological screening. The effect values of Mannich Base derivatives dominate Neomycin and Streptomycin antibiotics.

Makale detayları

Antibacterial and antioxidant activities of novel 2-ethoxy- 4-[(4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azomethine]- phenyl 3-methoxybenzoate derivatives

Yazarlar:

Özlem Gürsoy Kol | Sevda Manap | Murat Beytur | Fevzi Aytemiz | Muzaffer Alkan | Haydar Yüksek

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 2, pp.692-704

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341715

pISSN:

2630-6344

Schiff base

Mannich base

1

2

4-triazole-5-one

antimicrobial activity

antioxidant activity

Sayı

Makale detayları

Yazarlar: Özlem Gürsoy Kol | Sevda Manap | Murat Beytur | Fevzi Aytemiz | Muzaffer Alkan | Haydar Yüksek

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.29 Issue 2, pp.692-704

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001341715

pISSN: 2630-6344

Sayı

Yazarlar:

Özlem Gürsoy Kol | Sevda Manap | Murat Beytur | Fevzi Aytemiz | Muzaffer Alkan | Haydar Yüksek

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 2, pp.692-704

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341715

pISSN:

2630-6344