Assessment of the Effect of Psoriasis and Methotrexate Treatment on Liver Stiffness by ARFI Imaging

Derya Güçlü; Ebru Karagün; Elif Nisa Unlu; Mehtap Oktay; Özge Pasin

Makale detayları

Assessment of the Effect of Psoriasis and Methotrexate Treatment on Liver Stiffness by ARFI Imaging

Yazarlar:

Derya Güçlü | Ebru Karagün | Elif Nisa Unlu | Mehtap Oktay | Özge Pasin

Yayıncı:

Duzce University

Ana Başlıklar:

Health Care Administration

Dergi:

Konuralp Medical Journal Vol.15 Issue 2, pp.243-247

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292052

pISSN:

1309-3878

Anahtar kelimeler:

Özet:

 Objective: To investigate whether psoriasis and methotrexate used in its treatment cause liver fibrosis and eventually to evaluate the safety of methotrexate in treatment. Method: 44 cases were included in the study. Methotrexate-using group 1, n14 and methotrexate-not-using group 2, n13 psoriasis patients were compared retrospectively with a healthy control group group 3, n17 according to mean shear wave rates obtained from sonoelastographic examinations with ARFI technique. Results: Mean shear wave velocities were calculated as 2.57  1.13 msec in the patients using methotrexate, 2.31  1.16 msec in the patients who did not use methotrexate, and 1.56  0.62 msec in the healthy control group. While the average shear wave velocity of the 3rd group was found to be significantly lower than that of the 1st and 2nd groups p0.032; p0.012, no significant difference was observed between the 1st and 2nd groups p0.755. Conclusion: We think that the increase in liver tissue stiffness in patients using methotrexate for psoriasis is secondary to the inflammatory process caused by psoriasis itself rather than methotrexate, and methotrexate is safe for the liver in treatment.

 Objective: To investigate whether psoriasis and methotrexate used in its treatment cause liver fibrosis and eventually to evaluate the safety of methotrexate in treatment. Method: 44 cases were included in the study. Methotrexate-using group 1, n14 and methotrexate-not-using group 2, n13 psoriasis patients were compared retrospectively with a healthy control group group 3, n17 according to mean shear wave rates obtained from sonoelastographic examinations with ARFI technique. Results: Mean shear wave velocities were calculated as 2.57  1.13 msec in the patients using methotrexate, 2.31  1.16 msec in the patients who did not use methotrexate, and 1.56  0.62 msec in the healthy control group. While the average shear wave velocity of the 3rd group was found to be significantly lower than that of the 1st and 2nd groups p0.032; p0.012, no significant difference was observed between the 1st and 2nd groups p0.755. Conclusion: We think that the increase in liver tissue stiffness in patients using methotrexate for psoriasis is secondary to the inflammatory process caused by psoriasis itself rather than methotrexate, and methotrexate is safe for the liver in treatment.

 Objective: To investigate whether psoriasis and methotrexate used in its treatment cause liver fibrosis and eventually to evaluate the safety of methotrexate in treatment. Method: 44 cases were included in the study. Methotrexate-using group 1, n14 and methotrexate-not-using group 2, n13 psoriasis patients were compared retrospectively with a healthy control group group 3, n17 according to mean shear wave rates obtained from sonoelastographic examinations with ARFI technique. Results: Mean shear wave velocities were calculated as 2.57  1.13 msec in the patients using methotrexate, 2.31  1.16 msec in the patients who did not use methotrexate, and 1.56  0.62 msec in the healthy control group. While the average shear wave velocity of the 3rd group was found to be significantly lower than that of the 1st and 2nd groups p0.032; p0.012, no significant difference was observed between the 1st and 2nd groups p0.755. Conclusion: We think that the increase in liver tissue stiffness in patients using methotrexate for psoriasis is secondary to the inflammatory process caused by psoriasis itself rather than methotrexate, and methotrexate is safe for the liver in treatment.

 Amaç: Psöriazisin ve tedavisinde kullanılan metotreksatın karaciğer fibrozisine neden olup olmadığını araştırmak ve böylelikle metotreksatın tedavideki güvenilirliğini değerlendirmektir. Gereç ve Yöntem: Çalışmaya 44 olgu dahil edildi. Psöriasis tanılı olup metotreksat kullanan grup 1, n4 ve metotreksat kullanmayan grup 2, n13 hastalar ile sağlıklı kontrol grubunun grup 3, n17 Akustik Radyasyon Kuvveti İmpulsu ARFI tekniği ile yapılmış sonoelastografik incelemelerinde shear wave hız ortalamaları retrospektif olarak karşılaştırılmıştır. Bulgular: Ortalama shear wave hızları metotreksat kullanan hastalarda 2,57  1,13 msn, metotreksat kullanmayan hasta grubunda 2,31  1,16 msn, sağlıklı kontrol grubunda ise 1,56  0,62 msn olarak hesaplanmış olup 3. grubun shear wave hız ortalaması 1 ve 2. gruptan anlamlı derecede düşük bulunurken p0,032; p0,012, 1 ve 2. gruplar arasında anlamlı farklılık gözlenmemiştir p0,755. Sonuç: ARFI kuantifikasyon ile yapılan shear wave görüntüleme bulguları psöriasis hastalarında metotreksat tedavisinin karaciğer fibrozu ile ilişkili olmadığını ve psöriazis nedeniyle metotreksat kullanan hastalarda ortaya çıkan karaciğer doku sertliği artışının, metotreksattan ziyade, psöriazisin neden olduğu inflamatuar sürece sekonder olduğunu düşündürmüştür.

Makale detayları

Assessment of the Effect of Psoriasis and Methotrexate Treatment on Liver Stiffness by ARFI Imaging

Yazarlar:

Derya Güçlü | Ebru Karagün | Elif Nisa Unlu | Mehtap Oktay | Özge Pasin

Yayıncı:

Duzce University

Ana Başlıklar:

Health Care Administration

Dergi:

Konuralp Medical Journal Vol.15 Issue 2, pp.243-247

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292052

pISSN:

1309-3878

ARFI

Methotrexate

Psoriasis

Shear wave elastographyARFI

Metotreksat

Psöriazis

Shear Wave Elastograf

Sayı

Makale detayları

Yazarlar: Derya Güçlü | Ebru Karagün | Elif Nisa Unlu | Mehtap Oktay | Özge Pasin

Yayıncı: Duzce University

Ana Başlıklar: Health Care Administration

Dergi: Konuralp Medical Journal Vol.15 Issue 2, pp.243-247

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001292052

pISSN: 1309-3878

Sayı

Yazarlar:

Derya Güçlü | Ebru Karagün | Elif Nisa Unlu | Mehtap Oktay | Özge Pasin

Yayıncı:

Duzce University

Ana Başlıklar:

Health Care Administration

Dergi:

Konuralp Medical Journal Vol.15 Issue 2, pp.243-247

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292052

pISSN:

1309-3878