Normative hippocampal volumetric measurements using magnetic resonance imaging

Meltem ÖZDEMİR; Handan SOYSAL; Önder ERASLAN; Alper DİLLİ

Makale detayları

Normative hippocampal volumetric measurements using magnetic resonance imaging

Yazarlar:

Meltem ÖZDEMİR | Handan SOYSAL | Önder ERASLAN | Alper DİLLİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 5, pp.1464-1470

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749891

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim:  A  wide  variety  of  neurological  and  psychiatric  disorders  have  been  shown  to  be  closely  related  to  changes  in  hippocampal volume (HV). It appears that hippocampal volumetry will be an indispensable part of clinical practice for a number of neuropsychiatric disorders in the near future. The aim of this study was to establish a normative data set for HV according to age and sex in the general population.Materials  and  methods:  Hippocampal  magnetic  resonance  imaging  scans  of  302  healthy  volunteers  were  obtained  using  a  1.5  T  unit  with a 20-channel head coil. The hippocampal volumetric assessment was conducted using the volBrain fully automated segmentation algorithm on coronal oblique T1-weighted magnetization prepared rapid gradient-echo (MP-RAGE) images obtained perpendicular to the long axis of the hippocampus. The mean values of HV of groups according to age and sex were calculated. The associations between HV and age and sex were analyzed. Results: The mean HV of the study group was found to be 3.81 ± 0.46 cm3. We found that the mean HV of males (3.94 ± 0.49 cm3) was significantly higher than that of females (3.74 ± 0.42 cm3), and the mean right HV (3.86 ± 0.48 cm3) was significantly higher than that of the left HV (3.78 ± 0.49 cm3) (P = 0.001). Among both females and males, there were statistically significant but poor negative correlations between age and volumetric measurements of both the right and the left hippocampi (P < 0.05).Conclusion:  The  normative  hippocampal  volumetric  data  obtained  in  this  study  may  be  beneficial  in  clinical  applications  for  many  neuropsychiatric diseases, especially for mesial temporal sclerosis and cognitive disorders.

Makale detayları

Normative hippocampal volumetric measurements using magnetic resonance imaging

Yazarlar: Meltem ÖZDEMİR | Handan SOYSAL | Önder ERASLAN | Alper DİLLİ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 5, pp.1464-1470

Belge Tipi: Makale

Yayın Tarihi: 9/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000749891

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Meltem ÖZDEMİR | Handan SOYSAL | Önder ERASLAN | Alper DİLLİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 5, pp.1464-1470

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749891

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144