The role of oxidative stress in α-amanitin-induced hepatotoxicity  in an experimental mouse model

Zerrin Defne DÜNDAR; Mehmet ERGİN; İbrahim KILINÇ; Tamer ÇOLAK; Pembe OLTULU; Başar CANDER

Makale detayları

The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model

Yazarlar:

Zerrin Defne DÜNDAR | Mehmet ERGİN | İbrahim KILINÇ | Tamer ÇOLAK | Pembe OLTULU | Başar CANDER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.318-325

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751625

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: This study aimed to evaluate oxidative stress markers of liver tissue in a mouse α-amanitin poisoning model with three different toxin levels.   Materials and methods: The mice were randomly divided into Group 1 (control), Group 2 (0.2 mg/kg), Group 3 (0.6 mg/kg), and Group 4 (1.0 mg/kg). The toxin was injected intraperitoneally and 48 h of follow-up was performed before sacrifice.   Results: Median superoxide dismutase activities of liver tissue in Groups 3 and 4 were significantly higher than in Group 1 (for both, P = 0.001). The catalase activity in Group 2 was significantly higher, but in Groups 3 and 4 it was significantly lower than in Group 1 (for all, P = 0.001). The glutathione peroxidase activities in Groups 2, 3, and 4 were significantly higher than in Group 1 (P = 0.006, P = 0.001, and P = 0.001, respectively). The malondialdehyde levels of Groups 3 and 4 were significantly higher than Group 1 (P = 0.015 and P = 0.003, respectively). The catalase activity had significant correlations with total antioxidant status and total oxidant status levels (r = 0.935 and r = -0.789, respectively; for both, P < 0.001).   Conclusion: Our findings support a significant role for increased oxidative stress in α-amanitin-induced hepatotoxicity.

Makale detayları

The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model

Yazarlar: Zerrin Defne DÜNDAR | Mehmet ERGİN | İbrahim KILINÇ | Tamer ÇOLAK | Pembe OLTULU | Başar CANDER

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.318-325

Belge Tipi: Makale

Yayın Tarihi: 1/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000751625

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Zerrin Defne DÜNDAR | Mehmet ERGİN | İbrahim KILINÇ | Tamer ÇOLAK | Pembe OLTULU | Başar CANDER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.318-325

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751625

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144