Frequency of seronegative cases in autoimmune hepatitis and their association with the systemic immune inflammation index

Nermin Mutlu Bilgiç

Makale detayları

Frequency of seronegative cases in autoimmune hepatitis and their association with the systemic immune inflammation index

Yazarlar:

Nermin Mutlu Bilgiç

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji

Dergi:

Journal of Health Sciences and Medicine Vol.7 Issue 2, pp.230-235

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314066

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aims: It is suggested that a deficiency in B cells plays a role in pathogenesis of seronegative autoimmune hepatitis snAIH. The lack of B cells leads to notable changes in the variety of leukocyte types within the bloodstream. This study aimed to determine the frequency of snAIH in patients with autoimmune hepatitis, as well as to explore the relationship between snAIH and leukocyte-based inflammatory indices. Methods: In this retrospective study, 57 patients newly diagnosed with autoimmune hepatitis were included. According to clinical and pathological findings, patients were classified into seropositive autoimmune hepatitis spAIH and snAIH groups. The inflammation indices included the platelet to lymphocyte ratio PLR, the neutrophil to lymphocyte ratio NLR, and the systemic immune-inflammation index SII. Results: The frequency of snAIH was 26.3. The snAIH group exhibited higher NLR 3.0 vs. 1.5, p0.001 and SII 726.1 vs. 300.8, p0.001 levels, along with a lower PLR level 118.2 vs. 151.1, p0.001 than the spAIH group. The threshold value of SII in predicting snAIH was 488.4 sensitivity80.9, specificity86.7, and it exhibited better diagnostic performance than other inflammatory indices. Conclusion: In autoimmune hepatitis patients, snAIH exhibits by a notable prevalence and a different inflammatory landscape. For patients suspected of autoimmune hepatitis but negative for autoantibodies, the SII could serve as a straightforward, accessible, and affordable predictor prior to liver biopsy.

 Aims: It is suggested that a deficiency in B cells plays a role in pathogenesis of seronegative autoimmune hepatitis snAIH. The lack of B cells leads to notable changes in the variety of leukocyte types within the bloodstream. This study aimed to determine the frequency of snAIH in patients with autoimmune hepatitis, as well as to explore the relationship between snAIH and leukocyte-based inflammatory indices. Methods: In this retrospective study, 57 patients newly diagnosed with autoimmune hepatitis were included. According to clinical and pathological findings, patients were classified into seropositive autoimmune hepatitis spAIH and snAIH groups. The inflammation indices included the platelet to lymphocyte ratio PLR, the neutrophil to lymphocyte ratio NLR, and the systemic immune-inflammation index SII. Results: The frequency of snAIH was 26.3. The snAIH group exhibited higher NLR 3.0 vs. 1.5, p0.001 and SII 726.1 vs. 300.8, p0.001 levels, along with a lower PLR level 118.2 vs. 151.1, p0.001 than the spAIH group. The threshold value of SII in predicting snAIH was 488.4 sensitivity80.9, specificity86.7, and it exhibited better diagnostic performance than other inflammatory indices. Conclusion: In autoimmune hepatitis patients, snAIH exhibits by a notable prevalence and a different inflammatory landscape. For patients suspected of autoimmune hepatitis but negative for autoantibodies, the SII could serve as a straightforward, accessible, and affordable predictor prior to liver biopsy.

 Aims: It is suggested that a deficiency in B cells plays a role in pathogenesis of seronegative autoimmune hepatitis snAIH. The lack of B cells leads to notable changes in the variety of leukocyte types within the bloodstream. This study aimed to determine the frequency of snAIH in patients with autoimmune hepatitis, as well as to explore the relationship between snAIH and leukocyte-based inflammatory indices. Methods: In this retrospective study, 57 patients newly diagnosed with autoimmune hepatitis were included. According to clinical and pathological findings, patients were classified into seropositive autoimmune hepatitis spAIH and snAIH groups. The inflammation indices included the platelet to lymphocyte ratio PLR, the neutrophil to lymphocyte ratio NLR, and the systemic immune-inflammation index SII. Results: The frequency of snAIH was 26.3. The snAIH group exhibited higher NLR 3.0 vs. 1.5, p0.001 and SII 726.1 vs. 300.8, p0.001 levels, along with a lower PLR level 118.2 vs. 151.1, p0.001 than the spAIH group. The threshold value of SII in predicting snAIH was 488.4 sensitivity80.9, specificity86.7, and it exhibited better diagnostic performance than other inflammatory indices. Conclusion: In autoimmune hepatitis patients, snAIH exhibits by a notable prevalence and a different inflammatory landscape. For patients suspected of autoimmune hepatitis but negative for autoantibodies, the SII could serve as a straightforward, accessible, and affordable predictor prior to liver biopsy.

 Aims: It is suggested that a deficiency in B cells plays a role in pathogenesis of seronegative autoimmune hepatitis snAIH. The lack of B cells leads to notable changes in the variety of leukocyte types within the bloodstream. This study aimed to determine the frequency of snAIH in patients with autoimmune hepatitis, as well as to explore the relationship between snAIH and leukocyte-based inflammatory indices. Methods: In this retrospective study, 57 patients newly diagnosed with autoimmune hepatitis were included. According to clinical and pathological findings, patients were classified into seropositive autoimmune hepatitis spAIH and snAIH groups. The inflammation indices included the platelet to lymphocyte ratio PLR, the neutrophil to lymphocyte ratio NLR, and the systemic immune-inflammation index SII. Results: The frequency of snAIH was 26.3. The snAIH group exhibited higher NLR 3.0 vs. 1.5, p0.001 and SII 726.1 vs. 300.8, p0.001 levels, along with a lower PLR level 118.2 vs. 151.1, p0.001 than the spAIH group. The threshold value of SII in predicting snAIH was 488.4 sensitivity80.9, specificity86.7, and it exhibited better diagnostic performance than other inflammatory indices. Conclusion: In autoimmune hepatitis patients, snAIH exhibits by a notable prevalence and a different inflammatory landscape. For patients suspected of autoimmune hepatitis but negative for autoantibodies, the SII could serve as a straightforward, accessible, and affordable predictor prior to liver biopsy.

Makale detayları

Frequency of seronegative cases in autoimmune hepatitis and their association with the systemic immune inflammation index

Yazarlar:

Nermin Mutlu Bilgiç

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji

Dergi:

Journal of Health Sciences and Medicine Vol.7 Issue 2, pp.230-235

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314066

pISSN:

2636-8579

Autoimmune hepatitis

Seronegative

inflammation index

Sayı

Makale detayları

Frequency of seronegative cases in autoimmune hepatitis and their association with the systemic immune inflammation index

Yazarlar: Nermin Mutlu Bilgiç

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Gastroenteroloji ve Hepatoloji

Dergi: Journal of Health Sciences and Medicine Vol.7 Issue 2, pp.230-235

Belge Tipi: Makale

Yayın Tarihi: 3/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001314066

pISSN: 2636-8579

Autoimmune hepatitis

Seronegative

inflammation index

Sayı

Yazarlar:

Nermin Mutlu Bilgiç

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji

Dergi:

Journal of Health Sciences and Medicine Vol.7 Issue 2, pp.230-235

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314066

pISSN:

2636-8579