Serum galectin-3 levels and vitamin D relationship in heart failure

Mustafa ÖZCAN; Murat AKARSU; Şengül AYDIN YOLDEMİR; Özgür ALTUN; Orkide KUTLU; Semih KALYON; Gülden YÜRÜYEN; Perihan ÖZKAN GÜMÜŞKAYA; Neslihan ÖZSOY; Hasan ERUZUN; Yücel ARMAN; Tufan TÜKEK

doi:https://doi.org/10.28982/josam.1003992

Makale detayları

Serum galectin-3 levels and vitamin D relationship in heart failure

Yazarlar:

Mustafa ÖZCAN | Murat AKARSU | Şengül AYDIN YOLDEMİR | Özgür ALTUN | Orkide KUTLU | Semih KALYON | Gülden YÜRÜYEN | Perihan ÖZKAN GÜMÜŞKAYA | Neslihan ÖZSOY | Hasan ERUZUN | Yücel ARMAN | Tufan TÜKEK

Yayıncı:

Fatih BAŞAK

Ana Başlıklar:

Hastalıklar

Dergi:

Journal of Surgery and Medicine 2021 Vol.5 Issue 10, pp.1046-1049

Belge Tipi:

Makale

Yayın Tarihi:

9/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000498430

Sıklık:

Aylık

eISSN:

2602-2079

DOI:

https://doi.org/10.28982/josam.1003992

Özet:

 

Background/Aim: Heart failure is an important health problem with an increasing incidence in the world and poor prognosis. Galectin-3 is associated with progressive fibrosis, an underlying pathology of heart failure, just as vitamin D deficiency. We examined the relationship between the stage of heart failure and galectin-3 and 25-OH vitamin D levels.
Methods: Sixty patients with heart failure and 30 healthy volunteers were included in this prospective case-control study. Demographic data, comorbid diseases and laboratory data were examined, and 25-OH vitamin D and galectin-3 levels were compared between the patients with CHF and the control group.
Results: Galectin-3 levels were high in patients with heart failure (P<0.001) and increased as the ejection fraction (EF) decreased (P=0.001). 25-OH vitamin D levels were lower in the patient group compared to the control group (P<0.001). There was no significant correlation between serum galectin-3 and vitamin D levels (r=-0.22; P=0.094); however, serum galectin-3 levels and the stage of CHF were correlated (r=0.66; P=0.001).
Conclusions: We found high serum galectin-3 levels in patients with heart failure and low 25 OH vitamin D levels. We think that both molecules are important prognostic biomarkers in cardiac inflammation and fibrosis.

Makale detayları

Serum galectin-3 levels and vitamin D relationship in heart failure

Yazarlar: Mustafa ÖZCAN | Murat AKARSU | Şengül AYDIN YOLDEMİR | Özgür ALTUN | Orkide KUTLU | Semih KALYON | Gülden YÜRÜYEN | Perihan ÖZKAN GÜMÜŞKAYA | Neslihan ÖZSOY | Hasan ERUZUN | Yücel ARMAN | Tufan TÜKEK

Yayıncı: Fatih BAŞAK

Ana Başlıklar: Hastalıklar

Dergi: Journal of Surgery and Medicine 2021 Vol.5 Issue 10, pp.1046-1049

Belge Tipi: Makale

Yayın Tarihi: 9/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000498430

Sıklık: Aylık

eISSN: 2602-2079

DOI: https://doi.org/10.28982/josam.1003992

Sayı

Yazarlar:

Mustafa ÖZCAN | Murat AKARSU | Şengül AYDIN YOLDEMİR | Özgür ALTUN | Orkide KUTLU | Semih KALYON | Gülden YÜRÜYEN | Perihan ÖZKAN GÜMÜŞKAYA | Neslihan ÖZSOY | Hasan ERUZUN | Yücel ARMAN | Tufan TÜKEK

Yayıncı:

Fatih BAŞAK

Ana Başlıklar:

Hastalıklar

Dergi:

Journal of Surgery and Medicine 2021 Vol.5 Issue 10, pp.1046-1049

Belge Tipi:

Makale

Yayın Tarihi:

9/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000498430

Sıklık:

Aylık

eISSN:

2602-2079

DOI:

https://doi.org/10.28982/josam.1003992