Association between disease activity and HALP score in ankylosing spondylitis patients

Osman Cüre

Makale detayları

Association between disease activity and HALP score in ankylosing spondylitis patients

Yazarlar:

Osman Cüre

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Rheumatology and Arthritis

Dergi:

The European Research Journal Vol.11 Issue 2, pp.251-259

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341268

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objective: The goal of this research was to assess HALP score Hemoglobin, Albumin, Lymphocyte, Platelet as a potential indicator of disease activity among patients with Ankylosing Spondylitis AS. Methods: Data from 260 individuals 130 AS patients and 130 healthy controls were retrospectively reviewed. Clinical and demographic information was collected, and the AS group was divided into remission and active disease subgroups for comparison. Results: In contrast to the group of healthy controls, AS patients had a lower HALP score P0.001. The HALP score was notably lower in the active patient group than in the remission group P0.025. The HALP score and the erythrocyte sedimentation rate were found to be negatively correlated r-0.307, P0.001. Additionally, significant negative correlations were identified between the HALP score and the following parameters: Bath Ankylosing Spondylitis Disease Activity Index BASDAI r-0.208, P0.017, Bath Ankylosing Spondylitis Functional Index BASFI r-0.195, P0.026, Ankylosing Spondylitis Disease Activity Score using C-reactive protein ASDAS-CRP r-0.199, P0.024, and Visual Analog Scale r-0.229, P0.009. The optimal HALP score cut-off for determining disease activity was established as 0.56 AUC: 0.619, 95 CI: 0.518-0.721, sensitivity: 80.00, specificity: 40.00. Conclusions: This study found that the HALP score was lower in active AS patients compared to those in remission. Therefore, the HALP score may serve as a potential marker for assessing disease activity in AS patients.

 Objective: The goal of this research was to assess HALP score Hemoglobin, Albumin, Lymphocyte, Platelet as a potential indicator of disease activity among patients with Ankylosing Spondylitis AS. Methods: Data from 260 individuals 130 AS patients and 130 healthy controls were retrospectively reviewed. Clinical and demographic information was collected, and the AS group was divided into remission and active disease subgroups for comparison. Results: In contrast to the group of healthy controls, AS patients had a lower HALP score P0.001. The HALP score was notably lower in the active patient group than in the remission group P0.025. The HALP score and the erythrocyte sedimentation rate were found to be negatively correlated r-0.307, P0.001. Additionally, significant negative correlations were identified between the HALP score and the following parameters: Bath Ankylosing Spondylitis Disease Activity Index BASDAI r-0.208, P0.017, Bath Ankylosing Spondylitis Functional Index BASFI r-0.195, P0.026, Ankylosing Spondylitis Disease Activity Score using C-reactive protein ASDAS-CRP r-0.199, P0.024, and Visual Analog Scale r-0.229, P0.009. The optimal HALP score cut-off for determining disease activity was established as 0.56 AUC: 0.619, 95 CI: 0.518-0.721, sensitivity: 80.00, specificity: 40.00. Conclusions: This study found that the HALP score was lower in active AS patients compared to those in remission. Therefore, the HALP score may serve as a potential marker for assessing disease activity in AS patients.

 Objective: The goal of this research was to assess HALP score Hemoglobin, Albumin, Lymphocyte, Platelet as a potential indicator of disease activity among patients with Ankylosing Spondylitis AS. Methods: Data from 260 individuals 130 AS patients and 130 healthy controls were retrospectively reviewed. Clinical and demographic information was collected, and the AS group was divided into remission and active disease subgroups for comparison. Results: In contrast to the group of healthy controls, AS patients had a lower HALP score P0.001. The HALP score was notably lower in the active patient group than in the remission group P0.025. The HALP score and the erythrocyte sedimentation rate were found to be negatively correlated r-0.307, P0.001. Additionally, significant negative correlations were identified between the HALP score and the following parameters: Bath Ankylosing Spondylitis Disease Activity Index BASDAI r-0.208, P0.017, Bath Ankylosing Spondylitis Functional Index BASFI r-0.195, P0.026, Ankylosing Spondylitis Disease Activity Score using C-reactive protein ASDAS-CRP r-0.199, P0.024, and Visual Analog Scale r-0.229, P0.009. The optimal HALP score cut-off for determining disease activity was established as 0.56 AUC: 0.619, 95 CI: 0.518-0.721, sensitivity: 80.00, specificity: 40.00. Conclusions: This study found that the HALP score was lower in active AS patients compared to those in remission. Therefore, the HALP score may serve as a potential marker for assessing disease activity in AS patients.

 Objective: The goal of this research was to assess HALP score Hemoglobin, Albumin, Lymphocyte, Platelet as a potential indicator of disease activity among patients with Ankylosing Spondylitis AS. Methods: Data from 260 individuals 130 AS patients and 130 healthy controls were retrospectively reviewed. Clinical and demographic information was collected, and the AS group was divided into remission and active disease subgroups for comparison. Results: In contrast to the group of healthy controls, AS patients had a lower HALP score P0.001. The HALP score was notably lower in the active patient group than in the remission group P0.025. The HALP score and the erythrocyte sedimentation rate were found to be negatively correlated r-0.307, P0.001. Additionally, significant negative correlations were identified between the HALP score and the following parameters: Bath Ankylosing Spondylitis Disease Activity Index BASDAI r-0.208, P0.017, Bath Ankylosing Spondylitis Functional Index BASFI r-0.195, P0.026, Ankylosing Spondylitis Disease Activity Score using C-reactive protein ASDAS-CRP r-0.199, P0.024, and Visual Analog Scale r-0.229, P0.009. The optimal HALP score cut-off for determining disease activity was established as 0.56 AUC: 0.619, 95 CI: 0.518-0.721, sensitivity: 80.00, specificity: 40.00. Conclusions: This study found that the HALP score was lower in active AS patients compared to those in remission. Therefore, the HALP score may serve as a potential marker for assessing disease activity in AS patients.

Makale detayları

Association between disease activity and HALP score in ankylosing spondylitis patients

Yazarlar:

Osman Cüre

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Rheumatology and Arthritis

Dergi:

The European Research Journal Vol.11 Issue 2, pp.251-259

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341268

pISSN:

2149-3189

Inflammation marker

HALP score

ankylosing spondylitis

Sayı

Makale detayları

Association between disease activity and HALP score in ankylosing spondylitis patients

Yazarlar: Osman Cüre

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Rheumatology and Arthritis

Dergi: The European Research Journal Vol.11 Issue 2, pp.251-259

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001341268

pISSN: 2149-3189

Inflammation marker

HALP score

ankylosing spondylitis

Sayı

Yazarlar:

Osman Cüre

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Rheumatology and Arthritis

Dergi:

The European Research Journal Vol.11 Issue 2, pp.251-259

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341268

pISSN:

2149-3189