Synthesis of Some New Dihalophenyl- and Dihalobenzylisocoumarins and Their (dl)-3,4-Dihydroderivatives

Zahid SHAFIQ; Muhammad ARFAN; Nasim Hasan RAMA; Shahid HAMEED; Ghulam ABBAS; Muhammad Tahir HUSSAIN

Makale detayları

Synthesis of Some New Dihalophenyl- and Dihalobenzylisocoumarins and Their (dl)-3,4-Dihydroderivatives

Yazarlar:

Zahid SHAFIQ | Muhammad ARFAN | Nasim Hasan RAMA | Shahid HAMEED | Ghulam ABBAS | Muhammad Tahir HUSSAIN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2005 Vol.29 Issue 3, pp.321-325

Belge Tipi:

Makale

Yayın Tarihi:

2/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000729112

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

3-Dihalophenyl- and dihalobenzylisocoumarins (3a-c) were  synthesized by condensation of homophthalic acid (1) with  dihalobenzoyl- and dihalophenylacetyl chlorides (2a-c), respectively.   The alkaline hydrolysis of these isocoumarins (2a-c) afforded  keto-acids (4a-c).  (dl)-3-(Dihalophenyl)- and (dl)-3-(dihalobenzyl)-  3,4-dihydroisocoumarins (6a-c) were obtained by reduction of  keto-acids (4a-c) to racemic hydroxy-acids (5a-c) followed by  cyclodehydration using acetic anhydride.

 

3-Dihalophenyl- and dihalobenzylisocoumarins (3a-c) were  synthesized by condensation of homophthalic acid (1) with  dihalobenzoyl- and dihalophenylacetyl chlorides (2a-c), respectively.   The alkaline hydrolysis of these isocoumarins (2a-c) afforded  keto-acids (4a-c).  (dl)-3-(Dihalophenyl)- and (dl)-3-(dihalobenzyl)-  3,4-dihydroisocoumarins (6a-c) were obtained by reduction of  keto-acids (4a-c) to racemic hydroxy-acids (5a-c) followed by  cyclodehydration using acetic anhydride.

Makale detayları

Synthesis of Some New Dihalophenyl- and Dihalobenzylisocoumarins and Their (dl)-3,4-Dihydroderivatives

Yazarlar: Zahid SHAFIQ | Muhammad ARFAN | Nasim Hasan RAMA | Shahid HAMEED | Ghulam ABBAS | Muhammad Tahir HUSSAIN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2005 Vol.29 Issue 3, pp.321-325

Belge Tipi: Makale

Yayın Tarihi: 2/2005

Belge Dili: Türkçe

Document ID (Org No.): 2000729112

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Zahid SHAFIQ | Muhammad ARFAN | Nasim Hasan RAMA | Shahid HAMEED | Ghulam ABBAS | Muhammad Tahir HUSSAIN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2005 Vol.29 Issue 3, pp.321-325

Belge Tipi:

Makale

Yayın Tarihi:

2/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000729112

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527