A comprehensive review on triazoles as anticancer agents

Merve Camci Eren; Özlen Güzel Akdemir

Makale detayları

A comprehensive review on triazoles as anticancer agents

Yazarlar:

Merve Camci Eren | Özlen Güzel Akdemir

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 2, pp.639-666

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341711

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Despite the advancements in anticancer drug design, new pharmacological compounds that are safer, more effective, and able to stop the emergence of resistance to themselves are still desperately needed. Triazoles have a broad range of biological activities, including anticancer, antiviral, and antibacterial activities. Also, they can interact with diverse enzyme systems via hydrogen bonds, electrostatic interactions, and other mechanisms. Due to these advantages, triazoles have become one of the most popular scaffolds in medicinal chemistry and have attracted researchers attention. In this review, a comprehensive overview of recent advances in anticancer triazoles, focusing on developments within the last five years, their classification based on their mode of action and synthesis methodology, and a summary of historical progress in synthesis techniques are provided to offer researchers a broad perspective.

 Despite the advancements in anticancer drug design, new pharmacological compounds that are safer, more effective, and able to stop the emergence of resistance to themselves are still desperately needed. Triazoles have a broad range of biological activities, including anticancer, antiviral, and antibacterial activities. Also, they can interact with diverse enzyme systems via hydrogen bonds, electrostatic interactions, and other mechanisms. Due to these advantages, triazoles have become one of the most popular scaffolds in medicinal chemistry and have attracted researchers attention. In this review, a comprehensive overview of recent advances in anticancer triazoles, focusing on developments within the last five years, their classification based on their mode of action and synthesis methodology, and a summary of historical progress in synthesis techniques are provided to offer researchers a broad perspective.

 Despite the advancements in anticancer drug design, new pharmacological compounds that are safer, more effective, and able to stop the emergence of resistance to themselves are still desperately needed. Triazoles have a broad range of biological activities, including anticancer, antiviral, and antibacterial activities. Also, they can interact with diverse enzyme systems via hydrogen bonds, electrostatic interactions, and other mechanisms. Due to these advantages, triazoles have become one of the most popular scaffolds in medicinal chemistry and have attracted researchers attention. In this review, a comprehensive overview of recent advances in anticancer triazoles, focusing on developments within the last five years, their classification based on their mode of action and synthesis methodology, and a summary of historical progress in synthesis techniques are provided to offer researchers a broad perspective.

 Despite the advancements in anticancer drug design, new pharmacological compounds that are safer, more effective, and able to stop the emergence of resistance to themselves are still desperately needed. Triazoles have a broad range of biological activities, including anticancer, antiviral, and antibacterial activities. Also, they can interact with diverse enzyme systems via hydrogen bonds, electrostatic interactions, and other mechanisms. Due to these advantages, triazoles have become one of the most popular scaffolds in medicinal chemistry and have attracted researchers attention. In this review, a comprehensive overview of recent advances in anticancer triazoles, focusing on developments within the last five years, their classification based on their mode of action and synthesis methodology, and a summary of historical progress in synthesis techniques are provided to offer researchers a broad perspective.

Makale detayları

A comprehensive review on triazoles as anticancer agents

Yazarlar:

Merve Camci Eren | Özlen Güzel Akdemir

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 2, pp.639-666

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341711

pISSN:

2630-6344

triazole

anticancer

synthesis

activity

molecular modelling

Sayı

Makale detayları

A comprehensive review on triazoles as anticancer agents

Yazarlar: Merve Camci Eren | Özlen Güzel Akdemir

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Chemistry

Dergi: Journal of Research in Pharmacy Vol.29 Issue 2, pp.639-666

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001341711

pISSN: 2630-6344

triazole

anticancer

synthesis

activity

molecular modelling

Sayı

Yazarlar:

Merve Camci Eren | Özlen Güzel Akdemir

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 2, pp.639-666

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341711

pISSN:

2630-6344