EXAMINING THE ROLE OF SUPAR AND HS-CRP LEVELS IN PREDICTING CORONARY ARTERY DISEASE SEVERITY IN ACUTE MYOCARDIAL INFARCTION: AN AGE-STRATIFIED ANALYSIS INCORPORATING SYNTAX SCORE

Muhammet Salih Ateş; Abdullah Tunçez; Muhammed Ulvi Yalcin; Kenan Demir; Nazif Aygül; Behlül Bülent Altunkeser; Hüseyin Tezcan; Onur Can Polat; Aslıhan Merve Toprak; Bahadir Ozturk

Makale detayları

EXAMINING THE ROLE OF SUPAR AND HS-CRP LEVELS IN PREDICTING CORONARY ARTERY DISEASE SEVERITY IN ACUTE MYOCARDIAL INFARCTION: AN AGE-STRATIFIED ANALYSIS INCORPORATING SYNTAX SCORE

Yazarlar:

Muhammet Salih Ateş | Abdullah Tunçez | Muhammed Ulvi Yalcin | Kenan Demir | Nazif Aygül | Behlül Bülent Altunkeser | Hüseyin Tezcan | Onur Can Polat | Aslıhan Merve Toprak | Bahadir Ozturk

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Meandros Medical And Dental Journal Vol.25 Issue 4, pp.365-378

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001334508

pISSN:

2149-9063

Anahtar kelimeler:

Özet:

 ABSTRACT Objective: This study examines the association between traditional inflammatory biomarkers, suPAR levels in elderly and young myocardial infarction patients, and coronary artery disease severity. Materials and Methods: In this study, 332 participants, including 227 acute myocardial infarction AMI patients and 107 controls, underwent evaluation through Syntax Score analysis, suPAR, and hs-CRP level assessments. AMI patients were divided into young and elderly groups based on age. Syntax Score was utilized to ascertain the severity of coronary artery disease. Results: suPAR plasma concentrations were significantly higher in AMI patients compared to controls, with values of 2.76 2.32-3.56 in the young MI group and 3.33 2.43-4.41 in the elderly MI group, versus 2.33 1.94-3.11 in the control group p0.001. Additionally, hs-CRP levels were notably elevated in the elderly MI groups p0.001. The ROC analysis identified threshold values for suPAR at 3.10 pgmL and hs-CRP at 6.5 mgdL to predict a Syntax Score of 23 or higher, with suPAR showing 74.7 sensitivity, 69.9 specificity, and an AUC of 0.811 p0.001. The sensitivity of Hs-CRP was 65.8, the specificity was 60.2, and the AUC was 0.700 p0.001. Conclusion: Our study reveals a pivotal relationship between inflammatory markers, particularly suPAR, and Syntax Score in MI patients, suggesting its potential in refining cardiovascular risk assessment and informing future diagnostic and therapeutic approaches for coronary artery disease management.

 ABSTRACT Objective: This study examines the association between traditional inflammatory biomarkers, suPAR levels in elderly and young myocardial infarction patients, and coronary artery disease severity. Materials and Methods: In this study, 332 participants, including 227 acute myocardial infarction AMI patients and 107 controls, underwent evaluation through Syntax Score analysis, suPAR, and hs-CRP level assessments. AMI patients were divided into young and elderly groups based on age. Syntax Score was utilized to ascertain the severity of coronary artery disease. Results: suPAR plasma concentrations were significantly higher in AMI patients compared to controls, with values of 2.76 2.32-3.56 in the young MI group and 3.33 2.43-4.41 in the elderly MI group, versus 2.33 1.94-3.11 in the control group p0.001. Additionally, hs-CRP levels were notably elevated in the elderly MI groups p0.001. The ROC analysis identified threshold values for suPAR at 3.10 pgmL and hs-CRP at 6.5 mgdL to predict a Syntax Score of 23 or higher, with suPAR showing 74.7 sensitivity, 69.9 specificity, and an AUC of 0.811 p0.001. The sensitivity of Hs-CRP was 65.8, the specificity was 60.2, and the AUC was 0.700 p0.001. Conclusion: Our study reveals a pivotal relationship between inflammatory markers, particularly suPAR, and Syntax Score in MI patients, suggesting its potential in refining cardiovascular risk assessment and informing future diagnostic and therapeutic approaches for coronary artery disease management.

 ABSTRACT Objective: This study examines the association between traditional inflammatory biomarkers, suPAR levels in elderly and young myocardial infarction patients, and coronary artery disease severity. Materials and Methods: In this study, 332 participants, including 227 acute myocardial infarction AMI patients and 107 controls, underwent evaluation through Syntax Score analysis, suPAR, and hs-CRP level assessments. AMI patients were divided into young and elderly groups based on age. Syntax Score was utilized to ascertain the severity of coronary artery disease. Results: suPAR plasma concentrations were significantly higher in AMI patients compared to controls, with values of 2.76 2.32-3.56 in the young MI group and 3.33 2.43-4.41 in the elderly MI group, versus 2.33 1.94-3.11 in the control group p0.001. Additionally, hs-CRP levels were notably elevated in the elderly MI groups p0.001. The ROC analysis identified threshold values for suPAR at 3.10 pgmL and hs-CRP at 6.5 mgdL to predict a Syntax Score of 23 or higher, with suPAR showing 74.7 sensitivity, 69.9 specificity, and an AUC of 0.811 p0.001. The sensitivity of Hs-CRP was 65.8, the specificity was 60.2, and the AUC was 0.700 p0.001. Conclusion: Our study reveals a pivotal relationship between inflammatory markers, particularly suPAR, and Syntax Score in MI patients, suggesting its potential in refining cardiovascular risk assessment and informing future diagnostic and therapeutic approaches for coronary artery disease management.

 ÖZET Amaç: Bu çalışma, yaşlı ve genç miyokard enfarktüsü hastalarında geleneksel inflamatuar biyobelirteçler ve suPAR düzeyleri ile koroner arter hastalığı şiddeti arasındaki ilişkiyi incelemektedir. Materyal ve Metot: Çalışmada, 227 miyokard infarktüsü MI hastası ve 107 kontrol grubu olmak üzere toplam 332 katılımcı Syntax Skor analizi, suPAR ve hs-CRP düzeylerinin değerlendirilmesine tabi tutulmuştur. MI hastaları, yaşa göre genç ve yaşlı gruplara ayrılmıştır. Koroner arter hastalığı şiddetinin belirlenmesinde Syntax Skoru kullanılmıştır. Bulgular: SuPAR plazma konsantrasyonları, MI hastalarında kontrol grubuna göre anlamlı derecede daha yüksek bulunmuştur; genç MI grubunda 2.76 2.32-3.56 ve yaşlı MI grubunda 3.33 2.43-4.41 iken, kontrol grubunda 2.33 1.94-3.11 p0.001. Ayrıca, hs-CRP düzeyleri yaşlı MI grubunda belirgin şekilde yüksek bulunmuştur p0.001. ROC analizi, Syntax Skoru 23 veya daha yüksek olan hastaları öngörmek için suPAR için 3.10 pgmL ve hs-CRP için 6.5 mgdL eşik değerlerini belirlemiştir; suPAR, 74.7 duyarlılık, 69.9 özgüllük ve 0.811 AUC ile p0.001 anlamlı bulunmuştur. Hs-CRPnin duyarlılığı 65.8, özgüllüğü 60.2 ve AUCsi 0.700 p0.001 olarak saptanmıştır. Sonuç: Çalışmamız, özellikle suPAR olmak üzere inflamatuar belirteçler ile Syntax Skoru arasındaki önemli ilişkiyi ortaya koymakta ve bu biyomarkerlerin kardiyovasküler risk değerlendirmesini iyileştirme potansiyelini ve koroner arter hastalığı yönetiminde gelecekteki tanısal ve terapötik yaklaşımları bilgilendirme olasılığını önermektedir.

Makale detayları

EXAMINING THE ROLE OF SUPAR AND HS-CRP LEVELS IN PREDICTING CORONARY ARTERY DISEASE SEVERITY IN ACUTE MYOCARDIAL INFARCTION: AN AGE-STRATIFIED ANALYSIS INCORPORATING SYNTAX SCORE

Yazarlar:

Muhammet Salih Ateş | Abdullah Tunçez | Muhammed Ulvi Yalcin | Kenan Demir | Nazif Aygül | Behlül Bülent Altunkeser | Hüseyin Tezcan | Onur Can Polat | Aslıhan Merve Toprak | Bahadir Ozturk

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Meandros Medical And Dental Journal Vol.25 Issue 4, pp.365-378

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001334508

pISSN:

2149-9063

suPAR

Hs-CRP

Young Myocardial Infarction

Elderly Myocardial InfarctionsuPAR

Hs-CRP

Genç Miyokard Enfarktüsü

Yaşlı Miyokard Enfarktüsü

Sayı

Makale detayları

Yazarlar: Muhammet Salih Ateş | Abdullah Tunçez | Muhammed Ulvi Yalcin | Kenan Demir | Nazif Aygül | Behlül Bülent Altunkeser | Hüseyin Tezcan | Onur Can Polat | Aslıhan Merve Toprak | Bahadir Ozturk

Yayıncı: Aydin Adnan Menderes University

Ana Başlıklar: Clinical Sciences (Other)

Dergi: Meandros Medical And Dental Journal Vol.25 Issue 4, pp.365-378

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001334508

pISSN: 2149-9063

Sayı

Yazarlar:

Muhammet Salih Ateş | Abdullah Tunçez | Muhammed Ulvi Yalcin | Kenan Demir | Nazif Aygül | Behlül Bülent Altunkeser | Hüseyin Tezcan | Onur Can Polat | Aslıhan Merve Toprak | Bahadir Ozturk

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Meandros Medical And Dental Journal Vol.25 Issue 4, pp.365-378

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001334508

pISSN:

2149-9063