Changes in cerebral blood flow in rheumatology patients treated with rituximab

Uygar UTKU; Gözde Çetin; Nurhan Atilla

doi:https://doi.org/10.18621/eurj.346321

Makale detayları

Changes in cerebral blood flow in rheumatology patients treated with rituximab

Yazarlar:

Uygar UTKU | Gözde Çetin | Nurhan Atilla

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2018 Vol.4 Issue 4, pp.362-365

Belge Tipi:

Makale

Yayın Tarihi:

10/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000663089

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.346321

Özet:

 


Objective: We
aimed to assess the effects of rituximab therapy on cerebral hemodynamics  in rheumatic patients with transcranial
Doppler (TCD) ultrasonography.  

Methods: The study included seven patients aged 20-65 years
(2 patients with secondary interstitial lung involvement to rheumatoid
arthritis, 3 patients with systemic lupus erythematosus and lupus nephritis, 2
patients with scleroderma and secondary interstitial lung disease) who received
rituximab treatment due to rheumatic diseases. Healthy control group
(non-rheumatic group) consisted of seven age and sex-matched, randomly selected
persons did not have risk factors for atherosclerosis. Bilateral middle
cerebral artery peak-systolic, end-diastolic, and mean blood flow velocities,
Gosling’s pulsatility index values, and Pourcelot’s resistance index values
were recorded with TCD by a neurosonologist before rituximab
administration. Control TCD performed to the rheumatic group after six months
from the last rituximab dosage.  

Results: One patient was
male and six patients were female. Peak-systolic, end-diastolic and mean blood
flow velocities of rheumatic patients were significantly higher than healthy
group (p < 0.001). Peak-systolic,
end-diastolic and mean blood flow velocities of rheumatic patients were
significantly decreased after rituximab therapy (p < 0.001). 

Conclusions: This study
highlights that the increased cerebral blood flow is indirectly
associated with atherosclerosis regarding persistent inflammation in patients
with rheumatic diseases. It was thought that treatment with rituximab could
reverse this situation. 


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Makale detayları

Changes in cerebral blood flow in rheumatology patients treated with rituximab

Yazarlar: Uygar UTKU | Gözde Çetin | Nurhan Atilla

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Sağlık teşvikleri

Dergi: The European Research Journal 2018 Vol.4 Issue 4, pp.362-365

Belge Tipi: Makale

Yayın Tarihi: 10/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000663089

Sıklık: İki Aylık

eISSN: 2149-3189

DOI: https://doi.org/10.18621/eurj.346321

Sayı

Yazarlar:

Uygar UTKU | Gözde Çetin | Nurhan Atilla

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2018 Vol.4 Issue 4, pp.362-365

Belge Tipi:

Makale

Yayın Tarihi:

10/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000663089

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.346321