Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs

Devrim Atilla; Hanife İbişoğlu

Makale detayları

Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs

Yazarlar:

Devrim Atilla | Hanife İbişoğlu

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.22 Issue 4, pp.536-546

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346456

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Six novel bridged structure cyclotriphosphazenes 4a-f were synthesized from the reactions of aryloxycyclotriphosphazenes aryloxy phenoxy 2a and 2-naphthoxy 2b with monocarbonyl curcumin derivatives acetone 3a, cyclopentanone 3b and cyclohexanone 3c for the first time. The structures of the compounds 4a-f were defined by elemental analysis, FT-IR, mass and NMR 1H and 31P spectroscopies. The antimicrobial properties of the compounds 2a, 2b, 3a-c and 4a-f were screened in vitro against Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 6633, Bacillus cereus DSMZ 4312 and Candida albicans ATCC 10231. In addition, effective substance of 3b and 4c were evaluated Minimal Inhibition Concentration.

 Six novel bridged structure cyclotriphosphazenes 4a-f were synthesized from the reactions of aryloxycyclotriphosphazenes aryloxy phenoxy 2a and 2-naphthoxy 2b with monocarbonyl curcumin derivatives acetone 3a, cyclopentanone 3b and cyclohexanone 3c for the first time. The structures of the compounds 4a-f were defined by elemental analysis, FT-IR, mass and NMR 1H and 31P spectroscopies. The antimicrobial properties of the compounds 2a, 2b, 3a-c and 4a-f were screened in vitro against Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 6633, Bacillus cereus DSMZ 4312 and Candida albicans ATCC 10231. In addition, effective substance of 3b and 4c were evaluated Minimal Inhibition Concentration.

 Six novel bridged structure cyclotriphosphazenes 4a-f were synthesized from the reactions of aryloxycyclotriphosphazenes aryloxy phenoxy 2a and 2-naphthoxy 2b with monocarbonyl curcumin derivatives acetone 3a, cyclopentanone 3b and cyclohexanone 3c for the first time. The structures of the compounds 4a-f were defined by elemental analysis, FT-IR, mass and NMR 1H and 31P spectroscopies. The antimicrobial properties of the compounds 2a, 2b, 3a-c and 4a-f were screened in vitro against Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 6633, Bacillus cereus DSMZ 4312 and Candida albicans ATCC 10231. In addition, effective substance of 3b and 4c were evaluated Minimal Inhibition Concentration.

 Six novel bridged structure cyclotriphosphazenes 4a-f were synthesized from the reactions of aryloxycyclotriphosphazenes aryloxy phenoxy 2a and 2-naphthoxy 2b with monocarbonyl curcumin derivatives acetone 3a, cyclopentanone 3b and cyclohexanone 3c for the first time. The structures of the compounds 4a-f were defined by elemental analysis, FT-IR, mass and NMR 1H and 31P spectroscopies. The antimicrobial properties of the compounds 2a, 2b, 3a-c and 4a-f were screened in vitro against Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 6633, Bacillus cereus DSMZ 4312 and Candida albicans ATCC 10231. In addition, effective substance of 3b and 4c were evaluated Minimal Inhibition Concentration.

Makale detayları

Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs

Yazarlar:

Devrim Atilla | Hanife İbişoğlu

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.22 Issue 4, pp.536-546

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346456

pISSN:

2630-6344

Antimicrobial activity

minimal inhibiton concentration

phosphazene

curcumin

Sayı

Makale detayları

Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs

Yazarlar: Devrim Atilla | Hanife İbişoğlu

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Chemistry

Dergi: Journal of Research in Pharmacy Vol.22 Issue 4, pp.536-546

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346456

pISSN: 2630-6344

Antimicrobial activity

minimal inhibiton concentration

phosphazene

curcumin

Sayı

Yazarlar:

Devrim Atilla | Hanife İbişoğlu

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.22 Issue 4, pp.536-546

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346456

pISSN:

2630-6344