Evaluation of biomaterial containing alginate and egg-shell membrane incorporated with β-tricalcium phosphate for treatment of bone defects

Semra Unal

Makale detayları

Evaluation of biomaterial containing alginate and egg-shell membrane incorporated with β-tricalcium phosphate for treatment of bone defects

Yazarlar:

Semra Unal

Yayıncı:

Marmara University

Ana Başlıklar:

Biyomateryaller

Dergi:

International Journal of Advances in Engineering and Pure Sciences Vol.37 Issue 3, pp.293-298

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358176

pISSN:

2636-8277

Anahtar kelimeler:

Özet:

 The freeze-drying procedure was used to create the scaffold that was meant to cure bone deformities. Fourier transform infrared FTIR spectroscopy, X-ray diffraction analysis, swelling and degradation ratio, and scanning electron microscopy SEM tests were used to characterize the scaffolds. Osteoblast cells were used in an in vitro cytotoxicity test to evaluate the scaffolds biocompatibility. The results of the characterization revealed an interconnected porous structure and significant ionic connections between the alginate, egg-shell membrane, and β-tricalcium phosphate β-TCP. The scaffolds are regarded as nontoxic because the cell viability was more than 80. When all the findings are evaluated, β-TCP with alginateegg-shell membrane can be regarded as appropriate for bone treatment applications.

 The freeze-drying procedure was used to create the scaffold that was meant to cure bone deformities. Fourier transform infrared FTIR spectroscopy, X-ray diffraction analysis, swelling and degradation ratio, and scanning electron microscopy SEM tests were used to characterize the scaffolds. Osteoblast cells were used in an in vitro cytotoxicity test to evaluate the scaffolds biocompatibility. The results of the characterization revealed an interconnected porous structure and significant ionic connections between the alginate, egg-shell membrane, and β-tricalcium phosphate β-TCP. The scaffolds are regarded as nontoxic because the cell viability was more than 80. When all the findings are evaluated, β-TCP with alginateegg-shell membrane can be regarded as appropriate for bone treatment applications.

 The freeze-drying procedure was used to create the scaffold that was meant to cure bone deformities. Fourier transform infrared FTIR spectroscopy, X-ray diffraction analysis, swelling and degradation ratio, and scanning electron microscopy SEM tests were used to characterize the scaffolds. Osteoblast cells were used in an in vitro cytotoxicity test to evaluate the scaffolds biocompatibility. The results of the characterization revealed an interconnected porous structure and significant ionic connections between the alginate, egg-shell membrane, and β-tricalcium phosphate β-TCP. The scaffolds are regarded as nontoxic because the cell viability was more than 80. When all the findings are evaluated, β-TCP with alginateegg-shell membrane can be regarded as appropriate for bone treatment applications.

 Kemik defektlerinin tedavisi için tasarlanan iskele, dondurarak kurutma yöntemi kullanılarak üretilmiştir. İskelelerin karakterizasyonu fourier transform infrared FTIR spektroskopisi ve X-ışını kırınım analizi, şişme ve bozunma oranı, taramalı elektron mikroskobu SEM testleri kullanılarak gerçekleştirilmiştir. İskelelerin biyouyumluluğunu analiz etmek için osteoblast hücreleri ile in vitro sitotoksisite deneyi yapılmıştır. Karakterizasyon sonuçları aljinat, yumurta kabuğu membranı ve β-TCP arasında güçlü iyonik etkileşimler ve birbirine bağlı gözenekli yapı olduğunu göstermiştir. Hücre canlılığının 80den fazla olması iskelelerin toksik olmadığını göstermektedir. Tüm sonuçlar birlikte değerlendirildiğinde, aljinatyumurta kabuğu zarı içeren β-TCPnin kemik tedavisi uygulamaları için uygun olduğu düşünülebilir.

Makale detayları

Evaluation of biomaterial containing alginate and egg-shell membrane incorporated with β-tricalcium phosphate for treatment of bone defects

Yazarlar:

Semra Unal

Yayıncı:

Marmara University

Ana Başlıklar:

Biyomateryaller

Dergi:

International Journal of Advances in Engineering and Pure Sciences Vol.37 Issue 3, pp.293-298

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358176

pISSN:

2636-8277

alginate

egg shell membrane

beta-tricalcium phosphate

tissue engineeringaljinat

yumurta kabuğu zarı

beta-trikalsiyum fosfat

doku mühendisliği

Sayı

Makale detayları

Yazarlar: Semra Unal

Yayıncı: Marmara University

Ana Başlıklar: Biyomateryaller

Dergi: International Journal of Advances in Engineering and Pure Sciences Vol.37 Issue 3, pp.293-298

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001358176

pISSN: 2636-8277

Sayı

Yazarlar:

Semra Unal

Yayıncı:

Marmara University

Ana Başlıklar:

Biyomateryaller

Dergi:

International Journal of Advances in Engineering and Pure Sciences Vol.37 Issue 3, pp.293-298

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358176

pISSN:

2636-8277