Determination of sultamicillin in bulk and pharmaceutical preparations via derivatization with NBD-Cl by spectrophotometry

Elif ÖZDEMİR; Duygu TAŞKIN; Sıdıka SUNGUR

Makale detayları

Determination of sultamicillin in bulk and pharmaceutical preparations via derivatization with NBD-Cl by spectrophotometry

Yazarlar:

Elif ÖZDEMİR | Duygu TAŞKIN | Sıdıka SUNGUR

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik | Sağlık teşvikleri

Dergi:

İstanbul Journal of Pharmacy 2020 Vol.50 Issue 1, pp.1-5

Belge Tipi:

Makale

Yayın Tarihi:

3/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000512975

Sıklık:

Aylık

eISSN:

2587-2087

Özet:

 

Background and Aims: A new sensitive and selective method for the determination of sultamicillin in bulk and pharmaceutical preparations has been developed. Methods: The developed method is based on the derivatization of sultamicillin with 4-chloro-7-nitrobenzofurazan in pH 9.0 borate buffer at 70ºC for 60 min. The derivative was measured spectrophotometrically at 432 nm after extraction with chloroform. Results: The method was validated by linearity, LOD, LOQ, accuracy, precision and recovery parameters. The linear range for sultamicillin was 10-50 µg.mL-1 with a correlation coefficient of 0.9999. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 1.47 and 4.41 µg/mL-1, respectively. Conclusion: The suggested method was validated, and can be applied for routine sultamicillin analysis in dosage formsfor industrial analysis.

Makale detayları

Determination of sultamicillin in bulk and pharmaceutical preparations via derivatization with NBD-Cl by spectrophotometry

Yazarlar: Elif ÖZDEMİR | Duygu TAŞKIN | Sıdıka SUNGUR

Yayıncı: Istanbul University

Ana Başlıklar: Farmakoloji ve terapötik | Sağlık teşvikleri

Dergi: İstanbul Journal of Pharmacy 2020 Vol.50 Issue 1, pp.1-5

Belge Tipi: Makale

Yayın Tarihi: 3/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000512975

Sıklık: Aylık

eISSN: 2587-2087

Sayı

Yazarlar:

Elif ÖZDEMİR | Duygu TAŞKIN | Sıdıka SUNGUR

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik | Sağlık teşvikleri

Dergi:

İstanbul Journal of Pharmacy 2020 Vol.50 Issue 1, pp.1-5

Belge Tipi:

Makale

Yayın Tarihi:

3/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000512975

Sıklık:

Aylık

eISSN:

2587-2087