Synthesis and characterizations of novel thiazolyl-thiadiazole derivatives   as telomerase activators

İsmail KAYAĞİL; Ayşe Gül MUTLU; Ülkü BAYHAN; İnanç YILMAZ; Şeref DEMİRAYAK

Makale detayları

Synthesis and characterizations of novel thiazolyl-thiadiazole derivatives as telomerase activators

Yazarlar:

İsmail KAYAĞİL | Ayşe Gül MUTLU | Ülkü BAYHAN | İnanç YILMAZ | Şeref DEMİRAYAK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2018 Vol.42 Issue 3, pp.768-779

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000726110

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Pyridine-3/4-thiocarboxamide derivatives were used as   starting materials for the synthesis of the target compounds. The   pyridine-3/4-thiocarboxamide derivatives were reacted with ethyl   2-chloroacetoacetate in ethanol to give the thiazole derivatives   (1, 2). The two ethyl thiazole-carboxylate derivatives   (1, 2) thus obtained were treated with sodium hydroxide   solution and ethanol and converted to carboxylic acids (3, 4). The carboxylic acid derivatives (3, 4) were reacted   with thiosemicarbazide in phosphoroxy trichloride and aminothiadiazole rings   (5, 6) were formed. Thus, two thiazolyl-thiadiazole amine   derivatives (5, 6) were obtained. These two derivatives   (5, 6) were converted into two chloroacetamidothiadiazole   derivatives (7, 8) by reaction with chloroacetylchloride   over the amino group in the presence of triethylamine in acetone. After all   these steps, the starting materials (7, 8) needed to reach   the target compounds were obtained. With the two derivatives   (7, 8) obtained in this last step, phenol and thiophenol   derivatives were reacted in acetone in the presence of potassium carbonate.   The target compounds, thiazolyl-thiadiazole derivatives   (TDA1−16)1−16)_{\mathbf{1-16}}), are completely unique and their structure   has been elucidated by elemental analysis, IR, NMR, and MS spectral data.   After all these synthesis steps, telomerase activity studies were performed   on the target compounds obtained. For this purpose, a PCR ELISA-based TRAP   method was used on the heart of zebrafish. According to the enzyme assay   results, derivative TDA88_{\mathbf{8}} has shown an   increase of telomerase enzyme activity.

Makale detayları

Synthesis and characterizations of novel thiazolyl-thiadiazole derivatives as telomerase activators

Yazarlar: İsmail KAYAĞİL | Ayşe Gül MUTLU | Ülkü BAYHAN | İnanç YILMAZ | Şeref DEMİRAYAK

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2018 Vol.42 Issue 3, pp.768-779

Belge Tipi: Makale

Yayın Tarihi: 5/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000726110

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

İsmail KAYAĞİL | Ayşe Gül MUTLU | Ülkü BAYHAN | İnanç YILMAZ | Şeref DEMİRAYAK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2018 Vol.42 Issue 3, pp.768-779

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000726110

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527