Relationship between TIM-3 expression and clinicopathological parameters in colorectal carcinomas

Gizem Teoman; Ismail Saygin; Zeynep Türkmen Usta; Zeynep Sağnak Yılmaz

Makale detayları

Relationship between TIM-3 expression and clinicopathological parameters in colorectal carcinomas

Yazarlar:

Gizem Teoman | Ismail Saygin | Zeynep Türkmen Usta | Zeynep Sağnak Yılmaz

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Pathology

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.42 Issue 3, pp.319-323

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359825

pISSN:

1309-4483

Anahtar kelimeler:

Özet:

 Colorectal cancer CRC is a biologically heterogeneous malignancy, complicating prognostic assessments and therapeutic responses. T cell immunoglobulin and mucin-domain containing-3 TIM-3 is an immune checkpoint receptor implicated in immune regulation; however, its prognostic significance in CRC remains unclear. A retrospective analysis was performed on 173 colorectal adenocarcinoma cases. TIM-3 expression in tumor-infiltrating immune cells ICs was assessed using immunohistochemistry. Associations between TIM-3 expression and clinicopathological parameters such as patient age and sex, tumor site and size, grade, invasion status, mismatch repair MMR protein status, and HER2 expression were examined. The impact on overall survival was assessed. High TIM-3 expression was significantly more frequent in females, rectal tumors, high-grade adenocarcinomas, and tumors invading the muscularis propria. In contrast, lower TIM-3 expression correlated with lymphovascular, venous, and perineural invasion. Elevated TIM-3 expression was associated with microsatellite stability MSS and HER2 positivity. High TIM-3 expression predicted reduced overall survival. TIM-3 expression in tumor-infiltrating immune cells may serve as a prognostic biomarker in colorectal carcinoma. Its association with distinct pathological features and survival outcomes highlights its potential role in immune modulation and as a therapeutic target in selected CRC patients.

 Colorectal cancer CRC is a biologically heterogeneous malignancy, complicating prognostic assessments and therapeutic responses. T cell immunoglobulin and mucin-domain containing-3 TIM-3 is an immune checkpoint receptor implicated in immune regulation; however, its prognostic significance in CRC remains unclear. A retrospective analysis was performed on 173 colorectal adenocarcinoma cases. TIM-3 expression in tumor-infiltrating immune cells ICs was assessed using immunohistochemistry. Associations between TIM-3 expression and clinicopathological parameters such as patient age and sex, tumor site and size, grade, invasion status, mismatch repair MMR protein status, and HER2 expression were examined. The impact on overall survival was assessed. High TIM-3 expression was significantly more frequent in females, rectal tumors, high-grade adenocarcinomas, and tumors invading the muscularis propria. In contrast, lower TIM-3 expression correlated with lymphovascular, venous, and perineural invasion. Elevated TIM-3 expression was associated with microsatellite stability MSS and HER2 positivity. High TIM-3 expression predicted reduced overall survival. TIM-3 expression in tumor-infiltrating immune cells may serve as a prognostic biomarker in colorectal carcinoma. Its association with distinct pathological features and survival outcomes highlights its potential role in immune modulation and as a therapeutic target in selected CRC patients.

 Colorectal cancer CRC is a biologically heterogeneous malignancy, complicating prognostic assessments and therapeutic responses. T cell immunoglobulin and mucin-domain containing-3 TIM-3 is an immune checkpoint receptor implicated in immune regulation; however, its prognostic significance in CRC remains unclear. A retrospective analysis was performed on 173 colorectal adenocarcinoma cases. TIM-3 expression in tumor-infiltrating immune cells ICs was assessed using immunohistochemistry. Associations between TIM-3 expression and clinicopathological parameters such as patient age and sex, tumor site and size, grade, invasion status, mismatch repair MMR protein status, and HER2 expression were examined. The impact on overall survival was assessed. High TIM-3 expression was significantly more frequent in females, rectal tumors, high-grade adenocarcinomas, and tumors invading the muscularis propria. In contrast, lower TIM-3 expression correlated with lymphovascular, venous, and perineural invasion. Elevated TIM-3 expression was associated with microsatellite stability MSS and HER2 positivity. High TIM-3 expression predicted reduced overall survival. TIM-3 expression in tumor-infiltrating immune cells may serve as a prognostic biomarker in colorectal carcinoma. Its association with distinct pathological features and survival outcomes highlights its potential role in immune modulation and as a therapeutic target in selected CRC patients.

 Colorectal cancer CRC is a biologically heterogeneous malignancy, complicating prognostic assessments and therapeutic responses. T cell immunoglobulin and mucin-domain containing-3 TIM-3 is an immune checkpoint receptor implicated in immune regulation; however, its prognostic significance in CRC remains unclear. A retrospective analysis was performed on 173 colorectal adenocarcinoma cases. TIM-3 expression in tumor-infiltrating immune cells ICs was assessed using immunohistochemistry. Associations between TIM-3 expression and clinicopathological parameters such as patient age and sex, tumor site and size, grade, invasion status, mismatch repair MMR protein status, and HER2 expression were examined. The impact on overall survival was assessed. High TIM-3 expression was significantly more frequent in females, rectal tumors, high-grade adenocarcinomas, and tumors invading the muscularis propria. In contrast, lower TIM-3 expression correlated with lymphovascular, venous, and perineural invasion. Elevated TIM-3 expression was associated with microsatellite stability MSS and HER2 positivity. High TIM-3 expression predicted reduced overall survival. TIM-3 expression in tumor-infiltrating immune cells may serve as a prognostic biomarker in colorectal carcinoma. Its association with distinct pathological features and survival outcomes highlights its potential role in immune modulation and as a therapeutic target in selected CRC patients.

Makale detayları

Relationship between TIM-3 expression and clinicopathological parameters in colorectal carcinomas

Yazarlar:

Gizem Teoman | Ismail Saygin | Zeynep Türkmen Usta | Zeynep Sağnak Yılmaz

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Pathology

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.42 Issue 3, pp.319-323

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359825

pISSN:

1309-4483

Colorectal Neoplasms

TIM-3

Tumor-Infiltrating Lymphocytes

Immune Checkpoints

Microsatellite Instability

Sayı

Makale detayları

Relationship between TIM-3 expression and clinicopathological parameters in colorectal carcinomas

Yazarlar: Gizem Teoman | Ismail Saygin | Zeynep Türkmen Usta | Zeynep Sağnak Yılmaz

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: Pathology

Dergi: Deneysel ve Klinik Tıp Dergisi Vol.42 Issue 3, pp.319-323

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001359825

pISSN: 1309-4483

Colorectal Neoplasms

TIM-3

Tumor-Infiltrating Lymphocytes

Immune Checkpoints

Microsatellite Instability

Sayı

Yazarlar:

Gizem Teoman | Ismail Saygin | Zeynep Türkmen Usta | Zeynep Sağnak Yılmaz

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Pathology

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.42 Issue 3, pp.319-323

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359825

pISSN:

1309-4483