Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever

Sami Kınıklı; Neziha Yılmaz; Salih Cesur; Ahmet AYDEMİR; Hasan Irmak; Cemal Bulut; Ali Pekcan DEMİRÖZ; Gülay Kınıklı

doi:https://doi.org/10.5799/ahinjs.02.2011.03.0030

Makale detayları

Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever

Yazarlar:

Sami Kınıklı | Neziha Yılmaz | Salih Cesur | Ahmet AYDEMİR | Hasan Irmak | Cemal Bulut | Ali Pekcan DEMİRÖZ | Gülay Kınıklı

Yayıncı:

Sağlık Araştırmaları Derneği

Dergi:

Journal of Microbiology and Infectious Diseases 2011 Vol.1 Issue 03

Belge Tipi:

Makale

Yayın Tarihi:

8/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000488088

Sıklık:

Üç Aylık

eISSN:

2146-9369

pISSN:

2146-3158

DOI:

https://doi.org/10.5799/ahinjs.02.2011.03.0030

Özet:

 

Objectives: Crimean-Congo hemorrhagic fever (CCHF) is a tick borne zoonotic infection. Up till now knowledge about pathogenesis of the disease is limited. Cytokine response is quite important during this infection. The aim of this study was to determine the serum tumor necrosis factor-alpha (TNF-α) and the interleukin-4 (IL-4) levels in patients with CCHF and compare with those of healthy controls.    	Materials and methods: Forty-two adult CCHF patients and 40 healthy subjects were included in this study. The diagnosis of CCHF was based upon anti-CCHF virus IgM positivity (ELISA method), and/or positivity in real time-polymerase chain reaction (RT-PCR) in acute phase serum samples. Serum TNF-α and IL-4 levels were determined by ELISA method.    	Results: In patients with CCHF the mean serum TNF-α level was significantly higher than the control group (15.01 vs. 7.69 pg/ml; p<0.05) and also the mean serum IL-4 levels were significantly higher than the control group (1.07 vs. 0 pg/ml; p<0.05).    	Conclusion: The levels of serum TNF-α and IL-4 in CCHF patients were found higher than healthy controls. These cytokines might play an important role in the pathogenesis of CCHF.

Makale detayları

Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever

Yazarlar: Sami Kınıklı | Neziha Yılmaz | Salih Cesur | Ahmet AYDEMİR | Hasan Irmak | Cemal Bulut | Ali Pekcan DEMİRÖZ | Gülay Kınıklı

Yayıncı: Sağlık Araştırmaları Derneği

Dergi: Journal of Microbiology and Infectious Diseases 2011 Vol.1 Issue 03

Belge Tipi: Makale

Yayın Tarihi: 8/2011

Belge Dili: İngilizce

Document ID (Org No.): 2000488088

Sıklık: Üç Aylık

eISSN: 2146-9369

pISSN: 2146-3158

DOI: https://doi.org/10.5799/ahinjs.02.2011.03.0030

Sayı

Yazarlar:

Sami Kınıklı | Neziha Yılmaz | Salih Cesur | Ahmet AYDEMİR | Hasan Irmak | Cemal Bulut | Ali Pekcan DEMİRÖZ | Gülay Kınıklı

Yayıncı:

Sağlık Araştırmaları Derneği

Dergi:

Journal of Microbiology and Infectious Diseases 2011 Vol.1 Issue 03

Belge Tipi:

Makale

Yayın Tarihi:

8/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000488088

Sıklık:

Üç Aylık

eISSN:

2146-9369

pISSN:

2146-3158

DOI:

https://doi.org/10.5799/ahinjs.02.2011.03.0030