Clinical features and survival outcomes of unclassified high-grade neuroendocrine carcinoma of the lung

Yasemin Söyler; Pınar Akın Kabalak; Suna Kavurgacı; Funda Demirağ; Ülkü Yılmaz

Makale detayları

Clinical features and survival outcomes of unclassified high-grade neuroendocrine carcinoma of the lung

Yazarlar:

Yasemin Söyler | Pınar Akın Kabalak | Suna Kavurgacı | Funda Demirağ | Ülkü Yılmaz

Yayıncı:

Sakarya University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Sakarya Tıp Dergisi Vol.13 Issue 2, pp.295-304

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292767

pISSN:

2146-409X

Anahtar kelimeler:

Özet:

 Background: Differentiating high-grade neuroendocrine carcinomas HGNEC is difficult. We aimed to assess the clinical features and survival outcomes of unclassified HGNEC uHGNEC and to compare it with small-cell lung cancer SCLC. Material and Methods: This was a retrospective and observational study of HGNEC patients. Kaplan-Meier method was used to estimate progression-free survival PFS and overall survival OS. Cox-regression analyses were used to determine the risk factors independently associated with PFS and OS. Results: One hundred twenty-one patients uHGNEC n  35, SCLC n  86 were analysed. The primary tumour was mostly right-sided, located in the centre of the lungs. The IASLC stage at diagnosis was locally advanced in 43 35.5 patients and advanced in 78 64.5 patients. uHGNEC and SCLC groups shared similar clinical features. The study populations median PFS and OS were 8.8 95Cl 7.29  10.30 and 10.9 95Cl 9.9  11.8 months, respectively. uHGNEC- and SCLC groups had a similar PFS 9.4 vs 8.6 months, p  0.99 and OS 12 vs 10.7 months, p  0.51. The six-month, one- and two-year PFS and OS of two groups were also similar. Among all patients, a right-sided tumour HR: 1.558, 95Cl 1.044  2.325, p  0.03 and advanced-stage disease HR: 1.928, 95Cl 1.292  2.877, p  0.001 were prognostic factors for poor OS. Cox-regression analysis indicated that histopathology did not have an impact on PFS and OS. Conclusion: HGNEC patients who cannot be classified pathologically behave like SCLC.

 Background: Differentiating high-grade neuroendocrine carcinomas HGNEC is difficult. We aimed to assess the clinical features and survival outcomes of unclassified HGNEC uHGNEC and to compare it with small-cell lung cancer SCLC. Material and Methods: This was a retrospective and observational study of HGNEC patients. Kaplan-Meier method was used to estimate progression-free survival PFS and overall survival OS. Cox-regression analyses were used to determine the risk factors independently associated with PFS and OS. Results: One hundred twenty-one patients uHGNEC n  35, SCLC n  86 were analysed. The primary tumour was mostly right-sided, located in the centre of the lungs. The IASLC stage at diagnosis was locally advanced in 43 35.5 patients and advanced in 78 64.5 patients. uHGNEC and SCLC groups shared similar clinical features. The study populations median PFS and OS were 8.8 95Cl 7.29  10.30 and 10.9 95Cl 9.9  11.8 months, respectively. uHGNEC- and SCLC groups had a similar PFS 9.4 vs 8.6 months, p  0.99 and OS 12 vs 10.7 months, p  0.51. The six-month, one- and two-year PFS and OS of two groups were also similar. Among all patients, a right-sided tumour HR: 1.558, 95Cl 1.044  2.325, p  0.03 and advanced-stage disease HR: 1.928, 95Cl 1.292  2.877, p  0.001 were prognostic factors for poor OS. Cox-regression analysis indicated that histopathology did not have an impact on PFS and OS. Conclusion: HGNEC patients who cannot be classified pathologically behave like SCLC.

 Background: Differentiating high-grade neuroendocrine carcinomas HGNEC is difficult. We aimed to assess the clinical features and survival outcomes of unclassified HGNEC uHGNEC and to compare it with small-cell lung cancer SCLC. Material and Methods: This was a retrospective and observational study of HGNEC patients. Kaplan-Meier method was used to estimate progression-free survival PFS and overall survival OS. Cox-regression analyses were used to determine the risk factors independently associated with PFS and OS. Results: One hundred twenty-one patients uHGNEC n  35, SCLC n  86 were analysed. The primary tumour was mostly right-sided, located in the centre of the lungs. The IASLC stage at diagnosis was locally advanced in 43 35.5 patients and advanced in 78 64.5 patients. uHGNEC and SCLC groups shared similar clinical features. The study populations median PFS and OS were 8.8 95Cl 7.29  10.30 and 10.9 95Cl 9.9  11.8 months, respectively. uHGNEC- and SCLC groups had a similar PFS 9.4 vs 8.6 months, p  0.99 and OS 12 vs 10.7 months, p  0.51. The six-month, one- and two-year PFS and OS of two groups were also similar. Among all patients, a right-sided tumour HR: 1.558, 95Cl 1.044  2.325, p  0.03 and advanced-stage disease HR: 1.928, 95Cl 1.292  2.877, p  0.001 were prognostic factors for poor OS. Cox-regression analysis indicated that histopathology did not have an impact on PFS and OS. Conclusion: HGNEC patients who cannot be classified pathologically behave like SCLC.

 Amaç: Bu çalışmanın amacı patolojik olarak tiplendirilemeyen yüksek dereceli nöroendokrin karsinomların uYDNEK klinik özelliklerini ve sağ kalım sonuçlarını değerlendirmek ve küçük hücreli akciğer kanseri KHAK ile karşılaştırmaktır. Yöntem ve Gereçler: Bu retrospektif ve gözlemsel çalışmada YDNEK hastalarının klinik özellikleri değerlendirildi. Progresyonsuz sağkalım PFS ve genel sağkalım OS Kaplan-Meier yöntemi kullanılarak hesaplandı. PFS ve OS ile ilişkili bağımsız risk faktörlerini belirlemek için Cox-regresyon analizleri yapıldı. Bulgular: Çalışmaya 121 hasta uYDNEK n35, KHAK n86 dahil edildi. Primer tümör çoğunlukla sağ tarafta ve santral yerleşimliydi. Tanı anındaki evre 43 35,5 hastada lokal ileri, 78 64,5 hastada ileri idi. uYDNEK ve KHAK grupların klinik özellikleri benzerdi. Çalışma popülasyonunun medyan PFS ve OSsi sırasıyla 8,8 95 Cl 7,29  10,30 ve 10,9 95 Cl 9,9  11,8 ay olarak hesaplandı. uYDNEK ve KHAK grupları arasında PFS 9.4 ve 8.6 ay, p  0.99 ve OS 12 ve 10.7 ay, p  0.51 istastistiksel olarak benzer bulundu. 6-aylık, 1-yıllık, 2-yıllık PFS ve OS hesaplandı, 2 grup arasında istatistiksel fark bulunmadı. Cox regresyon analizinde primer tümörün sağ tarafta yerleşimi HR: 1.558, 95Cl 1.044  2.325, p  0.03 ve ileri evre hastalık HR: 1.928, 95Cl 1.292  2.877, p  0.001 OS için kötü prognostik faktör olarak bulundu. Cox regresyon analizinin sonuçları, histopatolojik alt tiplerin PFS ve OS üzerinde bir etkisinin olmadığını gösterdi. Sonuç: Patolojik olarak sınıflandırılamayan YDNEK hastaları KHAK hastaları ile benzer klinik ve sağ kalım özellikleri göstermektedir.

Makale detayları

Clinical features and survival outcomes of unclassified high-grade neuroendocrine carcinoma of the lung

Yazarlar:

Yasemin Söyler | Pınar Akın Kabalak | Suna Kavurgacı | Funda Demirağ | Ülkü Yılmaz

Yayıncı:

Sakarya University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Sakarya Tıp Dergisi Vol.13 Issue 2, pp.295-304

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292767

pISSN:

2146-409X

high-grade neuroendocrine carcinoma

pulmonary neuroendocrine carcinomas

small-cell lung canceryüksek dereceli nöroendokrin karsinoma

küçük hücreli akciğer kanseri

nöroendokrin tümörler

Sayı

Makale detayları

Clinical features and survival outcomes of unclassified high-grade neuroendocrine carcinoma of the lung

Yazarlar: Yasemin Söyler | Pınar Akın Kabalak | Suna Kavurgacı | Funda Demirağ | Ülkü Yılmaz

Yayıncı: Sakarya University

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Sakarya Tıp Dergisi Vol.13 Issue 2, pp.295-304

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001292767

pISSN: 2146-409X

high-grade neuroendocrine carcinoma

pulmonary neuroendocrine carcinomas

small-cell lung canceryüksek dereceli nöroendokrin karsinoma

küçük hücreli akciğer kanseri

nöroendokrin tümörler

Sayı

Yazarlar:

Yasemin Söyler | Pınar Akın Kabalak | Suna Kavurgacı | Funda Demirağ | Ülkü Yılmaz

Yayıncı:

Sakarya University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Sakarya Tıp Dergisi Vol.13 Issue 2, pp.295-304

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292767

pISSN:

2146-409X