EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS

Burcu Sezgin; Murat Soyseven

Makale detayları

EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS

Yazarlar:

Burcu Sezgin | Murat Soyseven

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılıkta Analitik Kimya

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.48 Issue 2, pp.535-543

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001311411

pISSN:

1015-3918

Anahtar kelimeler:

Özet:

 Objective: In our study, it was aimed to make a comparative analysis of the environmental impact profiles of two approaches including Gas Chromatography GC and Liquid Chromatography LC methods, which are frequently used techniques for the determination of non-steroidal anti-inflammatory drugs NSAIDs and their metabolites in environmental water samples. Material and Method: The evaluation of the methods environmental impact was performed using National Environmental Methods Index Label NEMI, Analytical Eco-scale, Analytical GREEnness Metric AGREE, and Green Analytical Procedure Index GAPI. Result and Discussion: The routine analysis of NSAIDs in environmental waters is carried out, resulting in a significant volume of chemical waste. In recent times, there has been a growing significance attributed to environmentally conscious analytical methodologies and the evaluation of methodologies through a green lens to confront this challenge. There is no statistically significant difference in terms of environmental impact profile was observed between the two methods compared.

 Objective: In our study, it was aimed to make a comparative analysis of the environmental impact profiles of two approaches including Gas Chromatography GC and Liquid Chromatography LC methods, which are frequently used techniques for the determination of non-steroidal anti-inflammatory drugs NSAIDs and their metabolites in environmental water samples. Material and Method: The evaluation of the methods environmental impact was performed using National Environmental Methods Index Label NEMI, Analytical Eco-scale, Analytical GREEnness Metric AGREE, and Green Analytical Procedure Index GAPI. Result and Discussion: The routine analysis of NSAIDs in environmental waters is carried out, resulting in a significant volume of chemical waste. In recent times, there has been a growing significance attributed to environmentally conscious analytical methodologies and the evaluation of methodologies through a green lens to confront this challenge. There is no statistically significant difference in terms of environmental impact profile was observed between the two methods compared.

 Objective: In our study, it was aimed to make a comparative analysis of the environmental impact profiles of two approaches including Gas Chromatography GC and Liquid Chromatography LC methods, which are frequently used techniques for the determination of non-steroidal anti-inflammatory drugs NSAIDs and their metabolites in environmental water samples. Material and Method: The evaluation of the methods environmental impact was performed using National Environmental Methods Index Label NEMI, Analytical Eco-scale, Analytical GREEnness Metric AGREE, and Green Analytical Procedure Index GAPI. Result and Discussion: The routine analysis of NSAIDs in environmental waters is carried out, resulting in a significant volume of chemical waste. In recent times, there has been a growing significance attributed to environmentally conscious analytical methodologies and the evaluation of methodologies through a green lens to confront this challenge. There is no statistically significant difference in terms of environmental impact profile was observed between the two methods compared.

 Amaç: Çalışmamızda, çevresel su örneklerinde steroid olmayan antiinflamatuar ilaçların NSAİİ ve bunların metabolitlerinin tayininde sıklıkla kullanılan teknikler olan Gaz Kromatografisi GK ve Sıvı Kromatografisi SK yöntemlerini içeren iki yaklaşımın çevresel etki profillerinin karşılaştırmalı bir analizinin yapılması amaçlanmıştır. Gereç ve Yöntem: Yöntemlerin çevresel etkisinin değerlendirilmesi, Ulusal Çevresel Yöntemler İndeks Etiketi NEMI, Analitik Eko-ölçek, Analitik Yeşillik Metriği AGREE ve Yeşil Analitik Prosedür İndeksi GAPI kullanılarak gerçekleştirilmiştir. Sonuç ve Tartışma: Çevresel sularda NSAİİlerin rutin analizi gerçekleştirilmekte ve bunun sonucunda önemli miktarda kimyasal atık ortaya çıkmaktadır. Son zamanlarda, çevreye duyarlı analitik metodolojilere ve bu zorluğun üstesinden gelmek için metodolojilerin yeşil bir mercekle değerlendirilmesine atfedilen önem giderek artmaktadır. Karşılaştırılan iki yöntem arasında çevresel etki profili açısından istatistiksel olarak anlamlı bir fark olmadığı gözlenmiştir.

Makale detayları

EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS

Yazarlar:

Burcu Sezgin | Murat Soyseven

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılıkta Analitik Kimya

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.48 Issue 2, pp.535-543

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001311411

pISSN:

1015-3918

Environmental waters

green chemistry

greenness assessment

nonsteroidal anti-inflammatory drugs (NSAIDs)Çevresel sular

nonsteroid anti-inflamatuvar ilaçlar (NSAİİ)

yeşil kimya

yeşillik değerlendirmesi

Sayı

Makale detayları

Yazarlar: Burcu Sezgin | Murat Soyseven

Yayıncı: Ankara University

Ana Başlıklar: Eczacılıkta Analitik Kimya

Dergi: Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.48 Issue 2, pp.535-543

Belge Tipi: Makale

Yayın Tarihi: 5/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001311411

pISSN: 1015-3918

Sayı

Yazarlar:

Burcu Sezgin | Murat Soyseven

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılıkta Analitik Kimya

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.48 Issue 2, pp.535-543

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001311411

pISSN:

1015-3918