Evaluation of the Diagnostic Performance of the Indirect Hemagglutination Test in the Differential Diagnosis of Cystic Echinococcosis: Single Center Experience

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Makale detayları

Evaluation of the Diagnostic Performance of the Indirect Hemagglutination Test in the Differential Diagnosis of Cystic Echinococcosis: Single Center Experience

Yazarlar:

N.A.

Yayıncı:

Ankara University

Ana Başlıklar:

Medical Parasitology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 1, pp.69-75

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349814

pISSN:

0365-8104

Anahtar kelimeler:

Özet:

 Objectives: The purpose of this study is to reveal the epidemiological data of cystic echinococcosis CE patients who applied to our hospital and to determine the diagnostic performance of the indirect hemagglutination test IHAT. Materials and Methods: The patients whose serum samples were routinely sent to Ankara University İbni Sina Research and Application Hospital, Central Laboratory for CE IHAT between 01.01.2023 and 01.09.2024 were evaluated. The patients IHAT results were interpreted with clinical and laboratory findings and radiological imaging results. In the evaluation of the IHAT, the serological titer, which is 1320 and above, is declared positive, and 180 and 1160 are declared as suspicious. Results: Serology results of 636 patients were evaluated. The positivity rate was found to be 5.97. The age group of 0-19 had the greatest positivity percentage 19. Age-group differences in CE seropositivity were statistically significant p0.011. The patient group with cystic lesions apparent in radiological imaging had the greatest seropositivity rate 11.9. The seropositivity rate of IHAT in patients with CE-specific findings identified on radiological imaging was calculated as 39.6 when the threshold value was taken as 180. The seronegativity rate was found to be 95.7 in patients with no cysts detected on radiological imaging . Conclusion: The positivity rate of IHAT was found to be low in patients with CE lesions identified on radiological imaging. Therefore, it is thought that it would be beneficial to utilize a second serological test together with IHAT to increase analytical sensitivity in routine laboratory tests. Keywords: Cystic echinococcosis, indirect hemagglutination test, seropositivity rates, radiological imaging.

 Objectives: The purpose of this study is to reveal the epidemiological data of cystic echinococcosis CE patients who applied to our hospital and to determine the diagnostic performance of the indirect hemagglutination test IHAT. Materials and Methods: The patients whose serum samples were routinely sent to Ankara University İbni Sina Research and Application Hospital, Central Laboratory for CE IHAT between 01.01.2023 and 01.09.2024 were evaluated. The patients IHAT results were interpreted with clinical and laboratory findings and radiological imaging results. In the evaluation of the IHAT, the serological titer, which is 1320 and above, is declared positive, and 180 and 1160 are declared as suspicious. Results: Serology results of 636 patients were evaluated. The positivity rate was found to be 5.97. The age group of 0-19 had the greatest positivity percentage 19. Age-group differences in CE seropositivity were statistically significant p0.011. The patient group with cystic lesions apparent in radiological imaging had the greatest seropositivity rate 11.9. The seropositivity rate of IHAT in patients with CE-specific findings identified on radiological imaging was calculated as 39.6 when the threshold value was taken as 180. The seronegativity rate was found to be 95.7 in patients with no cysts detected on radiological imaging . Conclusion: The positivity rate of IHAT was found to be low in patients with CE lesions identified on radiological imaging. Therefore, it is thought that it would be beneficial to utilize a second serological test together with IHAT to increase analytical sensitivity in routine laboratory tests. Keywords: Cystic echinococcosis, indirect hemagglutination test, seropositivity rates, radiological imaging.

 Objectives: The purpose of this study is to reveal the epidemiological data of cystic echinococcosis CE patients who applied to our hospital and to determine the diagnostic performance of the indirect hemagglutination test IHAT. Materials and Methods: The patients whose serum samples were routinely sent to Ankara University İbni Sina Research and Application Hospital, Central Laboratory for CE IHAT between 01.01.2023 and 01.09.2024 were evaluated. The patients IHAT results were interpreted with clinical and laboratory findings and radiological imaging results. In the evaluation of the IHAT, the serological titer, which is 1320 and above, is declared positive, and 180 and 1160 are declared as suspicious. Results: Serology results of 636 patients were evaluated. The positivity rate was found to be 5.97. The age group of 0-19 had the greatest positivity percentage 19. Age-group differences in CE seropositivity were statistically significant p0.011. The patient group with cystic lesions apparent in radiological imaging had the greatest seropositivity rate 11.9. The seropositivity rate of IHAT in patients with CE-specific findings identified on radiological imaging was calculated as 39.6 when the threshold value was taken as 180. The seronegativity rate was found to be 95.7 in patients with no cysts detected on radiological imaging . Conclusion: The positivity rate of IHAT was found to be low in patients with CE lesions identified on radiological imaging. Therefore, it is thought that it would be beneficial to utilize a second serological test together with IHAT to increase analytical sensitivity in routine laboratory tests. Keywords: Cystic echinococcosis, indirect hemagglutination test, seropositivity rates, radiological imaging.

 Amaç: Çalışmamızın amacı hastanemize başvuran hastaların kistik ekinokokkoz KE epidemiyolojik verilerini ortaya koymak ve indirekt hemaglütinasyon testinin IHAT tanısal performansını değerlendirmektir. Gereç ve Yöntem: Çalışma kapsamında 01.01.2023 ile 01.09.2024 tarihleri arasında KE IHAT istemi ile Ankara Üniversitesi İbni Sina Araştırma ve Uygulama Hastanesi Merkez Laboratuvarına rutin olarak serum örnekleri gönderilen hastalar değerlendirildi. Hastaların IHAT sonuçları, klinik ve laboratuvar bulguları ve radyolojik görüntüleme sonuçlarıyla birlikte değerlendirildi. Antikor titresi 1320 ve üzerindeki değerler pozitif, 180 ve 1160 ise şüpheli olarak belirtildi. Bulgular: Altı yüz otuz altı hastanın seroloji sonuçları değerlendirildi. Pozitiflik oranı 5,97 olarak belirlendi. 0-19 yaş grubu en yüksek pozitiflik yüzdesine 19 sahipti. Yaş gruplarının seropozitiflik oranları istatistiksel olarak anlamlı derecede farklı bulundu p0,011. Radyolojik görüntülemede kistik lezyonları görülen hasta grubu en yüksek seropozitiflik oranına 11,9 sahipti. Radyolojik görüntülemelerde KE açısından spesifik bulguları olan hastalarda IHATın seropozitiflik oranı eşik değer 180 olarak alındığında 39,6 olarak hesaplandı. Radyolojik görüntülemelerde kist saptanmayan hastalarda ise seronegatiflik oranı 95,7 olarak tespit edildi. Sonuç: Radyolojik görüntülemelerde KE lezyonları tanımlanan hastalarda IHATın pozitiflik oranı düşük bulunmuştur. Bu nedenle rutin laboratuvar testlerinde analitik duyarlılığı artırmak için IHAT ile birlikte ikinci bir serolojik testin kullanılmasının faydalı olacağı düşünülmektedir. Anahtar Kelimeler: Kistik ekinokokkoz, indirekt hemaglütinasyon testi, seropozitiflik oranları, radyolojik görüntüleme.

Makale detayları

Evaluation of the Diagnostic Performance of the Indirect Hemagglutination Test in the Differential Diagnosis of Cystic Echinococcosis: Single Center Experience

Yazarlar:

N.A.

Yayıncı:

Ankara University

Ana Başlıklar:

Medical Parasitology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 1, pp.69-75

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349814

pISSN:

0365-8104

Cystic echinococcosis

indirect hemagglutination test

seropositivity rates

radiological imagingKistik ekinokokkoz

indirekt hemaglütinasyon testi

seropozitiflik oranları

radyolojik görüntüleme

Sayı

Makale detayları

Yazarlar: N.A.

Yayıncı: Ankara University

Ana Başlıklar: Medical Parasitology

Dergi: Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 1, pp.69-75

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001349814

pISSN: 0365-8104

Sayı

Yazarlar:

N.A.

Yayıncı:

Ankara University

Ana Başlıklar:

Medical Parasitology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 1, pp.69-75

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349814

pISSN:

0365-8104